Introduction: Prostate cancer is the most common and the second leading cause of cancer death in men in most developed countries. Prostate biopsy remains the gold standard to confirm its diagnosis. Material and Method: This is a prospective study during 6 months, starting from 1st of February to 31st of July 2022. It included all patients who underwent a prostate biopsy that was carried out either following a high tPSA or due to an abnormal digital rectal examination. Results: We performed digitally guided biopsies in 32 patients from whom, average age was 72.43 years and elevation of total PSA was the main reason (71.88%) behind biopsies. The mean total PSA level was 45.69 ng/ml. The tissues removed were essentially prostate tissues, malignant in 28.12% of cases with adenocarcinoma as the only histological type. Conclusion: Prostate biopsy remains the gold standard for the diagnosis of prostate cancer. When indicated in front of an abnormal digital rectal examination, the probabilities of positivity of the samples are high even in the case of digitally guided biopsies in an under-equipped environment.