Mortality and life expectancy in persons with severe unipolar depression

Laursen, Thomas Munk; Musliner, Katherine L.; Benros, Michael E.; Vestergaard, Mogens; Munk‐Olsen, Trine

doi:10.1016/j.jad.2015.12.067

Cited by 210 publications

(137 citation statements)

References 15 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…It is well described that patients with a psychiatric history are particularly vulnerable regarding management of psychiatric disease and somatic comorbidity, making treatment decisions even more complex. Several studies have shown somatic comorbidity, excess mortality, and reduced life expectancy in this group of patients, also in relation to pregnancy . Somatic comorbidity was confirmed in Swedish studies, which showed that concomitant use of a variety of other drugs for somatic diseases was more prevalent among women taking antidepressants compared with the general population …”

Section: Introductionmentioning

confidence: 79%

Prescription drug use in pregnancy and variations according to prior psychiatric history

Ingstrup

Liu

Gasse

et al. 2017

Pharmacoepidemiology and Drug

Self Cite

View full text Add to dashboard Cite

Purpose: Prescription drug use during pregnancy has increased during the past decades.However, little is known about prescription drug use for high-risk pregnancies. We aimed to estimate the prevalence of redeemed prescriptions in Danish pregnant women with and without previous psychiatric history.Methods: A Danish population-based descriptive study of 981 392 pregnancies ending in live-born singletons by 586 988 women aged 15 to 55 years between 1997 and 2012, of which 113 449 (11.6%) pregnancies were by women with a psychiatric history prior to the index pregnancy. All prescription drugs redeemed during pregnancy were identified, and dispensing patterns among the women were reported by therapeutic classes of drugs, calendar year of childbirth, and trimester.Results: Overall, women with psychiatric history prior to pregnancy were more likely to fill a prescription (75.8%; 95% confidence interval [CI], 75.5-76.0%), compared with women with no psychiatric history (64.5%; 95% CI, 64.4-64.6%). The difference was observed even when psychotropic drug use was excluded and in all therapeutic classes except for antineoplastic and immunomodulating drugs. The most commonly prescribed drugs were anti-infectives. Approximately 44.7% (95% CI, 44.5-45.0%) of women with psychiatric history and 31.3% (95% CI, 31.2-31.4%) of women with no psychiatric history redeemed more than one therapeutic class of drugs.Conclusions: Women with a psychiatric history were more likely to redeem prescriptions during pregnancy across almost all drug classes, especially anti-infectives. Two thirds of all women redeemed at least one prescription drug during pregnancy and one third more than one drug class.

show abstract

Section: Introductionmentioning

confidence: 79%

Prescription drug use in pregnancy and variations according to prior psychiatric history

Ingstrup

Liu

Gasse

et al. 2017

Pharmacoepidemiology and Drug

Self Cite

View full text Add to dashboard Cite

show abstract

“…In older adults, depression’s dire consequences, including cognitive decline (Zahodne 2014), increased health care utilization (Shao 2017), functional decline (Callahan 1998, Barry 2009), and increased overall mortality (Laursen 2016) have prompted an aggressive search for predictors of therapeutic response, such as cerebrovascular disease (Taylor 2013, Aizenstein 2016), genetic factors (Marshe 2017), peripheral biomarkers and symptomatic phenotypes (Rutherford 2016, Nelson 2009). Gallo et al (2016) recently demonstrated that management of depression reduces mortality among depressed older adults with multimorbidity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Metabolic Syndrome on Late‐Life Depression: Associations with Disease Severity and Treatment Resistance

Mulvahill

Nicol

Dixon

et al. 2017

J American Geriatrics Society

View full text Add to dashboard Cite

Background Metabolic syndrome (MetSyn) is the co-occurrence of obesity with metabolic derangements. Prior research implicates MetSyn in prolonging the course of depression in older adults, but MetSyn’s effect on antidepressant response is unknown in this population. Objectives To determine if MetSyn and related metabolic dyscrasias are associated with decreased remission from depression among older adults treated pharmacologically for depression. Design Secondary analysis of a randomized controlled trial. Participants Adults 60 years and older with major depressive disorder (MDD, n=435) recruited from three academic medical centers in North America. Intervention Open-label, protocolized treatment with venlafaxine extended-release for twelve or more weeks. Main Measures Time-to-remission from depression, with remission defined as Montgomery-Åsberg Depression Rating Scale (MADRS) score ≤ 10 at last two visits. Key Results Of 435 participants (mean age 69.1 years), 222 (51%) met criteria for MetSyn at baseline; MetSyn was associated with greater severity (MADRS score) and chronicity of depression at baseline. Remission was achieved in 182 participants (42%). In the unadjusted analysis, MetSyn was associated with prolonged time-to-remission (hazard ratio for remission 0.71, 95% CI 0.52 – 0.95) but this relationship was not significant in the adjusted model; greater number of MetSyn components and lower HDL cholesterol had similar effects. Only diastolic blood pressure (DBP) was a significant predictor of time-to-remission before and after adjustment, with higher DBP predicting prolonged time-to-remission. Insulin sensitivity did not predict time-to-remission. Conclusion The presence of MetSyn in depressed, older adults is associated with greater symptom severity and chronicity of depression in our sample, which appear to account for the decreased antidepressant response observed among those with MetSyn. Additionally, our preliminary finding relating higher DBP with decreased antidepressant response bears further examination and replication.

show abstract

“…This mortality gap translates to a 10-15 year shortened life expectancy (Kessing et al, 2015, Laursen et al, 2016, Ösby et al, 2016.…”

Section: The Prevalence and Burden Of Metabolic Disease In People Witmentioning

confidence: 99%

Physical activity and metabolic disease among people with affective disorders: Prevention, management and implementation

Vancampfort

Stubbs

2017

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

Mortality and life expectancy in persons with severe unipolar depression

Cited by 210 publications

References 15 publications

Prescription drug use in pregnancy and variations according to prior psychiatric history

Prescription drug use in pregnancy and variations according to prior psychiatric history

Effect of Metabolic Syndrome on Late‐Life Depression: Associations with Disease Severity and Treatment Resistance

Physical activity and metabolic disease among people with affective disorders: Prevention, management and implementation

Contact Info

Product

Resources

About