Motor fatigability in persons with multiple sclerosis: Relation between different upper limb muscles, and with fatigue and the perceived use of the arm in daily life

Severijns, Deborah; Geel, Fanny Van; Feys, Peter

doi:10.1016/j.msard.2017.11.016

Cited by 14 publications

(21 citation statements)

References 32 publications

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“…Consequently, neuromuscular fatigability is highly variable between individuals but could be interrelated between different muscle groups. Although this is coherent with results from a previous study (Severijns et al., 2018), some other studies are inconsistent (White et al., 2013). One reason for these discrepancies might be that the studies used relatively short fatiguing exercises (36 and 30 s of accumulated contraction time, respectively, compared with 240 s in the present study).…”

Section: Discussionsupporting

confidence: 90%

“…PFs are less fatigable than finger flexors (FFs)], very few studies have investigated the possible relationships of fatigability between different muscles, and the reported results are inconsistent. Although Severijns, Van Geel, and Feys (2018) showed a moderate correlation between the fatigue index of elbow flexors and shoulder abductors, other studies revealed no correlation between the fatigue index of knee extensors and FFs (White, Dixon, Samuel, & Stokes, 2013) or of finger abductors, FFs and elbow flexors (Severijns et al., 2018). As a result of the different methodologies used, these studies offer no definitive understanding regarding the consistency of fatigability patterns across different muscles.…”

Section: Introductionmentioning

confidence: 97%

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Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

Chartogne

Rahmani

Nicolon

et al. 2020

Experimental Physiology

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Neuromuscular fatigability is commonly attributed to central and peripheral origins. However, there is strong evidence of interactions between these two mechanisms. According to the idea that peripheral fatigability might be centrally regulated, one can hypothesize that neuromuscular fatigability would be correlated between different muscle groups at the individual level. Thirty-two healthy participants (16 women and 16 men) completed two 5 min fatiguing exercises [60 isometric maximal voluntary contractions (MVCs)] with finger flexors (FFs) and ankle plantar flexors (PFs) in two randomized sessions. Neuromuscular testing was conducted before, during (every six MVCs) and directly after the fatigue procedure. The force asymptote (F A) was calculated as the asymptote of the forcetime relationship. Changes (post-vs. pre-fatigue) in the exercise-evoked force (ΔDb 100), voluntary activation (ΔVA) and central activation ratio (∆CAR) were also investigated.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 97%

Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

Chartogne

Rahmani

Nicolon

et al. 2020

Experimental Physiology

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“…However, in relation to walking, the muscle strength seems to be a stronger predictor indicating a hierarchical order, with muscle strength being the primary prerequisite for walking and muscle endurance (fatigability) being secondary. This way of thinking is in line with results from the study by Severijns et al 38 showing that upper-limb function is reliant on maximal finger strength (eg, ability to lift an object) and, second, on elbow flexor endurance (eg, ability to hold on to the object).…”

Section: Fatigability and Walkingsupporting

confidence: 88%

“…However, when adjusting for muscle strength, these studies did find an association between the level of fatigability in isolated hand models and perception of fatigue. Likewise, a study by Severijns et al 38 did find an association between their 30-s static FI in 4 different upper-limb muscles and perception of fatigue. These findings are in contrast with the findings of the present study but may be caused by differences in blood flow restrictions during different types of sustained isometric contractions (ie, intensity of contraction and muscles involved) 39 ; also, the involvement of the large lower-extremity musculature in the present study leads to more pronounced peripheral fatigability.…”

Section: Fatigability and Perception Of Fatigue Impactmentioning

confidence: 82%

A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis

Taul-Madsen

Dalgas

Kjølhede

et al. 2020

Neurorehabil Neural Repair

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Background. Fatigue is one of the most frequent symptoms in persons with multiple sclerosis (MS). Distinction is made between subjective perceptions of fatigue and objective measures of fatigability. Fatigability can be measured by different protocols. Yet no studies have compared isometric and concentric contraction protocols of the lower extremities head-to-head. Therefore, the purpose of the present study was to (1) compare 2 such protocols head-to-head and (2) to investigate the association between fatigability evoked by the 2 protocols and measures of fatigue and walking. Methods. A total of 45 patients with MS had their walking capacity measured objectively by the 6-minute walk test (6MWT) and subjectively by the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Fatigue was measured by the Modified Fatigue Impact Scale (MFIS) and fatigability by 2 knee extension protocols: sustained isometric and concentric. Results. The sustained isometric protocol induced a higher degree of fatigability than the concentric protocol ( P < .01). Regression analyses revealed that sustained isometric fatigability was not associated with either measures of fatigue or walking (all r2 = 0.00; P = .85-.99), whereas the concentric protocol was significantly associated with fatigue ( r2 = 0.20; P < .01), 6MWT ( r2 = 0.09; P < .05), and MSWS-12 ( r2 = 0.16; P < .01). Furthermore, after adjusting for maximal strength and sex, concentric fatigability remained a strong and significant predictor of fatigue (β = 0.49) and walking (6MWT: β = −0.26; MSWS: β = 0.37). Conclusion. This study provides the first evidence that a lower-extremity concentric fatigability protocol provides superior reflection of both fatigue and walking when compared with a sustained isometric protocol. We suggest that concentric protocols should be the focus of future studies investigating fatigability.

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“…A major challenge in objectively measuring physical fatigue is the lack of standardized tools . In terms of muscle fatigue, both the duration of contraction and indices calculated based on deterioration of strength over time have been demonstrated as useful tools . Previous studies have shown decreased endurance time and voluntary muscle recruitment in fatigued cancer patients .…”

Section: Discussionmentioning

confidence: 99%

Cognitive and motor aspects of cancer‐related fatigue

et al. 2019

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Background Cancer‐related fatigue (CRF) is a debilitating symptom frequently reported by patients during and after treatment for cancer. CRF is a multidimensional experience and is often solely assessed by self‐report measures. The goal of the study is to examine the physical and cognitive aspects of self‐reported CRF using a cognitive function test and a physical fatigue index in order to provide objective measures that can characterize the CRF phenotype. Methods A total of 59 subjects with nonmetastatic prostate cancer receiving external beam radiation therapy were included in the study. Fatigue was measured using the Functional Assessment of Cancer Therapy‐Fatigue (FACT‐F) questionnaire. Cognitive characteristics of CRF was measured using the Stroop Color‐Word Interference computerized test and the motor aspect of fatigue was measured using the static fatigue test using a handgrip dynamometer. Findings Functional Assessment of Cancer Therapy‐Fatigue scores significantly correlated with the Stroop Interference score, but not performance accuracy in all test conditions. Fatigued subjects exhibited a more rapid decline to 50% of maximal strength and increased static fatigue index in the handgrip test, whereas maximal grip strength was not affected. Conclusions The results suggest that CRF exhibits both cognitive and physical characteristics. Subjective fatigue was associated with increased time required to overcome cognitive interference, but not cognitive performance accuracy. Fatigued patients exhibited decreased physical endurance and the ability to sustain maximal strength over time. These objective measures may serve as valuable tools for clinicians to detect cognitive and physical impairment associated with CRF.

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Motor fatigability in persons with multiple sclerosis: Relation between different upper limb muscles, and with fatigue and the perceived use of the arm in daily life

Cited by 14 publications

References 32 publications

Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

A Head-to-Head Comparison of an Isometric and a Concentric Fatigability Protocol and the Association With Fatigue and Walking in Persons With Multiple Sclerosis

Cognitive and motor aspects of cancer‐related fatigue

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