MoS2–graphene hybrid nanostructures enhanced localized surface plasmon resonance biosensors

Abstract

We propose a new configuration of a localized surface plasmon resonance (LSPR) biosensor that is based on MoS 2 -graphene hybrid structures for ultrasensitive detection of molecules. The performance parameters of the proposed biosensor are defined in terms of absorption and sensitivity. Our study show that sensitivity can be greatly increased either by adding a bilayer MoS 2 /graphene on the Au nanoparticles or by adding the MoS 2 layer or the graphene layer on the surface of the Au nanoparticles. The absorption curves for the proposed LSPR biosensor are analyzed and compared with the conventional biosensors without MoS 2 /graphene. By optimizing the structure of the sensor, we find that the sensitivity as high as 360 nm/RIU can be achieved with 8-layers of MoS 2 and 10-layers of graphene. In addition, we show that the sensitivity can be controlled by changing the number of the monolayer of MoS 2 and/or graphene. Finally, we show that this sensor can detect successfully impure water after absorption of target single-stranded DeoxyriboNucleic Acid (ssDNA) biomolecules.

Recent progress of UCNPs–MoS2 nanocomposites as a platform for biological applications

“…This special layer morphology grants MoS 2 a high specific surface area, allowing it to be loaded with more substances in a smaller volume. 50 Mohamed et al 51 constructed a AuNPs/MoS 2 -graphene biosensor by utilizing the properties of the high specific surface area and strong conducting energy of MoS 2 . In contrast to conventional local surface plasmon resonance biosensors, this sensor exhibited a 57.7% enhancement in sensitivity, facilitating the precise and high-quality detection of biomolecules.…”

2D Van der Waals Heterostructures for Chemical Sensing

“…A localized surface plasmon resonance biosensor based on MoS 2 –graphene was proposed to detect DNA. [ 172 ] The schematic representation of the AuNPs/MoS 2 /graphene sensor is shown in Figure , and the resulting sensor displayed a significantly improved sensitivity compared to that without MoS 2 and graphene. In the optimized structure of eight‐layer MoS 2 and ten‐layer graphene, the highest sensitivity of 360 nm RIU −1 was achieved due to their large surface‐to‐volume ratio, and their strong conductivity.…”

“…Reproduced with permission. [ 172 ] Copyright 2020, Elsevier Ltd. Besides the theoretical study of sensing DNA hybridization, an experimental work on a D‐shaped fiber SPR sensor based on a CVD MoS 2 /CVD graphene was developed for the detection of glucose.…”

“…The input wave source (monochromatic plane wave) is also shown. Reproduced with permission [172]. Copyright 2020, Elsevier Ltd.…”

Review of Interface Modification Based on 2D Nanomaterials for Surface Plasmon Resonance Biosensors

“…106,107 Excellent photoelectric and biological functionalization characteristics of the above layered materials have pushed the exploration of their application in SPR sensitivity enhancement. 59,108 The unique super-large specific surface area makes it easy to closely fit with the chip surface. Flexible and diverse preparation methods of 2D van der Waals layered materials enable high-quality 2D crystals to be widely obtained, and advanced processing methods including chemical vapor deposition (CVD) allow 2D crystal thin films to be grown directly on the chip surface, 109 reducing the defects in the process of material transfer and modification.…”