The modern stage of development of research in the field of regional economics involves the application of a wide coverage of regional economic systems data. Their overall totals form a digital trace of the development of the territory. A scientific digital footprint of the key factors and patterns of creative industries in the second-tier cities of Siberia and the Urals, reflected in the web application, allows imagining, comparing and comprehending the current state and perspectives of creative industries in second-tier cities. In this article, considering the demography dynamics and diversification of creative business activity as well as data on created enterprises, the author highlights the cities that are interested in creative reindustrialization the most – oil and gas specialize cities of Khanty-Mansiysk autonomous okrug – Megion, Nefteyugansk, Nizhnevartovsk, Nyagan, and Uray. Second-tier cities that display a relatively higher level of economic activity diversification encompass Novokuznetsk, Biysk, Nyagan, Prokopyevsk, Rubtsovsk, Sysert, and Uray. At the same time large industrial centers in regions provide more favorable conditions for the development of creative enterprises. Whereas in the regional context, the Tomsk region and Altai Krai lag behind other regions in absolute terms. Thus, the first obvious strategical step in municipal development through creative reindustrialization is using the essential opportunities highlighted by demography conditions, mainly in oil and gas towns. Whereas large industrial centers in regions could use more favorable conditions for the development of creative enterprises for its further development.