Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome

Meier, Sandra; Dalsgaard, Søren; Mortensen, Preben Bo; Leckman, James F.; Plessen, Kerstin Jessica

doi:10.1002/mds.26939

Cited by 28 publications

(20 citation statements)

References 35 publications

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“…The associations between mental disorders and mortality highlight the prominent role of comorbid substance use disorders with respect to both elevated mortality rates and reduced life expectancy. These findings are in line with previous research 9,19‐21 that observed higher mortality rates in patients with attention deficit/hyperactivity and other behavioral disorders, schizophrenia, bipolar disorder or depression, if they additionally experienced a comorbid substance use disorder.…”

Section: Discussionsupporting

confidence: 93%

Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population‐based cohort study

et al. 2020

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The nature and prevalence of combinations of mental disorders and their associations with premature mortality have never been reported in a comprehensive way. We describe the most common combinations of mental disorders and estimate excess mortality associated with these combinations. We designed a population‐based cohort study including all 7,505,576 persons living in Denmark at some point between January 1, 1995 and December 31, 2016. Information on mental disorders and mortality was obtained from national registers. A total of 546,090 individuals (10.5%) living in Denmark on January 1, 1995 were diagnosed with at least one mental disorder during the 22‐year follow‐up period. The overall crude rate of diagnosis of mental disorders was 9.28 (95% CI: 9.26‐9.30) per 1,000 person‐years. The rate of diagnosis of additional mental disorders was 70.01 (95% CI: 69.80‐70.26) per 1,000 person‐years for individuals with one disorder already diagnosed. At the end of follow‐up, two out of five individuals with mental disorders were diagnosed with two or more disorder types. The most prevalent were neurotic/stress‐related/somatoform disorders (ICD‐10 F40‐F48) and mood disorders (ICD‐10 F30‐F39), which – alone or in combination with other disorders – were present in 64.8% of individuals diagnosed with any mental disorder. Mortality rates were higher for people with mental disorders compared to those without mental disorders. The highest mortality rate ratio was 5.97 (95% CI: 5.52‐6.45) for the combination of schizophrenia (ICD‐10 F20‐F29), neurotic/stress‐related/somatoform disorders and substance use disorders (ICD‐10 F10‐F19). Any combination of mental disorders was associated with a shorter life expectancy compared to the general Danish population, with differences in remaining life expectancy ranging from 5.06 years (95% CI: 5.01‐5.11) to 17.46 years (95% CI: 16.86‐18.03). The largest excess mortality was observed for combinations that included substance use disorders. This study reports novel estimates related to the “force of comorbidity” and provides new insights into the contribution of substance use disorders to premature mortality in those with comorbid mental disorders.

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Section: Discussionsupporting

confidence: 93%

Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population‐based cohort study

et al. 2020

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“…New and important findings this year involve the previously unappreciated risk of death in TDs. Meier et al (2017) demonstrated that mortality rates are elevated in TS and other TDs, with or without comorbidities. In a very large epidemiological study, TDs in adults were associated with a four-fold higher risk of suicide, with the risk not explained by other psychiatric illness such as major depression ( Fernández de la Cruz et al , 2017b ).…”

Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2017

2018

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This is the fourth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2017 relevant to Tourette syndrome and other tic disorders. The authors briefly summarize reports they consider most important or interesting. The highlights from 2018 article is being drafted on the Authorea online authoring platform, and readers are encouraged to add references or give feedback on our selections using the comments feature on that page. After the calendar year ends, the article is submitted as the annual update for the Tics collection on F1000Research.

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“…Although TS and chronic tic disorders were associated with a higher risk of premature death, irrespective of the presence of comorbidities such as ADHD, OCD, and substance abuse, in a prospective cohort study [ 163 ], adults with TS reported good psychosocial functioning, attainment of social milestones such as graduating from school, securing a job, and getting married, and high quality of life [ 39 , 164 ]. As many people still have misconceptions about tic disorders (e.g., tics are due to psychological issues or individuals with tics cannot lead normal lives), providing anticipatory guidance at the time of the diagnosis of TS can reassure patients and their families [ 164 ].…”

Section: Comorbiditiesmentioning

confidence: 99%

A Comprehensive Review of Tic Disorders in Children

Ueda

Black

2021

JCM

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Tics are characterized by sudden, rapid, recurrent, nonrhythmic movement or vocalization, and are the most common movement disorders in children. Their onset is usually in childhood and tics often will diminish within one year. However, some of the tics can persist and cause various problems such as social embarrassment, physical discomfort, or emotional impairments, which could interfere with daily activities and school performance. Furthermore, tic disorders are frequently associated with comorbid neuropsychiatric symptoms, which can become more problematic than tic symptoms. Unfortunately, misunderstanding and misconceptions of tic disorders still exist among the general population. Understanding tic disorders and their comorbidities is important to deliver appropriate care to patients with tics. Several studies have been conducted to elucidate the clinical course, epidemiology, and pathophysiology of tics, but they are still not well understood. This article aims to provide an overview about tics and tic disorders, and recent findings on tic disorders including history, definition, diagnosis, epidemiology, etiology, diagnostic approach, comorbidities, treatment and management, and differential diagnosis.

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Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome

Abstract: These results are of clinical significance for clinicians and advocacy organizations. Several factors may contribute to this increased risk of premature death, and more research mapping out these factors is needed. © 2017 International Parkinson and Movement Disorder Society.

Cited by 28 publications

References 35 publications

Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population‐based cohort study

Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population‐based cohort study

Tourette syndrome research highlights from 2017

A Comprehensive Review of Tic Disorders in Children

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