Motor Band Sign in Primary Lateral Sclerosis: A Case Report Proposing the Need for an Imaging Biomarker

Valaparla, Vijaya Lakhsmi; Lobaina, Milena; Patel, Chilvana; Patel, Anand Vilaschandra

doi:10.7759/cureus.36121

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Newcastle-Ottawa scale Cochrane risk of bias Kwan et al [13] Good quality-8/9 stars Low risk of bias Chakraborty et al [2] Fair quality-5/9 stars Moderate risk of bias due to no blinding Boll et al [10] Good quality-7/9 stars Low risk of bias Boll et al [45] Good quality-8/9 stars Low risk of bias Roeben et al [9] Good quality-7/9 stars Low risk of bias Prabhu and Sajja [5] Fair quality-4/9 stars High risk of bias due to no blinding, no control group Budhu et al [17] Fair quality-5/9 stars Moderate risk of bias due to no blinding Makkawi et al [24] Fair quality-6/9 stars Moderate risk of bias due to no blinding Pai et al [15] Fair quality-5/9 stars Moderate risk of bias due to no blinding Chung et al [7] Good quality-8/9 stars Low risk of bias Zanovello et al [16] Good quality-7/9 stars Low risk of bias Valaparla et al [46] Fair quality-6/9 stars Moderate risk of bias due to no blinding…”

Section: Studymentioning

confidence: 99%

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Motor Band Sign in Motor Neuron Diseases Using Magnetic Resonance Imaging: A Systematic Review

Mohammadi,

Ghaderi

2023

Acta Neurologica Scandinavica

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Motor neuron diseases (MNDs) like amyotrophic lateral sclerosis (ALS) are progressive neurodegenerative disorders affecting upper and lower motor neurons (UMN and LMN). Magnetic resonance imaging (MRI) often reveals a “motor band sign” (MBS) of hypointensity along the precentral gyri in ALS, considered a radiologic hallmark. This review comprehensively summarizes the literature on MBS in ALS and related MNDs using multiple MRI techniques. A systematic search was conducted in the PubMed and Scopus databases to identify relevant studies on MBS in MNDs published until August 2023. Twelve studies were included. Most patients had UMN involvement at the onset. MBS was correlated with UMN impairment severity. Susceptibility-weighted imaging (SWI) detected MBS in the majority of MND patients. The use of SWI could be particularly useful in detecting MBS, and it should be considered as part of the routine clinical MRI protocols. Recent studies suggest that hypointensity and atrophy of the primary motor cortex (M1) and nearby regions can be used as MRI markers of UMN impairment in MNDs. Other MRI techniques like T2-weighted (T2-w), T2 ∗ -w, and fluid-attenuated inversion recovery (FLAIR) also showed characteristic changes. Furthermore, quantitative susceptibility mapping (QSM) is an advanced MRI technique that allows sensitive quantification of iron deposition and has shown promise for accurately detecting MBS in MNDs. The findings suggest that MR neuroimaging techniques can provide valuable insights into the pathophysiology of MND and can be used to detect biomarkers such as MBS. The review demonstrates that advanced MRI techniques can detect cortical and white matter changes reflecting upper motor neuron degeneration in MNDs like ALS. To find out how sensitive and suggestive the MBS is in MNDs and neurodegenerative movement disorders and how well it works as a prognostic indicator, we will need to do more research that combines comprehensive prospective and longitudinal research.

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Section: Studymentioning

confidence: 99%

“…64% of patients[16]. Lastly, Valaparla et al identified sulcal hypointensities in T2-w and SWI images in the precentral regions on both sides[46].…”

mentioning

confidence: 98%

Motor Band Sign in Motor Neuron Diseases Using Magnetic Resonance Imaging: A Systematic Review

Mohammadi,

Ghaderi

2023

Acta Neurologica Scandinavica

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“…The sensitivity of SWI is particularly high when it comes to detecting deoxygenated blood and mineral deposits within the brain [4]. The MBS has also been observed in other neurodegenerative movement disorders [1, 5, 6], such as Parkinson's disease [5–7], Alzhimer's disease [5–8], and Huntington's disease [9].…”

Section: Figurementioning

confidence: 99%

Motor band sign or biomarker

Ghaderi,

Mohammadi

2023

iRADIOLOGY

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Proteomic profiling of the brain from the <i>wobbler</i> mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein

et al. 2023

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The wobbler mouse is a widely used model system of amyotrophic lateral sclerosis and exhibits progressive neurodegeneration and neuroinflammation in association with skeletal muscle wasting. This study has used wobbler brain preparations for the systematic and mass spectrometric determination of proteome-wide changes. The proteomic characterization of total protein extracts from wobbler specimens was carried out with the help of an Orbitrap mass spectrometer and revealed elevated levels of glia cell marker proteins, i.e., glial fibrillary acidic protein and the actin-binding protein coronin. In contrast, the abundance of the actin-binding protein neurabin and the scaffolding protein named piccolo of the presynaptic cytomatrix were shown to be reduced. The increased abundance of glial fibrillary acidic protein, which is frequently used in neuropathological studies as a marker protein of glial scar formation, was confirmed by immunoblotting. In analogy, the proteomic profiling of the brain from another established murine model of motor neuron disease, the SOD1mouse, also showed increased levels of this intermediate filament protein. This suggests that neurodegenerative processes are associated with astrogliosis in both the wobbler and SOD1 brain.

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Motor Band Sign in Primary Lateral Sclerosis: A Case Report Proposing the Need for an Imaging Biomarker

Cited by 3 publications

References 8 publications

Motor Band Sign in Motor Neuron Diseases Using Magnetic Resonance Imaging: A Systematic Review

Motor Band Sign in Motor Neuron Diseases Using Magnetic Resonance Imaging: A Systematic Review

Motor band sign or biomarker

Proteomic profiling of the brain from the <i>wobbler</i> mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein

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