Motility of the Human Ureter, with Special Reference to the Effect of Indomethacin

Angelo‐Khattar, M.; Thulesius, Olav; Nilsson, T.; Cherian, Thomas; Joseph, Leon

doi:10.3109/00365598509180267

Cited by 47 publications

(15 citation statements)

References 7 publications

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“…sodium salicylate and aspirin which also inhibit prostaglandin synthe- sis. In agreement with our finding, in previous studies indomcthacin inhibited ureteral motil ity in vitro [25,26]. In our experiments, we added Bk into the bathing medium after the ef fect of prostaglandin synthesis blockers reach ed a steady level.…”

Section: Discussionsupporting

confidence: 92%

Prostaglandin-lndependent Decrease of Sheep Ureter Contractility Induced by Bradykinin

Kaygisiz

Dönmez²,

Uyar

et al. 1995

Kidney Blood Press Res

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The machanisms that mediate the actions of bradykinin on ureteral motility are poorly defined and mediation via prostaglandins has not been examined. Therefore, the effects of bradykinin on contractility and the possible mediator role of prostaglandins have been investigated in sheep ureter. At the concentrations of 10^-8, 10^-7 and 10^-6M, bradykinin elicited marked reductions in contractile force. When ureteral strips were treated separately with 10^-6M indomethacín, 2x10^-6M sodium salicylate and 10^-5 M aspirin, each drug produced a significant decrease in contractile force. In strips in which prostaglandin synthesis was inhibited by the above concentrations of indomethacin, sodium salicylate and aspirin, 10^-7M bradykinin significantly decreased the contractility. From these data, we concluded that in ureter bradykinin decreases contractility via a mechanism not involving prostaglandin generation.

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Section: Discussionsupporting

confidence: 92%

Prostaglandin-lndependent Decrease of Sheep Ureter Contractility Induced by Bradykinin

Kaygisiz

Dönmez²,

Uyar

et al. 1995

Kidney Blood Press Res

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“…Many in vitro physiological and pharmacological stud ies of the ureter [10,11] have shown an absence of sponta neous contractile activity. The present study shows that the ability of in vitro ureteral segments to generate sponta neous contractions depends on the method of cutting the ureter.…”

Section: Discussionmentioning

confidence: 99%

Relationship of the Structure of Ureteral Muscularis to in vitro Spontaneous Contractions

et al. 1995

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We investigated the anatomical structure of the smooth muscle layers of the mid portion of the canine ureter. In transverse sections the inner muscle bundles appear to be oriented longitudinally and the outer muscle bundles appear to be oriented in a circular configuration. In sections cut parallel with the longitudinal axis of the ureter, the inner and outer bundles appear to be oblique and are oriented in a mesh-line manner. In oblique sections, cut parallel with the helically oriented ureteral muscle, bundles appear to be oriented in a lengthwise configuration. These anatomical studies show that canine ureteral smooth muscle is composed of spiral fibers in a mesh structure and that helical muscle strips which include a significant percentage of continuous bundles have a greater capacity to generate spontaneous contractions in vitro than do transverse and longitudinal muscle strips.

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“…As reference we had to rely on sheep gallbladder strips which apparently qualita tively responded to cholinergic stimulation like human specimens. The selection of ovine gallbladders was a com promise since these specimens are always readily avail able from freshly slaughtered sheep and we have previous extense experience with smooth muscle preparations from sheep [9] which basically responded in a similar way to human specimens [10]. In our study we chose carbachol as a stimulant of contractility since we found that the nat urally occurring agonist cholecystokinin in a series of 12 experiments only resulted in a 59% efficacy (maximal response) as compared to carbachol (results not shown).…”

Section: Discussionmentioning

confidence: 99%

“…As expected, the inhibition of ERA occurred after a certain latency period since prostaglandin inhibition requires some time and the bathing fluid was not changed upon administration, therefore probably some stimulating activity still remained in the bath. Large amplitude rhythmic contractions have previously been reported in a small number of cases with cholecystitis [12] and the cyclooxygenase inhibitor indomethacin has suc cessfully been used clinically in the treatment of acute bil iary pain [ 13], We previously described a similar situation in the human ureter where spontaneous large amplitude motility is governed by prostaglandins, and increased Gallbladder Motility Digestion 1997:58:368-372 rhythmic contractions were detected in ureteral irritation and ureteral disease [10].…”

Section: Discussionmentioning

confidence: 99%

Gallbladder Motility in Laparoscopic Cholecystectomy Specimens

et al. 1997

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In vitro contractility of human and sheep gallbladders to cholinergic stimulation with carbachol and the effects of indomethacin on abnormal rhythmic activity were studied. Once hundred and thirdy-two gallbladders were obtained at laparoscopic cholecystectomy, 38 from patients with acute and 94 with chronic cholecystitis. In addition, 27 specimens of sheep gallbladders served as controls. Fundal preparations from patients with cholecystitis exhibit hypocontractility: no response in 72% or in the remainder a significantly reduced maximal contraction to carbachol. Regionally graded motor responses favoring propulsion of bile were abnormal in 44% ofthe gallbladders studied with more forceful contractions of the duct compared to the fundus. Abnormal early rhythmic activity (ERA) of fundal preparations was only detected in gallbladders of patients (in 33%) but never in controls. In 80% of these, ERA was blocked or reduced by indomethacin which can be interpreted as evidence for a prostaglandin-mediated inflammatory response. We conclude that gallbladder motility in cholelithiasis secondary to muscarinic stimulation is reduced and regionally graded motor responses favoring bile expulsion are impaired. ERA can be blocked by indomethacin.

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Motility of the Human Ureter, with Special Reference to the Effect of Indomethacin

Cited by 47 publications

References 7 publications

Prostaglandin-lndependent Decrease of Sheep Ureter Contractility Induced by Bradykinin

Prostaglandin-lndependent Decrease of Sheep Ureter Contractility Induced by Bradykinin

Relationship of the Structure of Ureteral Muscularis to in vitro Spontaneous Contractions

Gallbladder Motility in Laparoscopic Cholecystectomy Specimens

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