Mortality Due to Polyomavirus Infection in Two Nightjars (Caprimulgus europaeus)

Arroube, Ana Sofia; Halami, Mohammad Yahya; Johne, Reimar; Dorrestein, Gerry M.

doi:10.1647/2008-007.1

Cited by 8 publications

(3 citation statements)

References 15 publications

(28 reference statements)

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“…Conversely, avian polyomavirus (APV) causes acute, sometimes fatal, disease in a variety of species and orders (Arroube et al, 2009; Johne and Müller, 2007; Lafferty et al, 1999) and was detected in nearly all organs of infected birds (Phalen et al, 1993). A phylogenetic analysis of polyomavirus genomes suggested that bird and mammalian polyomaviruses separated early in their evolutionary history and co-evolved with their hosts (Crandall et al, 2006; Pérez-Losada et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The structure of avian polyomavirus reveals variably sized capsids, non-conserved inter-capsomere interactions, and a possible location of the minor capsid protein VP4

et al. 2011

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Avian polyomavirus (APV) causes a fatal, multi-organ disease among several bird species. Using cryogenic electron microscopy and other biochemical techniques, we investigated the structure of APV and compared it to that of mammalian polyomaviruses, particularly JC polyomavirus and simian virus 40. The structure of the pentameric major capsid protein (VP1) is mostly conserved; however, APV VP1 has a unique, truncated C-terminus that eliminates an intercapsomere-connecting β-hairpin observed in other polyomaviruses. We postulate that the terminal β-hairpin locks other polyomavirus capsids in a stable conformation and that absence of the hairpin leads to the observed capsid size variation in APV. Plug-like density features were observed at the base of the VP1 pentamers, consistent with the known location of minor capsid proteins VP2 and VP3. However, the plug density is more prominent in APV and may include VP4, a minor capsid protein unique to bird polyomaviruses.

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Section: Introductionmentioning

confidence: 99%

The structure of avian polyomavirus reveals variably sized capsids, non-conserved inter-capsomere interactions, and a possible location of the minor capsid protein VP4

et al. 2011

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“…distinguished seven PyV clades, and pointed towards a complex evolutionary history [5]. The number of PyV has increased in the last few years; viruses have been detected in Californian sea lions (CSLPyV1) [18], bats (MyoPyV) [19], birds [20,21], in addition to the novel simian viruses. We have detected new polyomaviruses in apes (gorillas and bonoboos), Old World monkeys, like hamadryas baboon and mandrill, and in capuchin monkeys and spider monkeys, both New World monkeys (unpublished data; EMBL: FR692182-FR692189).…”

Section: Resultsmentioning

confidence: 99%

Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies

Deuzing

Fagrouch

Groenewoud

et al. 2010

Virol J

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The complete nucleotide sequences of three chimpanzee polyomavirus genetic variants were determined. Phylogenetic analysis indicated that the viruses form two different genotypes of ChPyV. Comparison with other primate polyomaviruses revealed a putative agnogene, and an unusually long VP1 open reading frame. The transcriptional control regions (TCR) of the viruses were extremely short (155 nucleotides), and highly conserved amongst the genotypes. Analysis of the TCR from different chimpanzee subspecies, and from a series of tissues from five individuals confirmed its genetic stability, and also indicates that double-infections with different genotypes can occur.

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“…These viruses have been shown to infect a wide range of avian and mammalian host species, although most have been shown to be species specific (26). Avian polyomavirus (APV) was first discovered in 1981 (10) and is known to be the causative agent in budgerigar fledgling disease (33) as well as causing fatal disease in a variety of other species (5,15,16,27,30). APV affects a range of avian hosts; however, the clinical presentation, distribution of lesions, and epidemiological effects of the virus on a population vary markedly between susceptible species (5,10,13).…”

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confidence: 99%

Disease Screening of Three Breeding Populations of Adult Exhibition Budgerigars (Melopsittacus undulatus) in New Zealand Reveals a High Prevalence of a Novel Polyomavirus and Avian Malaria Infection

Baron

Howe²,

Varsani

et al. 2014

Avian Diseases

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SUMMARY. Disease surveillance is vital to the management of New Zealand's endemic and threatened avian species. Three infectious agents that are potential threats to New Zealand's endemic birds include avian polyomavirus (APV), beak and feather disease virus (BFDV), and avian malaria. All three agents have been reported in New Zealand; however, possible reservoir populations have not been identified. In this communication, we report the first study of APV, BFDV, and avian malaria in introduced adult exhibition budgerigars (Melopsittacus undulatus) in New Zealand. Blood samples were collected from 90 living adult budgerigars from three breeding locations in the North Island of New Zealand. An overall APV prevalence of 22% was determined using a broad-spectrum nested PCR that amplified the major capsid protein VP1 gene of polyomavirus. Phylogenetic analysis of the VP1 gene revealed a unique isolate of APV, which had a sequence divergence of 32% to previously reported budgerigar fledgling disease strains and 33% to the recently reported New Zealand finch isolate. All of the budgerigars sampled were found to be PCR negative for BFDV, and an overall prevalence of 30% was detected by PCR for avian malaria. Sequencing revealed the presence of ubiquitous malarial strains and also the potentially destructive Plasmodium relictum strain. The results of this study suggest that both APV and avian malaria are present in New Zealand adult budgerigars, and our study highlights the need for further studies to determine whether these pathogens in captive bird populations may be a threat or spill over into New Zealand's endemic and threatened avifauna and whether prevention and control methods need to be implemented. RESUMEN. Un estudio de enfermedades de tres poblaciones reproductoras de periquitos australianos (Melopsittacus undulatus)de exhibición en Nueva Zelanda revela una alta prevalencia de una infección por un nuevo poliomavirus y por la malaria aviar.La vigilancia de enfermedades es vital para el manejo de las especies aviares endémicas y amenazadas de Nueva Zelanda. Tres agentes infecciosos que son amenazas potenciales para las aves endémicas de Nueva Zelanda incluyen al poliomavirus aviar (APV), el virus de la enfermedad del pico y plumas (BFDV), y la malaria aviar. Los tres agentes se han reportado en Nueva Zelanda, sin embargo, no han sido identificadas poblaciones de posibles reservorios. En este artículo se presenta el primer estudio de poliomavirus aviar, del virus del pico y las plumas y de la malaria aviar en periquitos australianos (Melopsittacus undulatus) adultos de exhibición introducidos a Nueva Zelanda. Se recolectaron muestras de sangre de 90 periquitos adultos vivos de tres lugares de cría en la Isla Norte de Nueva Zelanda. Se determinó una prevalencia general de poliomavirus aviar de 22% utilizando un método de PCR anidado que amplifica el gene de la proteína principal de la cápside VP1 del poliomavirus. El análisis filogenético del gene VP1 reveló un aislamiento único de poliomavirus, que tenía una dive...

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Mortality Due to Polyomavirus Infection in Two Nightjars (Caprimulgus europaeus)

Cited by 8 publications

References 15 publications

The structure of avian polyomavirus reveals variably sized capsids, non-conserved inter-capsomere interactions, and a possible location of the minor capsid protein VP4

The structure of avian polyomavirus reveals variably sized capsids, non-conserved inter-capsomere interactions, and a possible location of the minor capsid protein VP4

Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies

Disease Screening of Three Breeding Populations of Adult Exhibition Budgerigars (Melopsittacus undulatus) in New Zealand Reveals a High Prevalence of a Novel Polyomavirus and Avian Malaria Infection

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