Morphometric evaluation of cerebellar structures in late monocular blindness

Özen, Özkan; Aslan, Fatih

doi:10.1007/s10792-020-01629-5

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Cerebellar volumes of patients suffering from nervous system diseases (major depression, dementia, bipolar disorder, schizophrenia, monocular blindness, chronic tinnitus) were measured with different methods. [6,11,[19][20][21][22] In some of these studies, VolBrain and similar volumetric methods were used, which provide automatic and accurate segmentation of the cerebellum on standard resolution T1-weighted brain MR images. [6,[20][21][22][23] The neurobiological processes that lead to depression have not been fully understood in extensive preclinical and clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…[6,11,[19][20][21][22] In some of these studies, VolBrain and similar volumetric methods were used, which provide automatic and accurate segmentation of the cerebellum on standard resolution T1-weighted brain MR images. [6,[20][21][22][23] The neurobiological processes that lead to depression have not been fully understood in extensive preclinical and clinical studies. Current studies have related depression with a reduction in the number and/or size of glia and neurons in different brain regions.…”

Section: Discussionmentioning

confidence: 99%

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Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method

Özmen¹,

Saygın²,

Uysal³

et al. 2021

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Objectives: Besides the well-known sensorimotor control function, the cerebellum is also associated with cognitive functions and mood via the cerebral-cerebellar circuit. This study aimed to investigate possible cerebellar morphometric changes in untreated patients with depression. Methods: Brain magnetic resonance (MR) images of 40 adults (age: 18–50 years), including 20 untreated depression patients and 20 healthy controls were analysed prospectively. Intracranial cavity and total cerebellar volumes were measured by using VolBrain. The cerebellum segmentation was performed with CERES to obtain the total gray matter volumes and cortical thickness of the lobules. Results: Total cerebellar volume was 141.27±13.12 cm3 in the depressed group and 142.63±8.01 cm3 in the control group (p>0.05). The difference between males and females in the depressed group was not statistically significant (p>0.05). Total cerebellar volume was approximately 11% of total intracranial volume in both groups. The cortical thickness of lobule V (right-total), lobule VIIIB (right), and lobule IX (right) was smaller in the depressed group, independent of sex (p<0.05). Lobule V, VIIIB and IX volume was smaller and Crus-I cortical thickness was increased in depressed females (p<0.05). Conclusion: The cerebellar volume and cortical thickness of cerebellar lobules in patients with depression show significant differences compared to healthy subjects.

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