Mortality and cancer incidence following radiotherapy for seminoma of the testis

Horwich, A.; Bell, Jan

doi:10.1016/0167-8140(94)90457-x

Cited by 51 publications

(16 citation statements)

References 24 publications

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“…Our findings also show that gastro-duodenal ulcer, recognised as radiotherapy-induced longterm toxicity (Fosså et al, 1989), not only represents a significant morbidity but may also be the patient's cause of death. This observation is in contrast to Horwich and Bell's (1994) report, who did not find an excess of the death rate of benign disorders after radiotherapy for seminoma. The high SMR due to disorders of the liver or its excretory duct system was surprising and requires a future in-depth analysis.…”

Section: Discussioncontrasting

confidence: 99%

Increased mortality rates in young and middle-aged patients with malignant germ cell tumours

et al. 2004

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Section: Discussioncontrasting

confidence: 99%

Increased mortality rates in young and middle-aged patients with malignant germ cell tumours

et al. 2004

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“…It is too early to estimate the possible risk of secondary malignancies. However, esophageal cancer in 1 patient outside the radiation field and acute myeloid leukemia in a 73-year-old patient can be ruled out as secondary malignancies following radiotherapy due to the short interval between irradiation and the second tumor (Horwich and Bell, 1994). Two patients exhibited either a contralateral testicular cancer or TIN.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for stages I and IIA/B testicular seminoma

Bamberg

Schmidberger

Meisner³

et al. 1999

Int. J. Cancer

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“…This high cure rate heightens concern over the risk of late treatment effects including second primary cancers (Fossa, 2004;Zagars et al, 2004), of which an increased incidence has been found following both radiotherapy and chemotherapy (Travis et al, 2005). This risk may depend upon specific details of treatment such as the chemotherapeutic drugs used or choice of radiation dose and field; a previous study from the Thames Cancer Registry (TCR) based on 859 patients treated with radiotherapy for seminoma between 1961 and 1985 did not find an increase in mortality risks from other causes (Horwich and Bell, 1994). In this report we extend the previous TCR study, assessing the overall mortality and incidence of second primary cancers in 9892 patients with first testis cancer diagnosis between 1960 and 2004.…”

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Mortality and incidence of second cancers following treatment for testicular cancer

2007

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We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960 -1969 to 99% in 1990 -2004 for seminomas, and from 55 to 95% for nonseminomas. In the early period mortality was still significantly increased more than 15 years after diagnosis in both groups, whereas in more recent periods the excess deaths mainly occurred in the first 5 years after diagnosis. For seminomas, there was a significant excess of cancers of the colon (standardised incidence ratio (SIR) 2.36; 95% confidence interval (CI) 1.13 -4.35), soft tissue (SIR 13.64; CI 1.65 -49.28) and bladder (SIR 4.28; CI 2.28 -7.31) in the long term (20 þ years after diagnosis), of pancreatic cancer in both the medium (10 -19 years) (SIR 2.91; CI 1.26 -5.73) and long term (SIR 5.48; CI 2.37 -10.80), of leukaemia in both the short (0 -9 years) (SIR 3.01; CI 1.44 -5.54) and long term (SIR 4.48; CI 1.64 -9.75), and of testis cancer in both the short (SIR 6.69;) and medium term (SIR 3.96; CI 1.08 -10.14). For nonseminomas, significant excesses were found in the long term for cancers of the stomach (SIR 5.13; CI 1.40 -13.13), rectum (SIR 4.49;) and pancreas , and for testis cancer in the medium term (SIR 5.94;. Leukaemia was significantly increased in the short term (SIR 6.78; CI 2.93 -13.36). The better survival observed is largely attributable to improved treatment, and the trend in reducing the toxicity of therapy should continue to reduce future health risks in testicular cancer survivors.

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Mortality and cancer incidence following radiotherapy for seminoma of the testis

Cited by 51 publications

References 24 publications

Increased mortality rates in young and middle-aged patients with malignant germ cell tumours

Increased mortality rates in young and middle-aged patients with malignant germ cell tumours

Radiotherapy for stages I and IIA/B testicular seminoma

Mortality and incidence of second cancers following treatment for testicular cancer

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