Mother-daughter pairs: spinal and femoral bone densities and dietary intakes

Lutz, Josephine; Tesar, Rogene

doi:10.1093/ajcn/52.5.872

Cited by 81 publications

(42 citation statements)

References 26 publications

(8 reference statements)

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“…We observed significant motherdaughter correlations in BMD, consistent with other parent-offspring studies, (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) which did not change substantially with adjustment for potential covariates, such as age and anthropometry. Daughters, particularly premenopausal daughters, of mothers with ''normal BMD'' had greater BMD at all sites than daughters of mothers who had established osteoporosis.…”

Section: Discussionsupporting

confidence: 89%

“…Low bone mass is associated with increased risk of fracture but is considered a necessary, not a sufficient, predisposing factor. (3) Previous studies have reported significant and relatively consistent parent-offspring correlations in bone mineral density (BMD) (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and have shown that a family history of osteoporosis and/or fracture is associated with an increased risk of low BMD and fracture. (14)(15)(16)(17)(18)(19) Some, (14,16) but not all, (6,13,(17)(18)(19) of these studies confirmed a family history of osteoporosis or fracture via medical records or radiographs.…”

Section: Introductionmentioning

confidence: 99%

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Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Danielson

Cauley

Baker

et al. 1999

Journal of Bone and Mineral Research

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The familial resemblance in bone mineral density (BMD) and calcaneal broadband ultrasound attenuation (BUA) was examined in 207 mother-daughter pairs. Mothers were participants in the Study of Osteoporotic Fractures. Three groups of daughters were recruited based on their maternal history of ''fracture,'' ''low BMD'' without fracture (< 0.58 g/cm 2 , t-score < −2.5), and ''normal BMD'' without fracture (> 0.67 g/cm 2 , t-score > −1.6). Data on other potentially heritable factors known to influence BMD and BUA were also collected. BMD was measured at the hip, spine, whole body, and calcaneus. Calcaneal BUA was assessed using the Walker-Sonix UBA 575. Total hip and femoral neck BMD were significantly lower (5.0-8.0%, p < 0.017) among daughters, in particular premenopausal daughters, of mothers with established osteoporosis (''fracture'' or ''low BMD'') compared with daughters of mothers at lower risk of osteoporosis (''normal BMD''). BUA did not differ across daughter groups. Lifestyle characteristics (dietary calcium, smoking, physical activity) were not highly correlated in mothers and daughters. Height, weight, and body composition were significantly correlated within mother-daughter pairs and could be a potential mechanism by which BMD is inherited. Among pre-and postmenopausal daughters, heritability estimates ranged from 50-63% and 34-48%, respectively. Heritability for calcaneal BUA (53%) was evident among postmenopausal daughters only. In conclusion, familial association in BMD was strongest among premenopausal daughters. Estimates of heritability suggest that maternal BMD and BUA are important independent predictors of BMD and BUA among daughters, reinforcing the importance of prevention and early intervention among women with a positive family history of osteoporosis. (J Bone Miner Res 1999;14:102-110)

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Danielson

Cauley

Baker

et al. 1999

Journal of Bone and Mineral Research

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show abstract

“…Bone mass has a very strong genetic component: twin and family studies reveal that 50 to 90% of the variance in BMD is caused by genetic factors (Pocock et al 1987;Slemenda et al 1991;Lutz & Tesar, 1990;Gueguen et al 1995;Hunter et al 2001). Whole genome-wide linkage studies (Wilson et al 2003;Devoto et al 1998;Kammerer et al 2003;Karasik et al 2004;Ralston et al 2005) have been launched to search for genes underlying BMD variation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Environmental Factors and Gender on the Heritability of Bone Mineral Density and Bone Size

Sham

Paterson

et al. 2006

Annals of Human Genetics

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SummaryBone mineral density (BMD), a risk factor for osteoporosis, is believed to be under genetic control. The effect of environmental factors and gender on the heritability of BMD and bone size is ill-defined. In this study, heritability estimates (h 2 ) were determined in 3,320 southern Chinese subjects from 1,019 families using the variance components model. The h 2 for age, weight and height-adjusted BMD was 0.63-0.71 for females, and 0.74-0.79 for males; and for bone size, 0.44-0.64 for females and 0.32-0.86 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking and alcohol consumption altered the h 2 differently in males and females. The proportion of variance in BMD and bone size explained by all covariates varied between skeletal sites, but was consistently greater in females than males. A significant gender difference was observed in the genetic variance of BMD and bone size at the hip but not the spine. In conclusion, a gender difference was observed in the degree of heritability of BMD and bone size at specific skeletal sites. Environmental influences contributed variably at different sites in the two sexes.

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“…At the end of the growth period, a large variance in bone mineral density (BMD) 1 and content (BMC), in either the axial or the appendicular skeleton, is observed both in healthy females and males (4)(5)(6)(7)(8). Many genetic and environmental factors have been suggested to influence bone mass accumulation during this period (9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.

Bonjour¹,

Carrié²,

Ferrari³

et al. 1997

J. Clin. Invest.

512

339

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High calcium intake during childhood has been suggested to increase bone mass accrual, potentially resulting in a greater peak bone mass. Whether the effects of calcium supplementation on bone mass accrual vary from one skeletal region to another, and to what extent the level of spontaneous calcium intake may affect the magnitude of the response has, however, not yet been clearly established. In a doubleblind, placebo-controlled study, 149 healthy prepubertal girls aged 7.9 Ϯ 0.1 yr (mean Ϯ SEM) were either allocated two food products containing 850 mg of calcium (Ca-suppl.) or not (placebo) on a daily basis for 1 yr. Areal bone mineral density (BMD), bone mineral content (BMC), and bone size were determined at six sites by dual-energy x-ray absorptiometry. The difference in BMD gain between calcium-supplemented (Ca-suppl.) and placebo was greater at radial (metaphysis and diaphysis) and femoral (neck, trochanter, and diaphyses) sites (7-12 mg/cm 2 per yr) than in the lumbar spine (2 mg/cm 2 per yr). The difference in BMD gains between Ca-suppl. and placebo was greatest in girls with a spontaneous calcium intake below the median of 880 mg/d. The increase in mean BMD of the 6 sites in the low-calcium consumers was accompanied by increased gains in mean BMC, bone size, and statural height. These results suggest a possible positive effect of calcium supplementation on skeletal growth at that age. In conclusion, calcium-enriched foods significantly increased bone mass accrual in prepubertal girls, with a preferential effect in the appendicular skeleton, and greater benefit at lower spontaneous calcium intake.

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Mother-daughter pairs: spinal and femoral bone densities and dietary intakes

Cited by 81 publications

References 26 publications

Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters Study

Effect of Environmental Factors and Gender on the Heritability of Bone Mineral Density and Bone Size

Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.

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