Mortality in a cohort of cement workers in a plant of Central Italy

Giordano, F; Dell’Orco, Valerio; Fantini, Fiorella; Grippo, Francesco; Perretta, Vladimiro; Testa, Angelo; Figà–Talamanca, Irene

doi:10.1007/s00420-011-0678-8

Cited by 7 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For lung cancer mortality, the pattern of SMRs was similar to that seen for all cancers with four of the seven studies reporting SMRs with CIs overlapping the null, two studies showing slightly decreased SMRs (SMR=0.53, 95% CI 0.27 to 0.95)12 and (SMR=0.56, 95% CI 0.32 to 0.89),6 and one reporting an increase for lung cancer (n=85 cases; PMR=2.05, 95% CI 1.65 to 2.627; figure 2). The meta-SMR for lung cancer mortality was 0.93 (95% CI 0.62 to 1.39).…”

Section: Resultssupporting

confidence: 52%

“…Half of the studies of all cancers combined reported CIs overlapping the null5 10 12 while two others showed slightly decreased SMRs for all cancers for cement workers (SMR=0.80, 95% CI 0.69 to 0.92)8 and (SMR=0.64, 95% CI 0.48 to 0.82),6 and one showed a slight increase (PMR=1.30, 95% CI 1.13 to 1.49) 7. The meta-SMR for all cancers combined was 0.94 (95% CI 0.76 to 1.16).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A review and meta-analysis of cancer risks in relation to Portland cement exposure

et al. 2014

View full text Add to dashboard Cite

Workers engaged in the production of Portland cement may come into contact with potential occupational hazards, but existing epidemiological studies show wide variation in risk estimates for cancer incidence and mortality in relation to cement exposure. This report identified studies of cement workers and associations with cancer incidence and mortality in a systematic review and meta-analysis. A systematic review according to the PRISMA guidelines was conducted to identify studies of Portland cement workers and cancer outcomes. Meta-analyses were performed using random effects models for all cancers combined and for each cancer site with three or more reported measures of risk. A total of 26 studies were included in the review (14 occupational cohort studies and 12 case-control studies). Overall, the meta-relative risks did not provide convincing evidence for increased risks of any cancers in relation to cement exposure. Meta-SMR and 95% CIs were 0.94 (0.76 to 1.16) for six studies reporting all cancers combined, 0.93 (0.62 to 1.39) for seven studies reporting on lung cancer, 1.07 (0.72 to 1.59) for five studies reporting on stomach cancer, and 1.05 (0.79 to 1.40) for four studies reporting on colorectal cancer. Meta-relative risks for cancer incidence were similarly null for all sites with the exception of colorectal cancer which had a borderline statistically significant elevated risk (SIR=1.38, 95% CI 1.02 to 1.88). Overall, the meta-relative risks calculated across 26 published studies do not provide evidence of increased risks for cancer in relation to cement exposure.

show abstract

Section: Resultssupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

A review and meta-analysis of cancer risks in relation to Portland cement exposure

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Dab and colleagues, in a French cohort study with a follow up period of 15 years, also failed to demonstrate an elevated mortality from respiratory cancer among workers of a cement industrial plant [9]. Giordano et al, in an Italian cohort study, found a significantly elevated mortality for respiratory cancer, exclusively in a group of cement workers with previous exposure to asbestos [10]. On the other hand, Smailyte and coworkers in a cohort study among workers of the Lithuanian cement industry plan, found an excess in Standardised Mortality Ratio (SMR) for lung cancer [7].…”

Section: Discussionmentioning

confidence: 99%

“…There is contradictory evidence of an association between exposure to cement dust and lung function impairment [3,4]. This is also the case for the association between exposure to cement dust and respiratory tract malignancies, in particular lung and larynx cancer [5-10]. Nevertheless, it is notable that almost all studies evaluating the association between cement dust and respiratory cancer have included subjects from one or two cement factories, resulting in a low generalizability of the observed results.…”

Section: Introductionmentioning

confidence: 99%

Respiratory tract mortality in cement workers: a proportionate mortality study

Rachiotis

Drivas²,

Κostikas

et al. 2012

BMC Pulm Med

View full text Add to dashboard Cite

BackgroundThe evidence regarding the association between lung cancer and occupational exposure to cement is controversial. This study investigated causes of deaths from cancer of respiratory tract among cement workers.MethodsThe deaths of the Greek Cement Workers Compensation Scheme were analyzed covering the period 1969-1998. All respiratory, lung, laryngeal and urinary bladder cancer proportionate mortality were calculated for cement production, maintenance, and office workers in the cement industry. Mortality from urinary bladder cancer was used as an indirect indicator of the confounding effect of smoking.ResultsMortality from all respiratory cancer was significantly increased in cement production workers (PMR = 1.91; 95% CI 1.54 to 2.33). The proportionate mortality from lung cancer was significantly elevated (PMR = 2.05; 95% CI 1.65 to 2.52). A statistically significant increase in proportionate mortality due to respiratory (PMR = 1.7; 95% CI 1.2 to 2.34). and lung cancer (PMR = 1.67;95% CI = 1.15-2.34) among maintenance workers has been observed. The PMR among the three groups of workers (production, maintenance, office) did differ significantly for lung cancer (p = 0.001), while the PMR for urinary bladder cancer found to be similar among the three groups of cement workers.ConclusionCement production, and maintenance workers presented increased lung and respiratory cancer proportionate mortality, and this finding probably cannot be explained by the confounding effect of smoking alone. Further research including use of prospective cohort studies is needed in order to establish a causal association between occupational exposure to cement and risk of lung cancer.

show abstract

“…Because of the volatility of cement dust, the main targets in the human body are the respiratory system, skin, and eyes. It has been reported that cement dust in work environments are associated with a higher prevalence of chronic respiratory symptoms and reduced lung function [10][11][12]; however, no difference in mortality rates was seen in a cohort study of cement workers in a plant in Central Italy [20]. Furthermore, a recent survey found that cement workers were at a higher risk of developing COPD (prevalence of 18.8%) than the administrative workers of the same factory (prevalence of 4.8%), independent of smoking habits [21].…”

Section: Discussionmentioning

confidence: 89%

Methodology of an Observational Cohort Study for Subjects with Chronic Obstructive Pulmonary Disease in Dusty Areas Near Cement Plants

Hong¹,

Kwon²,

Lee³

et al. 2014

J Pulm Respir Med

View full text Add to dashboard Cite

Chronic Obstructive Pulmonary Disease (COPD) occurs in genetically susceptible individuals by chronic exposure to environmental factors. Although cigarette smoking is a major risk factor for this disease, environmental factors including vapor, gas, dust, and fumes can also impact lung function. Emissions from cement plants are known to have negative health effects; however, the effects of cement dust on COPD subjects living near cement plants have not been fully investigated. We plan to conduct a study to observe clinical outcomes of COPD areas near the cement plants in Korea. Here, we present methodology for an observational cohort study. Cement plants are mostly located in the Kangwon and Chungbuk provinces in Korea. COPD subjects in these areas are recruited for medical examinations consisting of a questionnaire of environmental exposure and health habits, symptom severity, pulmonary function testing, and computed tomography. Blood and urine samples are obtained and subjects will be followed up over 10 years. The patient cohort of this study differs from other COPD study populations in that the participants have been living in dusty areas near cement plants; we therefore termed this cohort COPD in dusty area.

show abstract

Mortality in a cohort of cement workers in a plant of Central Italy

Cited by 7 publications

References 22 publications

A review and meta-analysis of cancer risks in relation to Portland cement exposure

A review and meta-analysis of cancer risks in relation to Portland cement exposure

Respiratory tract mortality in cement workers: a proportionate mortality study

Methodology of an Observational Cohort Study for Subjects with Chronic Obstructive Pulmonary Disease in Dusty Areas Near Cement Plants

Contact Info

Product

Resources

About