BACKGROUND: The wound healing process includes inflammation, proliferation, and remodelling phases, the main features of which are inflammation, neoangiogenesis, and epithelialization. Hyperbaric oxygen therapy (HBOT) is one modality postulated to improve wound healing. The objective of this study was to determine whether HBOT could improve selected features of burn wound healing in an experimental rabbit model. METHODS: Researchers conducted an experimental study with 36 rabbits given second-degree burns. Subjects were separated into two groups: a control group (n = 18) and an intervention group that was given HBOT at 2.4 atmospheres absolute for 6 days (n = 18). The main outcome measure was wound healing. RESULTS: Compared with the control group, the HBOT group showed more robust inflammatory cells ( P = .025) and epithelialization ( P = .024), but no significant difference in angiogenesis ( P = .442). CONCLUSIONS: The authors conclude that HBOT may improve second-degree burn healing by increasing inflammatory cell migration and re-epithelialization.

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Background Methylene blue (MB) has been found to have unique analgesic property through temporary disruption of sensory nerve conduction. In anorectal surgery, MB is widely used as a biologic stain but the analgesic effect has never been studied. Thus, a literature review completed with critical appraisal is required to find out its efficacy. Methods A review has been run to find out its efficacy. Literature search proceeded in database sites, namely, PubMed, EBSCO, Cochrane, Wiley, and ProQuest using the following keywords: “anorectal” OR “hemorrhoid” OR “anal fistula” OR “anal fissure” OR “anal abscess” OR “anal pruritus” AND “methylene blue” AND “analgesic”; then the critical appraisal and its implication were discussed. Result There were 491 articles in full text found, and four studies met the inclusion criteria. Two studies were focused on the evaluation of VAS in hemorrhoid surgery whereas the rest were focused on the evaluation of symptom score in anal pruritus. Conclusions A study with level of evidence 2 on VAS showed the efficacy. The rest showed insufficient evidence due to variations of anorectal surgery and the methods and techniques of MB application. A further prospective clinical study is required.

Feracrylum merupakan obat topikal yang mengandung garam besi poliakrilat 0.05 sampai 0.5%. Obat ini terbukti memiliki efek antibakteri dan efektif untuk mengobati luka bakar. Suatu uji klinik tentang efektivitas dan keamanan dari feracrylum dibandingkan dengan silver sulfadiazin (SSD) telah dilakukan pada penderita luka bakar, dengan metode studi terbuka, acak, berpembanding. Feracrylum dan SSD dioleskan tiap hari pada masing-masing satu sisi badan dan hasilnya diobservasi selama 11 hari. Tujuh dari 8 pasien dapat menyelesaikan studi ini. Pada hari 7 dan 11 reepitelisasi meningkat pada sisi tubuh yang mendapat feracrylum yang terlihat dengan berkurangnya luas lesi.