Mosaic Hydrogels: One‐Step Formation of Multiscale Soft Materials

Leng, Lian; McAllister, Arianna; Zhang, Boyang; Radišić, Milica; Günther, Axel

doi:10.1002/adma.201201442

Cited by 118 publications

(111 citation statements)

References 55 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…However, alginate by itself negatively impacts collagen type one deposition from dermal fibroblasts, potentially making them a non-ideal polymer for skin substitutes[80]. Alginate has been largely considered an ideal polymer for skin printers, devices that seed skin cells onto prefabricated biodegradable scaffolds, due to its ionic cross-linking mechanism[81,82]. Skin printer technology will inevitably advance and thus the use of alginate in skin substitutes will increase.…”

Section: Components Of a Skin Substitutementioning

confidence: 99%

“…Due to the novelty of this emerging technology, most of these methods have not been tested specifically for skin substitutes, yet one form of 3D printing using laser printing has been proven to be effective providing initial evidence of skin regeneration in in vivo mouse models[183,184]. The use of microfluidics has also been used with preliminary positive evidence for skin substitutes, however further research must be completed before any conclusions are to be made[185,186]. Other 3D printing methods have previously been compared and contrasted in current literature and will not be repeated here[182,187], but it is important to address the overall limitations of this newer technology.…”

Section: Creating Skin Substitutesmentioning

confidence: 99%

See 1 more Smart Citation

Methodologies in creating skin substitutes

Nicholas

Jeschke

Amini-Nik

2016

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

The creation of skin substitutes has significantly decreased morbidity and mortality of skin wounds. Although there are still a number of disadvantages of currently available skin substitutes, there has been a significant decline in research advances over the past several years in improving these skin substitutes. Clinically most skin substitutes used are acellular and do not use growth factors to assist wound healing, key areas of potential in this field of research. This article discusses the five necessary attributes of an ideal skin substitute. It comprehensively discusses the three major basic components of currently available skin substitutes: scaffold materials, growth factors, and cells, comparing and contrasting what has been used so far. It then examines a variety of techniques in how to incorporate these basic components together to act as a guide for further research in the field to create cellular skin substitutes with clinically better results.

show abstract

Section: Components Of a Skin Substitutementioning

confidence: 99%

Section: Creating Skin Substitutesmentioning

confidence: 99%

Methodologies in creating skin substitutes

Nicholas

Jeschke

Amini-Nik

2016

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…Moreover, it has been shown that using the so-called multilayermicrofluidic devices, mosaic hydrogels with a well-defined spatial composition of materials, cells or pores can be prepared. (Leng, et al, 2012) Based on the oligonucleotide pairs complementarity principle, gel interfaces can be specifically assembled. (Qi, et al, 2013;Deschner, et al, 2014) Setting the spatial/surface presentation of the complementary sequences in the different units allows the formation of controlled assemblies.…”

Section: Specific Assemblingmentioning

confidence: 99%

Towards the design of 3D multiscale instructive tissue engineering constructs: Current approaches and trends

Oliveira

Reis

Mano

2015

Biotechnology Advances

View full text Add to dashboard Cite

The design of 3D constructs with adequate properties to instruct and guide cells both in vitro and in vivo is one of the major focuses of tissue engineering. Successful tissue regeneration depends on the favorable crosstalk between the supporting structure, the cells and the host tissue so that a balanced matrix production and degradation are achieved. Herein, the major occurring events and players in normal and regenerative tissue are overviewed. These have been inspiring the selection or synthesis of instructive cues to include into the 3D constructs. We further highlight the importance of a multiscale perception of the range of features that can be included on the biomimetic structures. Lastly, we focus on the current and developing tissue-engineering approaches for the preparation of such 3D constructs: top-down, bottom-up and integrative. Bottom-up and integrative approaches present a higher potential for the design of tissue engineering devices with multiscale features and higher biochemical control than top-down strategies, and are the main focus of this review.

show abstract

“…they lack vascularization and few feature melanocytes) and not all approaches are amenable to higherthroughput applications. Fortunately, these challenges are known and are being addressed by a burgeoning field that has yet to show its full potential [5,6]. Table 1 summarizes recent bioprinting approaches relevant to skin production and the cell viability associated with each.…”

mentioning

confidence: 98%