Recently, simulators find application not only in the aeronautics, but also in other fields of technology, like robotics, marine etc. Computer-based trainings are offered almost with every modern technology product placed in the market. In the paper the application of simulators to train pilots of mobile platforms (like aircraft, cars, sea-vessels) is considered. The simulator sickness appears due to difficulties in simulating the motion and environment "properly" in the simulator. Similar symptoms, called a virtual reality sickness may be observed within the community of computer game players. The main reason for occurrence of the simulator sickness is that external stimuli (motion and/or vision) give misleading information to a human brain. The aim of this research was to find the relation between the architecture and the technical parameters of different types of simulators and occurrence of the simulator sickness. The focus of this study is the architecture of the simulator and its technical parameters that may influence unfavorable operator reactions during training, such as moving platform, screen size, simulated models, graphics quality, etc. The paper is based on a wide literature review, and it is an introduction to the future experimental research.