Motor Cortex Excitability Changes in Mild Alzheimer's Disease Are Reversed by Donepezil

Balla, Christina; Noordhout, Alain Maertens De; Pépin, Jean

doi:10.1159/000360617

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Some factors could be disease-specific, such as fluctuations in blood glucose levels in T2DM, though, importantly, glucose levels (within the range of 80–200 mg/dL, specified a priori ) were not found to influence variability in the present study. Interestingly, the AD group showed numerically higher reproducibility coefficients for nearly all measures, including RMT, SICI and iTBS aftereffects, which several studies in AD have shown to be abnormal and/or predictive of disease severity or response to treatment ( Liepert et al, 2001 ; Di Lazzaro et al, 2004 ; Koch et al, 2012 , 2015 ; Brem et al, 2013 ; Balla et al, 2014 ). It is possible, however unlikely, that some aspect of the Sham treatment (e.g., daily study visits or interaction with study staff) that the AD group underwent had some stabilizing effect on their neurophysiology.…”

Section: Discussionmentioning

confidence: 95%

Reproducibility of Single-Pulse, Paired-Pulse, and Intermittent Theta-Burst TMS Measures in Healthy Aging, Type-2 Diabetes, and Alzheimer’s Disease

Fried

Jannati

Davila-Pérez

et al. 2017

Front. Aging Neurosci.

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Background: Transcranial magnetic stimulation (TMS) can be used to assess neurophysiology and the mechanisms of cortical brain plasticity in humans in vivo. As the use of these measures in specific populations (e.g., Alzheimer’s disease; AD) increases, it is critical to understand their reproducibility (i.e., test–retest reliability) in the populations of interest.Objective: Reproducibility of TMS measures was evaluated in older adults, including healthy, AD, and Type-2 diabetes mellitus (T2DM) groups.Methods: Participants received two identical neurophysiological assessments within a year including motor thresholds, baseline motor evoked potentials (MEPs), short- and long-interval intracortical inhibition (SICI, LICI) and intracortical facilitation (ICF), and MEP changes following intermittent theta-burst stimulation (iTBS). Cronbach’s α coefficients were calculated to assess reproducibility. Multiple linear regression analyses were used to investigate factors related to intraindividual variability.Results: Reproducibility was highest for motor thresholds, followed by baseline MEPs, SICI and LICI, and was lowest for ICF and iTBS aftereffects. The AD group tended to show higher reproducibility than T2DM or controls. Intraindividual variability of baseline MEPs was related to age and variability of RMT, while the intraindividual variability in post-iTBS measures was related to baseline MEP variability, intervisit duration, and Brain-derived neurotrophic factor (BDNF) polymorphism.Conclusion: Increased reproducibility in AD may reflect pathophysiological declines in the efficacy of neuroplastic mechanisms. Reproducibility of iTBS aftereffects can be improved by keeping baseline MEPs consistent, controlling for BDNF genotype, and waiting at least a week between visits.Significance: These findings provide the first direct assessment of reproducibility of TMS measures in older clinical populations. Reproducibility coefficients may be used to adjust effect- and sample size calculations for future studies.

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Section: Discussionmentioning

confidence: 95%

Reproducibility of Single-Pulse, Paired-Pulse, and Intermittent Theta-Burst TMS Measures in Healthy Aging, Type-2 Diabetes, and Alzheimer’s Disease

Fried

Jannati

Davila-Pérez

et al. 2017

Front. Aging Neurosci.

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“…Dementia can be associated with a progressive deterioration in multiple brain functions [4]. It can sometimes affect cognition, behavior and other psychological functions, and frequently limits mobility [4][5][6]. The risk of dementia increases with age [7].…”

Section: Introductionmentioning

confidence: 99%

“…Pneumonia is one of the most common secondary complications and a key cause of mortality in the advanced stages of the disease [14,15]. Deterioration in motor function can also occur in the early stages [6,16,17]. Movement slowness, gait disturbance, postural instability and falls are common [6,16,18,19].…”

Section: Introductionmentioning

confidence: 99%

“…Deterioration in motor function can also occur in the early stages [6,16,17]. Movement slowness, gait disturbance, postural instability and falls are common [6,16,18,19]. Exercise and physical activities are associated with shortterm improvements in motor performance and functional abilities in some individuals living with dementia [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Music Cued Exercises for People Living with Dementia:A Systematic Review

Gomaa

Wittwer

Grenfell

et al. 2018

International Journal of Physiotherapy

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Background: Dementia can be associated with motor and non-motor disorders such as cognitive impairment, depression, and behavioral disturbance. The symptoms typically progress gradually over time. Music-cued exercises have been of therapeutic interest in recent years, especially to enable people with chronic neurological diseases to move more easily and to experience greater well-being. Objective: To investigate whether music-cued exercises are more effective than usual care for the management of motor and non-motor symptoms in people living with dementia.Methods: Systematic searching of the international literature was conducted in January 2018. Keywords were searched through electronic databases including MEDLINE, CINAHL, Embase, PsycINFO, PubMed, Scopus, the Web of Science, Science Direct, Wiley online library, and JOVE. The Cochrane collaboration tool was used to assess the risk of bias of the randomized controlled trials (RCTs). The Downs and Black checklist assessed the quality of non-RCTs.Results: Twelve studies met the eligibility criteria, including 4 RCTs. Three investigated the effects of music-cued exercises on motor performance, four examined non-motor outcomes, four quantified the level of exercise participation, and one examined both motor and non-motor outcomes. The included studies were of modest to low quality. Conclusion:There is growing evidence for the beneficial effects of music-cued exercises for people living with dementia. Enjoyable music and physical exercises matched to rhythmical music appear to have benefits for some individuals. The dosage of music-cued exercise is a key determinant of the motor and non-motor outcomes in people living with a variety of forms of dementia.

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Possible role of metal ionophore against zinc induced cognitive dysfunction in d-galactose senescent mice

2016

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Metal ionophores are considered as potential anti-dementia agents, and some are currently undergoing clinical trials. Many metals are known to accumulate and distribute abnormally in the aging brain. Alterations in zinc metal homeostasis in the glutaminergic synapse could contribute to ageing and the pathophysiology of Alzheimer's disease (AD). The present study was designed to investigate the effect of metal ionophores on long term administration of zinc in D-galactose induced senescent mice. The ageing model was established by combined administration of zinc and D-galactose to mice for 6 weeks. A novel metal ionophore, PBT-2 was given daily to zinc-induced d-galactose senescent mice. The cognitive behaviour of mice was monitored using the Morris Water Maze. The anti-oxidant status and amyloidogenic activity in the ageing mouse was measured by determining mito-oxidative parameters and deposition of amyloid β (Aβ) in the brain. Systemic administration of both zinc and D-galactose significantly produced memory deficits, mito-oxidative damage, heightened acetylcholinesterase enzymatic activity and deposition of amyloid-β. Treatment with PBT-2 significantly improved behavioural deficits, biochemical profiles, cellular damage, and curbed the deposition of APP in zinc-induced senescent mice. These findings suggest that PBT-2, acting as a metal protein attenuating compound, may be helpful in the prevention of AD or alleviation of ageing.

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Motor Cortex Excitability Changes in Mild Alzheimer's Disease Are Reversed by Donepezil

Cited by 6 publications

References 30 publications

Reproducibility of Single-Pulse, Paired-Pulse, and Intermittent Theta-Burst TMS Measures in Healthy Aging, Type-2 Diabetes, and Alzheimer’s Disease

Reproducibility of Single-Pulse, Paired-Pulse, and Intermittent Theta-Burst TMS Measures in Healthy Aging, Type-2 Diabetes, and Alzheimer’s Disease

Music Cued Exercises for People Living with Dementia:A Systematic Review

Possible role of metal ionophore against zinc induced cognitive dysfunction in d-galactose senescent mice

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