2010
DOI: 10.1086/656284
|View full text |Cite
|
Sign up to set email alerts
|

Mother‐to‐Child Transmission of HIV‐2 Infection from 1986 to 2007 in the ANRS French Perinatal Cohort EPF‐CO1

Abstract: Care for HIV-2-infected pregnant women rests on expert opinion. The mother-to-child transmission residual rate (0.07%-2.2%) argues for systematic treatment: protease inhibitor-based HAART for women requiring antiretrov

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
22
0
1

Year Published

2012
2012
2018
2018

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 49 publications
(24 citation statements)
references
References 43 publications
1
22
0
1
Order By: Relevance
“…HIV-2 infection represents a unique model of attenuated retroviral infection, characterized by slow disease progression associated with prolonged maintenance of a normal CD4 + cell count [2]; low infectivity, with a high proportion of patients with a spontaneous undetectable plasma viral load in the absence of antiretroviral drugs [3]; and a low rate of transmission [4, 5]. …”
Section: Introductionmentioning
confidence: 99%
“…HIV-2 infection represents a unique model of attenuated retroviral infection, characterized by slow disease progression associated with prolonged maintenance of a normal CD4 + cell count [2]; low infectivity, with a high proportion of patients with a spontaneous undetectable plasma viral load in the absence of antiretroviral drugs [3]; and a low rate of transmission [4, 5]. …”
Section: Introductionmentioning
confidence: 99%
“…IV-2 infection, mainly restricted to West Africa (1), is characterized by a slow disease progression associated with a slow decline in CD4 T cell counts (2,3), a low rate of sexual or vertical transmission (4,5), lower viral replication than HIV-1 (6,7), and natural resistance to non-nucleoside reverse transcriptase inhibitors, fusion inhibitors (enfuvirtide), and several protease inhibitors, necessitating a specific approach for HIV-2-infected patient monitoring, different than that for HIV-1 infection (8,9).…”
mentioning
confidence: 99%
“…Calculations of the nucleic acid sequence data estimated the date of introduction of HIV-2 in humans to 1940 (±20 years), which is very close to the predicted introduction of HIV-1 [7]. HIV-2 is less pathogenic than HIV-1, which results in a prolonged period until the signs of immunodeficiency and AIDS develop, and a mother-to-child transmission rate of around 7‰ to 2%, compared to 10–40% in those infected with HIV-1 [8]. The prevalence of HIV-2 in some African communities has reached approximately 10–16% over time, but this is currently being overtaken by HIV-1 [9].…”
Section: Origin Of the Types And Groups Of Hiv And Its Epidemiologymentioning
confidence: 80%