Motor Events during Healthy Sleep: A Quantitative Polysomnographic Study

Frauscher, Birgit; Gabelia, David; Mitterling, Thomas; Biermayr, Marlene; Bregler, Deborah; Ehrmann, Laura; Ulmer, Hanno; Högl, Birgit

doi:10.5665/sleep.3586

Cited by 90 publications

(93 citation statements)

References 43 publications

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“…The patients we report had "any" EMG activity index values ranging from 13.7% to 37.6% utilizing the conventional 3-second mini-epoch scoring. Only patient 3 had an "any" EMG activity index that exceeded the cutoff for both RBD and the 95 th percentile of healthy normal reported by the SINBAR group and Frauscher et al 17,19 The nature of our report limits our ability to propose an "any" EMG activity index cutoff value for TSD. However, as the majority of our patients had normal values for their "any" EMG activity index, a normal index does not necessarily exclude TSD.…”

Section: Discussionmentioning

confidence: 46%

Trauma Associated Sleep Disorder: A Proposed Parasomnia Encompassing Disruptive Nocturnal Behaviors, Nightmares, and REM without Atonia in Trauma Survivors

Mysliwiec¹,

O’Reilly

Polchinski

et al. 2014

Journal of Clinical Sleep Medicine

101

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S C I E N T I F I C I N V E S T I G A T I O N SD isruptive nocturnal behaviors (DNB) consisting of excessive movements, autonomic hyperarousal, abnormal vocalizations and complex motor behaviors, and nightmares which are replays of traumatic experiences are frequently reported sleep disturbances in combat veterans and trauma survivors with and without posttraumatic stress disorder (PTSD).1-6 Despite their frequent occurrence, there is no established diagnosis that accurately encompasses these sleep disturbances. Lack of diagnostic criteria is likely secondary to the discrepancy between frequent self-reported DNB and the rare occurrence of DNB in laboratory settings. 1,7,8 Thus, the exact nature of DNB in terms of their sleep stage, electromyographic (EMG) characteristics, and physiologic parameters are relatively unknown.Nightmare disorder is reported in up to 80% of patients with PTSD.9 This diagnosis does not acknowledge the presence of the DNB that trauma survivors frequently report.2,4,9 Secondary REM behavior disorder is reported to occur in patients with PTSD when REM without atonia (RWA) is present on a polysomnogram (PSG) and dream enactment behaviors are reported or are present on PSG 4,10 ; however, the onset of DNB and nightmares after an inciting traumatic event and the autonomic hyperactivity reported with trauma associated sleep disturbances are clinical and physiologic abnormalities that are not associated with REM behavior disorder (RBD).

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Section: Discussionmentioning

confidence: 46%

Trauma Associated Sleep Disorder: A Proposed Parasomnia Encompassing Disruptive Nocturnal Behaviors, Nightmares, and REM without Atonia in Trauma Survivors

Mysliwiec¹,

O’Reilly

Polchinski

et al. 2014

Journal of Clinical Sleep Medicine

101

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“…The fact that hypnic myoclonus displays the characteristics of fasciculation potentials has been noted also by Montagna et al (1988). A few studies have reported electrophysiologically confirmed benign fasciculation syndrome in the group of EFM patients (Frauscher et al, 2014;Raccagni et al, 2016).…”

Section: Neurophysiologymentioning

confidence: 89%

“…Frauscher et al (2014) reported non-excessive FM in every single subject in the group of 100 healthy subjects, whereas 9% met the criteria for the excessive form.…”

Section: )mentioning

confidence: 99%

Excessive Fragmentary Myoclonus: What Do We Know?

Nepožitek

Šonka

2017

Prague Med. Rep.

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Abstract:Excessive fragmentary myoclonus (EFM) is a polysomnographic finding registered by the surface electromyography (EMG) and characterized as a result of the muscle activity consisting of sudden, isolated, arrhythmic, asynchronous and asymmetric brief twitches. The EMG potentials are defined by the exact criteria in The International Classification of the Sleep Disorders, 3 rd edition and they appear with high intensity in all sleep stages. Clinical significance of EFM is unclear. It was observed in combination with other diseases and features such as obstructive and central sleep apnea, narcolepsy, periodic limb movements, insomnia, neurodegenerative disorders and peripheral nerve dysfunction. Relation to such wide range of diseases supports the opinion that EFM is nor a specific sleep disorder nor a specific polysomnographic sign. The option that EFM is a normal variant has also not been ruled out so far.

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“…All participating volunteers underwent a two-step screening process (telephone interview, personal investigation by a physician trained in sleep medicine) to exclude a relevant sleep, neurological, psychiatric or internal comorbidity as well as any use of central nervous system medication (for detailed methodology see [16]). …”

Section: Methodsmentioning

confidence: 99%

Do periodic arm movements during sleep exist in healthy subjects? A polysomnographic study

et al. 2014

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BackgroundDespite several polysomnographic studies on periodic leg movements (PLM) in healthy sleep, data on the prevalence and characteristics of periodic arm movements (PAM) in normal subjects are lacking. We aimed to investigate PAM and their association with PLM during wakefulness and sleep in healthy subjects.MethodsNinety-one participants underwent video-polysomnography according to American Academy of Sleep Medicine 2007 criteria. In addition to standard electromyographic registration, data for both flexor digitorum superficialis muscles were recorded.ResultsSixty-two subjects (68.1%) had a PAM index during wakefulness >5/h (median PAM index during wakefulness, 8.8/h; range, 0–77). Seven subjects (7.7%) had a PAM index >5/h during sleep (median PAM index during sleep, 0.7/h; range, 0–47.4). In 14% of cases, PAM during wakefulness were coincident with PLM during wakefulness. During sleep, this coincidence was not evident. The correlation between PAM and PLM was weak to moderate (during wakefulness: Spearman's ρ = 0.576, P < 0.001; during sleep: Spearman's ρ = 0.222, P = 0.036).ConclusionIn healthy subjects, PAM occur predominantly during wakefulness with no apparent true periodicity. In contrast to classical PLM, some PAM may not present a true periodic phenomenon, but rather random voluntary movements meeting the wide range of periodicity criteria for PLM.

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Motor Events during Healthy Sleep: A Quantitative Polysomnographic Study

Cited by 90 publications

References 43 publications

Trauma Associated Sleep Disorder: A Proposed Parasomnia Encompassing Disruptive Nocturnal Behaviors, Nightmares, and REM without Atonia in Trauma Survivors

Trauma Associated Sleep Disorder: A Proposed Parasomnia Encompassing Disruptive Nocturnal Behaviors, Nightmares, and REM without Atonia in Trauma Survivors

Excessive Fragmentary Myoclonus: What Do We Know?

Do periodic arm movements during sleep exist in healthy subjects? A polysomnographic study

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