Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders

Hirjak, Dušan; Meyer‐Lindenberg, Andreas; Fritze, Stefan; Sambataro, Fabio; Kubera, Katharina M.

doi:10.1016/j.neubiorev.2018.09.009

Cited by 52 publications

(25 citation statements)

References 412 publications

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“…The OFC is a key region that subserves a variety of highorder motor control processes, [61][62][63][64][65] and hence OFC alterations may contribute to many neuropsychiatric disorders and their typical behavioral symptoms. 5 SPG plays a crucial role in execution of skillful movements predominantly at the level of sensorimotor and visuospatial control. 5 Another region responsible for perception and object recognition is LOG, which functionally overlaps with a face-selective region, ie, the fusiform cortex.…”

Section: Morphological Differences Between Patients With and Without mentioning

confidence: 99%

“…5 SPG plays a crucial role in execution of skillful movements predominantly at the level of sensorimotor and visuospatial control. 5 Another region responsible for perception and object recognition is LOG, which functionally overlaps with a face-selective region, ie, the fusiform cortex. 5 Our data are in line with previous findings from functional MRI studies that have identified alterations in prefrontal (ie, OFC) and parietal (ie, SPG) regions of catatonic patients.…”

Section: Morphological Differences Between Patients With and Without mentioning

confidence: 99%

“…5 Another region responsible for perception and object recognition is LOG, which functionally overlaps with a face-selective region, ie, the fusiform cortex. 5 Our data are in line with previous findings from functional MRI studies that have identified alterations in prefrontal (ie, OFC) and parietal (ie, SPG) regions of catatonic patients. 31,36,66,67 Furthermore, our study endorses the dysfunction of the medial OFC, SPG, and LOG that can lead to the decoupling of motor control from the spatial integration of the body and face-selective perception.…”

Section: Morphological Differences Between Patients With and Without mentioning

confidence: 99%

“…1 Catatonic symptoms are frequently present in schizophrenia spectrum disorders (SSD), 2,3 affective and neurodevelopmental disorders, as well as in various medical conditions. [4][5][6] The clinical picture of catatonia includes motor phenomena (rigor, dyskinesia, festination, counteracting, posturing, catalepsy, etc. ), affective symptoms (aggression, anxiety, flat affect, affect incontinence, etc.…”

Section: Introductionmentioning

confidence: 99%

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Cortical Contributions to Distinct Symptom Dimensions of Catatonia

Hirjak

Kubera

Northoff

et al. 2019

Schizophrenia Bulletin

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Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural magnetic resonance imaging data at 3 T were obtained from 56 right-handed patients with SSD. Using FreeSurfer version 6.0, we calculated cortical thickness, area, and local gyrification index (LGI). Catatonic symptoms were examined on the Northoff catatonia rating scale (NCRS). Patients with catatonia (NCRS total score ≥3; n = 25) showed reduced surface area in the parietal and medial orbitofrontal gyrus and LGI in the temporal gyrus (P < .05, corrected for cluster-wise probability [CWP]) as well as hypergyrification in rostral cingulate and medial orbitofrontal gyrus when compared with patients without catatonia (n = 22; P < .05, corrected for CWP). Following a dimensional approach, a negative association between NCRS motor and behavior scores and cortical thickness in superior frontal, insular, and precentral cortex was found (34 patients with at least 1 motor and at least 1 other affective or behavioral symptom; P < .05, corrected for CWP). Positive associations were found between NCRS motor and behavior scores and surface area and LGI in superior frontal, posterior cingulate, precentral, and pericalcarine gyrus (P < .05, corrected for CWP). The data support the notion that cortical features of distinct evolutionary and genetic origin differently contribute to catatonia in SSD. Catatonia in SSD may be essentially driven by cortex variations in frontoparietal regions including regions implicated in the coordination and goal-orientation of behavior.

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Section: Morphological Differences Between Patients With and Without mentioning

confidence: 99%

Section: Morphological Differences Between Patients With and Without mentioning

confidence: 99%

Section: Morphological Differences Between Patients With and Without mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cortical Contributions to Distinct Symptom Dimensions of Catatonia

Hirjak

Kubera

Northoff

et al. 2019

Schizophrenia Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, a meta-analysis of euthymic individuals with bipolar disorder revealed psychomotor slowing in this population, though medication confounds complicated the interpretation of these results [20] (see also Correa-Ghisays et al [21]). Neurological soft signs have been reported in bipolar disorder (see Hirjak et al [22] and Peralta and Cuesta [23] for reviews), including in currently psychotic individuals [24,25], individuals with no history of psychosis [26], and euthymic individuals [27]. Bolbecker et al [28] reported balance impairments in euthymic individuals with bipolar disorder during a static task, while Kang et al [29] reported impaired balance in depressed but not euthymic individuals with bipolar disorder during a dynamic task.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction

et al. 2019

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Background: A number of motor abnormalities have been reported in psychotic disorders, including dyskinesia and psychomotor slowing. There is also evidence for many of the same motor abnormalities in biological first-degree relatives and accruing evidence for motor abnormalities in bipolar disorder. In addition to motor dysfunction, there are also shared symptom domains amongst these populations. Objectives: We explored the associations of (1) current and lifetime psychosis and mood symptom domains and (2) domains of psychosis proneness with various domains of motor function in a transdiagnostic sample (n = 149). Method: Individuals with schizophrenia, schizoaffective disorder, or bipolar disorder, biological first-degree relatives of individuals with a psychotic disorder, and controls completed measures of psychomotor speed and movement fluidity, and neural activity related to motor preparation (stimulus-locked lateralized readiness potential, S-LRP) and execution (response-locked LRP) was assessed using EEG. All participants completed the Brief Psychiatric Rating Scale; patients were additionally assessed for lifetime psychosis and mood episode symptoms, and relatives and controls completed the Chapman psychosis proneness scales. Results: Multiple regression revealed levels of current negative symptoms and mania were significantly positively associated with psychomotor slowing even after accounting for current antipsychotic medication dosage and duration of illness. S-LRP onset latency was significantly positively associated with magical ideation. Conclusion: Domains of motor function are associated with various mood and psychosis symptom domains in a transdiagnostic sample, which may provide insight into brain abnormalities relevant to the expression of symptoms across disorders.

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Motor Impairment Increases in Children With Autism Spectrum Disorder as a Function of Social Communication, Cognitive and Functional Impairment, Repetitive Behavior Severity, and Comorbid Diagnoses: A SPARK Study Report

2020

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Eighty-seven percent of a large sample of children with autism spectrum disorder (ASD) are at risk for motor impairment (Bhat, Physical Therapy, 2020, 100, 633-644). In spite of the high prevalence for motor impairment in children with ASD, it is not considered among the diagnostic criteria or specifiers within DSM-V. In this article, we analyzed the SPARK study dataset (n = 13,887) to examine associations between risk for motor impairment using the Developmental Coordination Disorder-Questionnaire (DCD-Q), social communication impairment using the Social Communication Questionnaire (SCQ), repetitive behavior severity using the Repetitive Behaviors Scale-Revised (RBS-R), and parent-reported categories of cognitive, functional, and language impairments. Upon including children with ASD with cognitive impairments, 88.2% of the SPARK sample was at risk for motor impairment. The relative risk ratio for motor impairment in children with ASD was 22.2 times greater compared to the general population and that risk further increased up to 6.2 with increasing social communication (5.7), functional (6.2), cognitive (3.8), and language (1.6) impairments as well as repetitive behavior severity (5.0). Additionally, the magnitude of risk for motor impairment (fine-and gross-motor) increased with increasing severity of all impairment types with medium to large effects. These findings highlight the multisystem nature of ASD, the need to recognize motor impairments as one of the diagnostic criteria or specifiers for ASD, and the need for appropriate motor screening and assessment of children with ASD. Interventions must address not only the social communication and cognitive/behavioral challenges of children with ASD but also their motor function and participation.

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Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders

Cited by 52 publications

References 412 publications

Cortical Contributions to Distinct Symptom Dimensions of Catatonia

Cortical Contributions to Distinct Symptom Dimensions of Catatonia

Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction

Motor Impairment Increases in Children With Autism Spectrum Disorder as a Function of Social Communication, Cognitive and Functional Impairment, Repetitive Behavior Severity, and Comorbid Diagnoses: A SPARK Study Report

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