Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway

Zhou, Lijuan; Wang, Han; Jing, Jing; Yu, Lijuan; Wu, Xianjie; Zhang, Lu

doi:10.1038/s41598-018-32138-2

Cited by 39 publications

(35 citation statements)

References 41 publications

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“…The results showed that the expression of β-catenin and p-Erk 1/2 in the DP spheroid groups was up-regulated, and that of SFRP2 was down-regulated in comparison to the control and minoxidil groups. The WNT/β-catenin pathway has a critical role in regulating the hair cycle by promoting hair growth ( 35 ). β-Catenin is a key regulator of hair follicle growth, and it is reported to be the primary initiator of the anagen phase ( 36 ).…”

Section: Resultsmentioning

confidence: 99%

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

et al. 2020

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The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes up-regulated β-catenin, promoting the development of hair follicles.

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Section: Resultsmentioning

confidence: 99%

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

et al. 2020

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“…To understand the hair-inducing property of hFB-EVs, we also treated ORS cells with hFB-EVs. Migration and proliferation of ORS cells contributed to the outgrowth of ORS cells and HF [39,40]. ORS cells have been involved in the migration of hair stem cells to hair bulb for facilitating HF elongation [41].…”

Section: Discussionmentioning

confidence: 99%

Human fibroblast‐derived extracellular vesicles promote hair growth in cultured human hair follicles

et al. 2021

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Hair loss is a prevalent medical condition affecting both genders. In this study, we investigate the effects of a specific class of extracellular vesicles (EVs), namely human normal fibroblast‐derived EVs (hFB‐EVs), on human dermal papilla (DP) and outer root sheath (ORS) cells and examine the molecular mechanisms responsible for hair growth in hair follicles (HFs). We find that Wnt3a, which maintains the hair‐generating activity of DP cells, is enriched and more strongly associated with hFB‐EVs than with fibroblasts. Furthermore, hFB‐EV‐associated Wnt3a mediated receptor activation in cultured DP cells, leading to an increase in β‐catenin in the cytoplasm and its translocation into the nucleus, thereby elevating expression of the target genes Axin2 and Lef1. Additionally, hFB‐EVs promoted the migration, proliferation, and differentiation of ORS cells and elongation of the hair shaft in human HFs. These findings revealed a novel mechanism by which hFB‐EVs influence hair growth.

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“…Injection of morroniside (100 µM) in depilated mouse skin increased the skin thickness and immunohistochemical analysis revealed the elevated expression of β-catenin in epidermis, outer root sheath cells, and matrix during telogen–anagen transition. The compound markedly reduced catagen entry as compared to control [ 72 ]. Several other plant extracts, such as extracts of polygonum multiflorum [ 73 ], Aconitie ciliare tuber [ 75 ], Thuja orientalis [ 76 ], Malva verticilata [ 77 ], and rice bran extract [ 79 ], have been reported to promote mouse skin hair growth or the proliferation of human DPCs via the activation of β-catenin signaling.…”

Section: Progress In Developing Therapy For Hair Loss By Targetingmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

140

105

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Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

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Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway

Cited by 39 publications

References 41 publications

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

Human fibroblast‐derived extracellular vesicles promote hair growth in cultured human hair follicles

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

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