Motion perception in the ipsilateral visual field of a hemispherectomized patient

Marx, Esther; Stephan, Thomas; Bense, Sandra; Yousry, Tarek; Dieterich, Marianne; Brandt, Thomas

doi:10.1007/s00415-002-0842-x

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…They argued that this may be mediated via strengthened, interhemispheric, SC commissural connections, which may be targeting the ipsilateral hemisphere via the pulvinar. This is in general agreement with prior reports by Bittar et al (1999) and Marx et al (2002), but differs from those of Goebel et al (2001) and Vaina et al (2014), who reported extrastriate cortex activation only in the lesioned hemisphere contralateral to the scotoma. Other studies (Nelles et al 2002(Nelles et al , 2007 have reported bilateral extrastriate cortex activation when the visual stimulus is presented in the anopic field.…”

Section: Capacity Of the Visual Cortex For Reorganization After Cortisupporting

confidence: 92%

Probing Human Visual Deficits with Functional Magnetic Resonance Imaging

Smirnakis

2016

Annu. Rev. Vis. Sci.

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Much remains to be understood about visual system malfunction following injury. The resulting deficits range from dense, visual field scotomas to mild dysfunction of visual perception. Despite the predictive value of anatomical localization studies, much patient-to-patient variability remains regarding (a) perceptual abilities following injury and (b) the capacity of individual patients for visual rehabilitation. Visual field perimetry is used to characterize the visual field deficits that result from visual system injury. However, standard perimetry mapping does not always precisely correspond to underlying anatomical or functional deficits. Functional magnetic resonance imaging can be used to probe the function of surviving visual circuits, allowing us to classify better how the pattern of injury relates to residual visual perception. Identifying pathways that are potentially modifiable by training may guide the development of improved strategies for visual rehabilitation. This review discusses primary visual cortex lesions, which cause dense contralateral scotomas.

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Section: Capacity Of the Visual Cortex For Reorganization After Cortisupporting

confidence: 92%

Probing Human Visual Deficits with Functional Magnetic Resonance Imaging

Smirnakis

2016

Annu. Rev. Vis. Sci.

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“…In the case of anatomical hemispherectomy where all visual cortical regions of one hemisphere have been removed, residual vision is dependent upon the contribution of the remaining hemisphere as demonstrated by brain-imaging methods. Thus, it was shown that visual stimulation of the blind hemifield in hemispherectomy patients activates visual cortical areas in the remaining hemisphere [55, 56]. A more recent, DTI study by Leh and colleagues [52] highlighted the pathway by which the visual information presented to the blind field reaches the contralateral visual cortex.…”

Section: Discussionmentioning

confidence: 99%

Adaptive Neuroplastic Responses in Early and Late Hemispherectomized Monkeys

2012

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Behavioural recovery in children who undergo medically required hemispherectomy showcase the remarkable ability of the cerebral cortex to adapt and reorganize following insult early in life. Case study data suggest that lesions sustained early in childhood lead to better recovery compared to those that occur later in life. In these children, it is possible that neural reorganization had begun prior to surgery but was masked by the dysfunctional hemisphere. The degree of neural reorganization has been difficult to study systematically in human infants. Here we present a 20-year culmination of data on our nonhuman primate model (Chlorocebus sabeus) of early-life hemispherectomy in which behavioral recovery is interpreted in light of plastic processes that lead to the anatomical reorganization of the early-damaged brain. The model presented here suggests that significant functional recovery occurs after the removal of one hemisphere in monkeys with no preexisting neurological dysfunctions. Human and primate studies suggest a critical role for subcortical and brainstem structures as well as corticospinal tracts in the neuroanatomical reorganization which result in the remarkable behavioral recovery following hemispherectomy. The non-human primate model presented here offers a unique opportunity for studying the behavioral and functional neuroanatomical reorganization that underlies developmental plasticity.

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