Most Important Outcomes Research Papers on Cardiovascular Disease in Women

Gupta, Aakriti; Lampropulos, Julianna F.; Bikdeli, Behnood; Mody, Purav; Chen, Ruijun; Kulkarni, V.; Dharmarajan, Kumar

doi:10.1161/circoutcomes.112.970202

Cited by 13 publications

(7 citation statements)

References 56 publications

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“…This study from the REPOSI cohort of hospitalized elderly patients admitted acutely to internal or geriatric wards has shown the existence of gender differences in terms of demographic profile, clinical characteristics and outcomes. Although the attention of the scientific community on gender-related issues is high [22], there is little evidence specifically stemming from hospitalized patients with multiple diseases admitted to internal medicine and geriatric wards. Our observation that clinical profiles and disease distributions varied according to gender would support the existence of a gender dimorphism in the elderly.…”

Section: Discussionmentioning

confidence: 99%

Gender-differences in disease distribution and outcome in hospitalized elderly: Data from the REPOSI study

Corrao

Santalucia

Argano

et al. 2014

European Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Gender-differences in disease distribution and outcome in hospitalized elderly: Data from the REPOSI study

Corrao

Santalucia

Argano

et al. 2014

European Journal of Internal Medicine

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“…14 Moreover, research on cardiovascular conditions increasingly demonstrates that there are clinically meaningful sex differences and gender disparities in the occurrence, management and outcomes of CVD. 15 16 In what follows, we highlight some recent findings relevant to sex differences in the area of CVDs. Most of these findings come from studies in HICs.…”

Section: Introductionmentioning

confidence: 94%

Women's health: a new global agenda

et al. 2016

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Global efforts to improve the health of women largely focus on improving sexual and reproductive health. However, the global burden of disease has changed significantly over the past decades. Currently, the greatest burden of death and disability among women is attributable to non-communicable diseases (NCDs), most notably cardiovascular diseases, cancers, respiratory diseases, diabetes, dementia, depression and musculoskeletal disorders. Hence, to improve the health of women most efficiently, adequate resources need to be allocated to the prevention, management and treatment of NCDs in women. Such an approach could reduce the burden of NCDs among women and also has the potential to improve women's sexual and reproductive health, which commonly shares similar behavioural, biological, social and cultural risk factors. Historically, most medical research was conducted in men and the findings from such studies were assumed to be equally applicable to women. Sex differences and gender disparities in health and disease have therefore long been unknown and/or ignored. Since the number of women in studies is increasing, evidence for clinically meaningful differences between men and women across all areas of health and disease has emerged. Systematic evaluation of such differences between men and women could improve the understanding of diseases, as well as inform health practitioners and policymakers in optimising preventive strategies to reduce the global burden of disease more efficiently in women and men.

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“…Because of improvements in the treatment and prevention of AMI, mortality from coronary artery disease has significantly decreased over the past decades ( 34 ). However, this reduction in mortality has been less pronounced in women than in men ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Sex-Based Differences in Autologous Cell Therapy Trials in Patients With Acute Myocardial Infarction: Subanalysis of the ACCRUE Database

Haller

Gyöngyösi

Chacon‐Alberty³

et al. 2021

Front. Cardiovasc. Med.

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Background: Sex-based differences are under-studied in cardiovascular trials as women are commonly underrepresented in dual sex studies, even though major sex-based differences in epidemiology, pathophysiology, and outcomes of cardiovascular disease have been reported. We examined sex-based differences in patient characteristics, outcome, and BM-CD34+ frequency of the ACCRUE (Meta-Analysis of Cell-based CaRdiac studies) database involving patients with acute myocardial infarction (AMI) randomized to autologous cell-based or control treatment.Methods: We compared baseline characteristics and 1-year follow-up clinical data: composite major adverse cardiac and cerebrovascular events (primary endpoint), and changes in left ventricular ejection fraction (LVEF), end-diastolic (EDV), and end-systolic volumes (ESV) (secondary efficacy endpoint) in women and men (N = 1,252; 81.4% men). Secondary safety endpoints included freedom from hard clinical endpoints.Results: In cell-treated groups, women but not men had a lower frequency of stroke, AMI, and mortality than controls. The frequency of BM-CD34+ cells was significantly correlated with baseline EDV and ESV and negatively correlated with baseline LVEF in both sexes; a left shift in regression curve in women indicated a smaller EDV and ESV was associated with higher BM-CD34+ cells in women.Conclusions: Sex differences were found in baseline cardiovascular risk factors and cardiac function and in outcome responses to cell therapy.

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Most Important Outcomes Research Papers on Cardiovascular Disease in Women

Cited by 13 publications

References 56 publications

Gender-differences in disease distribution and outcome in hospitalized elderly: Data from the REPOSI study

Gender-differences in disease distribution and outcome in hospitalized elderly: Data from the REPOSI study

Women's health: a new global agenda

Sex-Based Differences in Autologous Cell Therapy Trials in Patients With Acute Myocardial Infarction: Subanalysis of the ACCRUE Database

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