Mortality in Sepsis and its relationship with gender

Abstract

Background and Objective:Sepsis remains a leading cause of death across the world, carrying a mortality rate of 20–50%. Women have been reported to be less likely to suffer from sepsis and to have a lower risk of mortality from sepsis compared to men. The objective of this study was to determine the relationship between gender and mortality in sepsis, and compare cytokine profiles of male and female patients.Methods:This was a prospective case series on 97 patients admitted with sepsis. Clinical and microbiological data was gathered, blood samples were collected for cytokine (IL-10, IL-6 and TNFα) levels and patients were followed up for clinical outcome.Results:There were 54% males and 46% females, with no significant difference of age or comorbids between genders. Respiratory tract infection was the commonest source of sepsis, and was more common in females (60%) compared to males (39%) (p=0.034). Males had a higher mortality (p=0.048, RR 1.73) and plasma IL-6 level(p=0.040) compared to females. Mean IL-6 plasma level was significantly (p<0.01) higher in patients who died vs. who recovered.Conclusion:Our study shows that males with sepsis have a 70% greater mortality rate, and mortality is associated with a higher IL-6 plasma level.

Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis

“…The incidence of sepsis is high and the mortality rate reaches nearly 20 to 50% [4]. To date, although considerable progress of anti-infective therapy and organ function support technology has been made, severe sepsis and sepsis shock are still a lethal and intractable pathological condition [5].…”

Accuracy for mortality prediction with additive biomarkers including interleukin-6 in critically ill patients: a multicenter prospective observational study

“…Logistic regression analyses to predict 28-day mortality were performed again to derive the linear combination of the baseline model (Day 2 SOFA score) and an additional biomarker as measured based on the best time point just described. Some biomarkers were analyzed with sex as suggested in other studies [23,24]. The ROC curves were drawn and AUROC was compared between the baseline model and combination model developed with the additional biomarker.…”

Correlation between Blood Types and Intraabdominal Infection A Preliminary Study

“…20 In the study, age is not likely a factor correlated to the occurrence of sepsis, although study of Martin et al (2006) found those with extreme age (over 65 years) are more vulnerable to Gram-negative germs. 6 The study also showed no relationship of gender to the occurrence of sepsis, while as study of Nasir et al (2015) showed that male with sepsis had a greater chance up to 70% to death than female, as it associated with higher plasma interleukin 6 (IL-6) levels. 21 What has the study showed significantly was the correlation between blood transfusion (p = 0.0001) to IAI with OR 0.02 with 95% confidence interval, by means that transfusion has a 0.02 chance leading to sepsis.…”

“…6 The study also showed no relationship of gender to the occurrence of sepsis, while as study of Nasir et al (2015) showed that male with sepsis had a greater chance up to 70% to death than female, as it associated with higher plasma interleukin 6 (IL-6) levels. 21 What has the study showed significantly was the correlation between blood transfusion (p = 0.0001) to IAI with OR 0.02 with 95% confidence interval, by means that transfusion has a 0.02 chance leading to sepsis. There were studies focused on the risk of bacterial contamination in preparation of hematopoietic progenitors, skin cleansing methods, changes in time of intact blood storage, cold storage of platelet suspensions, leukoreduction of red blood cells, the development of rapid screening tests for bacteria, and methods for inactivation of platelet component bacteria.…”