Mortalité et causes de décès dans la schizophrénie : étude prospective entre dix et 14 ans d’une cohorte de 150 sujets

Loas, Gwenolé; Azi, Amine; Noisette, C.; Yon, Valérie

doi:10.1016/j.encep.2007.07.005

Cited by 25 publications

(6 citation statements)

References 21 publications

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“…Unfortunately, the heterogeneity of the designs of these other studies preclude direct comparison. Furthermore, most of the studies mentioned here looked at drug prescriptions throughout the study period although, like us, Joukemaa et al (13) and Loas et al (31) measured drug prescriptions at baseline.…”

Section: Discussionmentioning

confidence: 94%

“…More specifically, we also found no association between DDDs and mortality. Other studies have found that higher prescribed doses of antipsychotics are linked to a higher mortality rate (31) and to an increased risk of mortality from coronary heart disease and stroke (61).…”

Section: Discussionmentioning

confidence: 99%

“…Finally, there is a relative paucity of studies evaluating the link between symptom severity (in the mental disorder) and other baseline measures like psychotropic side effects and premature death. To our knowledge, only one study has found an association between disease characteristics like symptom severity and mortality (31), and only one study took place in the Netherlands. In this study we aim to contribute to the knowledge of risk factors and correlates of excess mortality in SMI patients.…”

Section: Introductionmentioning

confidence: 99%

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Dying Too Soon: Excess Mortality in Severe Mental Illness

et al. 2019

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Aims:We aimed to identify baseline predictors of mortality in patients with a severe mental illness (SMI) over a 6-year period and to describe mortality rates as standardised mortality ratios (SMRs). We hypothesised that cardiovascular diseases, older age, cigarette smoking, more severe psychiatric symptoms and more severe psychotropic side effects, and alcohol or drug use were independent risk factors for mortality.Method: Medical examinations were conducted at baseline in a cohort of 322 SMI patients. SMRs were estimated after 6 years and an evaluation was made of the impact of a wide range of variables on survival time.Results: Almost 11% of the SMI patients had died at the end of the study period. Allcause SMRs were 4.51 (95% CI 3.07-5.95) for all SMI patients (4.89, 95% CI 2.97-6.80 for men, and 3.94, 95% CI 1.78-6.10 for women). Natural causes accounted for 86% of excess mortality and unnatural causes for 14%. Cardiovascular disease was a major contributor to this excess mortality. Multivariate Cox regression analyses showed that premature death was associated with a longer history of tobacco use (HR: 1.03, 95% CI 1.02-1.03) and more severe symptoms of disorganisation (HR: 2.36, 95% CI 2.21-2.52). Conclusions:The high SMR and the incidence of cardiovascular disease-related death in SMI patients in our study justify concern. This study underscores the urgent need for interventions to reduce excess mortality in patients with SMI.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dying Too Soon: Excess Mortality in Severe Mental Illness

et al. 2019

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“…Les patients souffrant de schizophrénie ont un taux de mortalité 3 à 4 fois supérieur et une espérance de vie diminuée par rapport à la population générale [1][2][3][4][5][6][7]. Cet excès de mortalité est lié en partie aux suicides et décès d'origine accidentelle [2,8], mais s'explique également par la fréquence élevée des co-morbidités cardiovasculaires et métaboliques [1,3,5,[9][10][11].…”

Section: Introductionunclassified

Niveau de vigilance des psychiatres pour les facteurs de risque cardiovasculaire chez les patients schizophrènes

et al. 2015

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“…La conducta suicida se debe a la presencia de trastornos mentales, de los cuales los más frecuentes son tanto el trastorno depresivo mayor y la esquizofrenia (Aliaga, Rodríguez, Ponce, Frisancho y Vereau, 2006;Balhara y Verma, 2012), como otras variables de apoyo social, nivel de estudio y otros parámetros socioeconómicos (Bani-Fatemi et al, 2013;Cañón et al, 2011;Carvajal y Caro, 2011;Labonté et al, 2013;Labonté et al, 2012;oms, 2012;Pavez, Santander, Carranza y Vera, 2009), y se estima que es la principal causa de muerte en pacientes con trastornos mentales en comparación con sujetos sanos de la población general (Capasso, Lineberry, Bostwick, Decker y St Sauveur, 2008;Carlborg, Jokinen, Jonsson, Nordstrom y Nordstrom, 2008;Gómez-Durán, Martin-Fumadó y Hurtado-Ruiz, 2012;Haukka, Suominen, Partonen y Lonnqvist, 2008;Li, Suominen, Partonen y Lonnqvist, 2008;Loas, Azi, Noisette y Yon, 2008;McGirr y Turecki, 2008;Osborn, Levy, Nazareth y King, 2008;Ran et al, 2008;Silverton, Mednick, Holst y John, 2008;Thong, Su, Chan y Chia, 2008;Tidemalm, Langström, Lichtenstein y Runeson, 2008;Zisook et al, 2010), aunque otros estudios reportan que los fallecimientos en población psiquiátrica se relacionan con el padecimiento de enfermedades físicas. Aun así, los resultados de dichos estudios son controvertidos (Tidemalm,Langström, Los autores declaran que no existe conflicto de intereses.…”

Section: Introductionunclassified

Riesgo suicida y desesperanza en pacientes psiquiátricos hospitalizados

et al. 2014

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La desesperanza (D) incrementa el riesgo suicida (RS). No se conoce esta información en una muestra representativa de pacientes psiquiátricos hospitalizados en Santa Marta (Colombia). El presente estudio buscó describir la prevalencia y hallar la asociación entre el RS y la D, de acuerdo con variables sociodemográficas y clínicas, en pacientes con trastornos psiquiátricos. Se realizó un estudio transversal, descriptivo correlacional. Se evaluaron 61 pacientes con la Escala de Riesgo Suicida de Plutchik, la Escala de Desesperanza de Beck y un cuestionario de datos sociodemográficos. Como principal resultados, se resalta que el 60,7% de la muestra presentó RS y el 70,4% D. Se encontró una correlación significativa entre el RS y la D, también entre el RS y los intentos previos de suicidio. No se hallaron correlaciones entre el RS, la D y variables sociodemográficas y clínicas. En conclusión, a mayor nivel de D, mayor RS en la población psiquiátrica estudiada.

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Mortalité et causes de décès dans la schizophrénie : étude prospective entre dix et 14 ans d’une cohorte de 150 sujets

Cited by 25 publications

References 21 publications

Dying Too Soon: Excess Mortality in Severe Mental Illness

Dying Too Soon: Excess Mortality in Severe Mental Illness

Niveau de vigilance des psychiatres pour les facteurs de risque cardiovasculaire chez les patients schizophrènes

Riesgo suicida y desesperanza en pacientes psiquiátricos hospitalizados

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