Morphometry in the cytologic evaluation of thyroid follicular lesions

Nagashima, Takeshi; Suzuki, Masato; Oshida, Masaki; Hashimoto, Hideyuki; Yagata, Hiroshi; Shishikura, Tomotane; Koda, Keiji; Nakajima, Nobuyuki

doi:10.1002/(sici)1097-0142(19980425)84:2<115::aid-cncr8>3.0.co;2-o

Cited by 44 publications

(35 citation statements)

References 6 publications

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“…Using nuclear morphometry, we can quantify a number of parameters such as those related to nuclear size and shape. [8] It has been suggested that nuclear morphometric parameters such as nuclear area and perimeter,[910] nuclear area coefficient of variation,[11] and shape factors[11] may allow differentiation between thyroid lesions. Application of morphometry to cytology would be useful for the purpose of automated screening as well as accurate diagnosis of thyroid tumors.…”

Section: Introductionmentioning

confidence: 99%

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Khatri

Choudhury

Thomas

2017

J Cytol

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Context:Thyroid nodules represent a common problem, with an estimated prevalence of 4–7%. Although fine needle aspiration cytology (FNAC) has been accepted as a first line diagnostic test, the rate of false negative reports of malignancy is still high. Nuclear morphometry is the measurement of nuclear parameters by image analysis. Image analysis can merge the advantages of morphologic interpretation with those of quantitative data.Aims:To evaluate the nuclear morphometric parameters in fine needle aspirates of thyroid lesions and to study its role in differentiating benign from malignant thyroid lesions.Material and Methods:The study included 19 benign and 16 malignant thyroid lesions. Image analysis was performed on Giemsa-stained FNAC slides by Nikon NIS-Elements Advanced Research software (Version 4.00). Nuclear morphometric parameters analyzed included nuclear size, shape, texture, and density parameters.Statistical Analysis:Normally distributed continuous variables were compared using the unpaired t-test for two groups and analysis of variance was used for three or more groups. Tukey or Tamhane's T2 multiple comparison test was used to assess the differences between the individual groups. Categorical variables were analyzed using the chi square test.Results and Conclusion:Five out of the six nuclear size parameters as well as all the texture and density parameters studied were significant in distinguishing between benign and malignant thyroid lesions (P < 0.05). Cut-off values were derived to differentiate between benign and malignant cases.

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Section: Introductionmentioning

confidence: 99%

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Khatri

Choudhury

Thomas

2017

J Cytol

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“…The NA and SD of each specimen were aggregated. The coefficient of variation of the nuclear area (NACV) was calculated as the objective parameter of anisonucleosis by the following formula: NACV (%) = (SD of NA)/(mean NA) x 100 [13]. …”

Section: Methodsmentioning

confidence: 99%

Prevention of Cutaneous Tissue Contracture During Removal of Craniofacial Implant Superstructures for CT and MRI Studies

Uehara¹,

Ikeda²,

Nonaka³

et al. 2010

JOMR

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ObjectivesThe purpose of this study is to analyze the morphological change of cell nuclei and the change of proliferating activity of oral malignancy and epithelial dysplasia between before and after photodynamic therapy in order to predict recurrence.Material and methodsWe experienced 14 cases of oral squamous cell carcinoma, one case of verrucous carcinoma and seven cases of epithelial dysplasia treated by photodynamic therapy (PDT). The mean nuclear area (NA) and coefficient of variation of the nuclear area (NACV) of 100 nuclei per slide were calculated using computer-assisted image analysis in hematoxylin and eosin stained biopsy specimens before and after PDT. Additionally, proliferating cell nuclear antigen (PCNA) immunohistochemistry was carried out in each specimen.ResultsThe mean NA after PDT was significantly lower than that before PDT in the nonrecurrent group. However, there was no significant difference in mean NA before and after PDT in the recurrent group. There were no significance differences in NACV before and after PDT in either the nonrecurrent or recurrent group. Furthermore, the PCNA labelling indices of the specimens after PDT was significantly lower than that before PDT in both the nonrecurrent and the recurrent group.ConclusionsMean nuclear area in the biopsy specimen after photodynamic therapy is likely to be a predictive marker for the recurrence of oral squamous cell carcinoma or epithelial dysplasia subjected to photodynamic therapy, while coefficient of variation of the nuclear area and proliferating cell nuclear antigen labelling indices are less helpful in predicting the recurrence of such lesions.

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“…Međutim, dalja istraživanja na ovom polju dala su kontradiktorne rezultate [14][15][16] . Kada su u pitanju PTC, većina autora se slaže da povećanje površine jedara tireocita ukazuje na malignu transformaciju ćelija 17,18 . Međutim, problem folikularnih neoplazmi i dalje je nerešen 19,20 .…”

Section: Uvodunclassified

“…U analizi bolesnika sa citološkom interpretacijom suspektno maligno, Nagashima i sar. 17,18 ne nalaze povezanost analizirane površine jedara i perimetra jedara sa određenim histopatološkim podtipovima folikularnih lezija. Izražena varijacija u površini jedara tireocita ogleda se u značajnim razlikama KVPJ tireocita između FTC i benignih lezija.…”

Section: Diskusijaunclassified

Thyrocyte morphomethric analysis significance in differential diagnosis of thyroid carcinoma

Janković

Andjelkovic

Cerović³

et al. 2011

VOJNOSANIT PREGL

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Morphometry in the cytologic evaluation of thyroid follicular lesions

Abstract: Preoperative quantitative estimations of cytologic nuclear features are useful for the preoperative differential diagnosis of follicular lesions of the thyroid.

Cited by 44 publications

References 6 publications

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Role of morphometry in the cytological differentiation of benign and malignant thyroid lesions

Prevention of Cutaneous Tissue Contracture During Removal of Craniofacial Implant Superstructures for CT and MRI Studies

Thyrocyte morphomethric analysis significance in differential diagnosis of thyroid carcinoma

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