Mortality by cancer in groups of the Belgian population with a moderately increased intake of arsenic

Buchet, Jean‐Pierre; Lison, Dominique

doi:10.1007/s004200050259

Cited by 42 publications

(26 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our current findings might remove some uncertainty about the association between cadmium exposure and cancer risk, doubt that comes from a large number of human studies on the association between cytogenetic endpoints and exposure to cadmium. 9,25 Our findings are also consistent with circumstantial evidence from a previous study of mortality statistics in north-east Belgium: 26 Buchet and Lison 26 noted that standardised rate ratios for death from lung cancer were unrelated to moderate environmental exposure to arsenic via air (ie, 0·3 g/m 3 ) or drinking water (ie, 20-50 g/L), but also recorded a higher proportion of death from lung cancer in areas with zinc smelters compared with areas without such plants. In 1992-94, the age-standardised incidence of lung cancer per 100 000 Flemish residents was 64·2 (113·6 in men and 16·0 in women).…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, we cannot exclude with certainty that cancer risk in the vicinity of smelters might be related to pollutants other than cadmium that are emitted during refining or smelting of zinc. However, on the basis of our current findings and an ecological mortality study 26 the possibility that arsenic might be involved is unlikely.…”

Section: Discussionmentioning

confidence: 67%

“…23 The general population is exposed to inorganic arsenic through inhalation of polluted dust particles, ingestion of contaminated food or water pumped from geological layers containing arsenic, and possibly through smoking. 26 24-h urinary excretion of arsenic is a biomarker of recent exposure (ie, about 3 days), and in unexposed people is usually less than 200 nmol per day. In 1985-89, geometric mean 24-h urinary arsenic excretion was 144 nmol (IQR 80-253) in Hechtel and Eksel, 158 nmol (106-227) in Balen, 373 nmol (253-547) in Overpelt and Neerpelt, and 570 nmol (394-827) in Lommel (figure 1).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Environmental exposure to cadmium and risk of cancer: a prospective population-based study

Nawrot

Plusquin

Hogervorst

et al. 2006

The Lancet Oncology

545

288

View full text Add to dashboard Cite

SummaryBackground Cadmium is a ubiquitous environmental pollutant, which accumulates in the human body such that 24-h urinary excretion is a biomarker of lifetime exposure. We aimed to assess the association between environmental exposure to cadmium and cancer.Methods We recruited a random population sample (n=994) from an area close to three zinc smelters and a reference population from an area with low exposure to cadmium. At baseline (1985-89), we measured cadmium in urine samples obtained over 24 h and in the soil of participants' gardens, and followed the incidence of cancer until June 30, 2004. We used Cox regression to calculate hazard ratios for cancer in relation to internal (ie, urinary) and external (ie, soil) exposure to cadmium, while adjusting for covariables.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Environmental exposure to cadmium and risk of cancer: a prospective population-based study

Nawrot

Plusquin

Hogervorst

et al. 2006

The Lancet Oncology

545

288

View full text Add to dashboard Cite

show abstract

“…Environmental contamination by As is a serious threat to human health in many parts of the world (Mandal and Suzuki 2002), and As can enter the human food chain through plants and animals. Soil contamination by As can occur in a wide range of sites (Buchet and Lison 1998).…”

Section: Introductionmentioning

confidence: 99%

Influence of the arbuscular mycorrhizal fungus Glomus mosseae on uptake of arsenate by the As hyperaccumulator fern Pteris vittata L.

et al. 2004

View full text Add to dashboard Cite

Influence of the arbuscular mycorrhizal fungus Glomus mosseae on uptake of arsenate by the As hyperaccumulator fern Pteris vittata L. Abstract We report for the first time some effects of colonization by an arbuscular mycorrhizal (AM) fungus (Glomus mosseae) on the biomass and arsenate uptake of an As hyperaccumulator, Pteris vittata. Two arsenic levels (0 and 300 mg As kg −1 ) were applied to an already contaminated soil in pots with two compartments for plant and hyphal growth in a glasshouse experiment. Arsenic application had little or no effect on mycorrhizal colonization, which was about 50% of root length. Mycorrhizal colonization increased frond dry matter yield, lowered the root/ frond weight ratio, and decreased frond As concentration by 33-38%. Nevertheless, transfer of As to fronds showed a 43% increase with mycorrhizal colonization at the higher soil As level. Frond As concentrations reached about 1.6 g kg −1 (dry matter basis) in non-mycorrhizal plants in the As-amended soil. Mycorrhizal colonization elevated root P concentration at both soil As levels and mycorrhizal plants had higher P/As ratios in both fronds and roots than did non-mycorrhizal controls.

show abstract

“…Enterline et al (1987) report lung cancer associated with air exposures above the Occupational Safety and Health (OSHA) standard of 10 g/m 3 . A general population exposed to chronic low level (0.3 g/m 3 ) contact with airborne arsenic experienced an elevated rate of lung cancer (Buchet and Lison, 1998). In the U.S., the average adult is exposed to total arsenic (organic and inorganic) at a rate of about 50 g /day from all sources (Agency for Toxic Substances and Disease Registry, 1993).…”

Section: Introductionmentioning

confidence: 99%

Spatial distributions of arsenic exposure and mining communities from NHEXAS Arizona

O'Rourke

Rogan

Jin

et al. 1999

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

Within the context of the National Human Exposure Assessment Survey (NHEXAS), metals were evaluated in the air, soil, dust, water, food, beverages, and urine of a single respondent. Potential doses were calculated for five metals including arsenic. In this paper, we seek to validate the potential dose calculations through spatial analysis of the data. Others report elevated arsenic concentrations in biological and environmental samples from residents of mining towns, particularly Ajo, Arizona. These reports led us to expect potential arsenic doses above the 90th percentile of the NHEXAS exposure distribution to be from residents of mining communities. Arsenic dose was calculated using media concentrations, time activity patterns, and published exposure factors. Of the 179 homes evaluated, 54 were in mining communities; 11 of these were considered separately for reasons of population bias. Of the 17 homes with the greatest potential arsenic doses, almost half (47%) were in mining communities. We evaluated the potential doses by media from nonmining and mining areas using the nonparametric Mann±Whitney U test. Statistically significant ( p = 0.05) differences were found between mining (n = 43) and nonmining sites (n = 122) for total exposure and for each of the following media: house dust, yard soil, outdoor air, beverage consumed, and water consumed. No differences were found in either food or indoor air of mining and nonmining areas. We eliminated outliers and repeated the test for all media; significance increased. Dietary, organic arsenic from fish consumption contributed to elevated arsenic exposure among people from nonmining communities and acted as an initial confounder. When controlling for fish consumption, we were able to validate our potential dose model using arsenic, particularly in Ajo. Further, we identified three mining communities lacking elevated arsenic exposure. Additional work is needed speciating the arsenic and evaluating health risks. The utilization of Geographic Information System facilitated spatial this project and paves the way for more sophisticated future spatial analyses.

show abstract

Mortality by cancer in groups of the Belgian population with a moderately increased intake of arsenic

Abstract: A low to moderate level of environmental exposure to inorganic arsenic (0.3 microgram As/m3 of air; 20-50 micrograms As/l of drinking water) does not seem to affect the causes of mortality, suggesting in particular nonlinearity of the dose-response relationship for arsenic and cancer.

Cited by 42 publications

References 6 publications

Environmental exposure to cadmium and risk of cancer: a prospective population-based study

Environmental exposure to cadmium and risk of cancer: a prospective population-based study

Influence of the arbuscular mycorrhizal fungus Glomus mosseae on uptake of arsenate by the As hyperaccumulator fern Pteris vittata L.

Spatial distributions of arsenic exposure and mining communities from NHEXAS Arizona

Contact Info

Product

Resources

About