Motor cortex plasticity can indicate vulnerability to motor fluctuation and high L-DOPA need in drug-naïve Parkinson's disease

Kishore, Asha; James, Praveen; Krishnan, Syam; Yahia-Chérif, Lydia; Meunier, Sabine; Popa, Traian

doi:10.1016/j.parkreldis.2016.12.005

Cited by 15 publications

(16 citation statements)

References 30 publications

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“…The abnormal response to PAS in dyskinetic patients may be restored by inhibitory stimulation of the cerebellum (continuous theta burst stimulation [cTBS]) . Finally, it has been reported that early de novo PD patients have an abnormally enhanced response to PAS on the clinically less affected side and a smaller response on the clinically more affected side; but in a larger number of de novo PD patients it was found that patients and healthy individuals had similar proportions of responders (40%) and non‐responders to PAS …”

Section: Methodsmentioning

confidence: 99%

“…58 Finally, it has been reported that early de novo PD patients have an abnormally enhanced response to PAS on the clinically less affected side and a smaller response on the clinically more affected side 52 ; but in a larger number of de novo PD patients it was found that patients and healthy individuals had similar proportions of responders (40%) and non-responders to PAS. 59 Plasticity tested by intermittent theta burst stimulation (iTBS) and cTBS has been reported to be reduced in patients with PD, 60,61 but these data have not been confirmed elsewhere for iTBS. 62 Moreover, it has been shown that the response to TBS changes during the disease course, and it is strongly influenced by persistent treatment effects and the degree of dopaminergic denervation.…”

Section: Variability In Motor Cortex Plasticitymentioning

confidence: 99%

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The interindividual variability of transcranial magnetic stimulation effects: Implications for diagnostic use in movement disorders

et al. 2019

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Background A large number of methods have been described that use transcranial magnetic stimulation to probe the physiology of the human motor cortex. Since the 1990s, hundreds of papers have used them to investigate neurophysiological signatures of different types of movement disorders. However, in recent years there has been increasing recognition of the interindividual variability of these measures and a focus on estimating their reliability and reproducibility. Although this work has been carried out in healthy individuals, it is highly relevant to movement disorders because it may impact the validity of some accepted (“canonical”) neurophysiological biomarkers. The aim of this review is to reexamine the diagnostic usefulness of transcranial magnetic stimulation methods in movement disorders in the context of present knowledge of methodological variability. Methods We conducted a search of the PubMed database for research and review articles on transcranial magnetic stimulation and its diagnostic utility in movement disorders (specifically Parkinson's disease and atypical parkinsonism, dystonia, Tourette syndrome and other chronic tic disorders, Huntington's disease, and essential tremor). We highlighted contradictions in the literature and common misconceptions with the aim of providing a clearer picture of the reliability of these measures in differential diagnosis of movement disorders. Conclusion Although there is no doubt that these studies have provided useful insight into the pathophysiology of movement disorders, there is a clear disagreement among many studies that questions the validity of some of the so called “canonical” findings as diagnostic markers. However, useful findings remain and even those with higher variability can be used to support clinical diagnosis in selected cases. © 2019 International Parkinson and Movement Disorder Society

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Section: Methodsmentioning

confidence: 99%

Section: Variability In Motor Cortex Plasticitymentioning

confidence: 99%

The interindividual variability of transcranial magnetic stimulation effects: Implications for diagnostic use in movement disorders

et al. 2019

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“…Neurophysiological studies in humans using transcranial magnetic stimulation (TMS) have revealed changes in resting measures of excitability and plasticity in M1. There is enhanced corticospinal excitability and reduced M1 inhibition (Cantello et al, 2002;Currà et al, 2002;Lefaucheur et al, 2005;Berardelli et al, 2008;Bologna et al, 2016b), together with reduced long-term potentiation (LTP)-like plasticity in M1 (Morgante et al, 2006;Ueki et al, 2006;Schwingenschuh et al, 2010;Suppa et al, 2011;Kojovic et al, 2012 andKawashima et al, 2013;Kishore et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have reported a weak relationship between changes in plasticity and clinical motor scores, i.e. lower plasticity associated with more severe motor symptoms (Ueki et al, 2006;Kojovic et al, 2012 andKishore et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Neurophysiological correlates of bradykinesia in Parkinson’s disease

Bologna

Guerra

Paparella

et al. 2018

Brain

111

115

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Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson's disease. However, it is unclear whether there is any relationship between them and bradykinesia, one of the cardinal motor features of the condition. In the present study we aimed to investigate whether objective measures of bradykinesia in Parkinson's disease have any relationship with neurophysiological measures in primary motor cortex as assessed by means of transcranial magnetic stimulation techniques. Twenty-two patients with Parkinson's disease and 18 healthy subjects were enrolled. Objective measurements of repetitive finger tapping (amplitude, speed and decrement) were obtained using a motion analysis system. The excitability of primary motor cortex was assessed by recording the input/output curve of the motor-evoked potentials and using a conditioning-test paradigm for the assessment of short-interval intracortical inhibition and facilitation. Plasticity-like mechanisms in primary motor cortex were indexed according to the amplitude changes in motor-evoked potentials after the paired associative stimulation protocol. Patients were assessed in two sessions, i.e. OFF and ON medication. A canonical correlation analysis was used to test for relationships between the kinematic and neurophysiological variables. Patients with Parkinson's disease tapped more slowly and with smaller amplitude than normal, and displayed decrement as tapping progressed. They also had steeper input/output curves, reduced short-interval intracortical inhibition and a reduced response to the paired associative stimulation protocol. Within the patient group, bradykinesia features correlated with the slope of the input/output curve and the after-effects of the paired associative stimulation protocol. Although dopaminergic therapy improved movement kinematics as well as neurophysiological measures, there was no relationship between them. In conclusion, neurophysiological changes in primary motor cortex relate to bradykinesia in patients with Parkinson's disease, although other mechanisms sensitive to dopamine levels must also play a role.

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“…The basic response to PAS is known to be variable in the general population 18 – 20 . Following the previously validated approach to enhance the description accuracy of plastic phenomena 19 , 21 , we separated the subjects in responders and non-responders to PAS.…”

Section: Resultsmentioning

confidence: 99%

Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia

Popa

Hubsch

James

et al. 2018

Sci Rep

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The cerebellum can influence the responsiveness of the primary motor cortex (M1) to undergo spike timing-dependent plastic changes through a complex mechanism involving multiple relays in the cerebello-thalamo-cortical pathway. Previous TMS studies showed that cerebellar cortex excitation can block the increase in M1 excitability induced by a paired-associative stimulation (PAS), while cerebellar cortex inhibition would enhance it. Since cerebellum is known to be affected in many types of dystonia, this bidirectional modulation was assessed in 22 patients with cervical dystonia and 23 healthy controls. Exactly opposite effects were found in patients: cerebellar inhibition suppressed the effects of PAS, while cerebellar excitation enhanced them. Another experiment comparing healthy subjects maintaining the head straight with subjects maintaining the head turned as the patients found that turning the head is enough to invert the cerebellar modulation of M1 plasticity. A third control experiment in healthy subjects showed that proprioceptive perturbation of the sterno-cleido-mastoid muscle had the same effects as turning the head. We discuss these finding in the light of the recent model of a mesencephalic head integrator. We also suggest that abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions of the integrator in cervical dystonia.

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Motor cortex plasticity can indicate vulnerability to motor fluctuation and high L-DOPA need in drug-naïve Parkinson's disease

Cited by 15 publications

References 30 publications

The interindividual variability of transcranial magnetic stimulation effects: Implications for diagnostic use in movement disorders

The interindividual variability of transcranial magnetic stimulation effects: Implications for diagnostic use in movement disorders

Neurophysiological correlates of bradykinesia in Parkinson’s disease

Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia

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