Tuberculosis (TB) is an infectious airborne disease caused by the bacterium Mycobacterium tuberculosis (Narendran & Swaminathan, 2016).Although it is an age-old life-threatening disease, currently it is the leading cause of death among children who experience infectious diseases worldwide (UNICEF, 2020). In 2020, out of the estimated 9.9 million persons who fell ill with TB globally, children below the age of 15 years accounted for about 11% (1.1 million) (World Health Organization, 2021a, 2021b. In Ghana, 5% of all new TB case notifications in 2020 were among children below the age of 15 years (World Health Organization, 2021a). Ill children living with TB will require considerable parental or guardian care to survive. Mothers typically play the traditional role of primary caregivers for children in most settings, including Ghana (Kyu et al., 2018). As such, it is important to learn if and how the mothers' burden of care associated with their caregiver role changes when their children fall ill with TB and must be nursed back to health.