Motor map reliability and aging: a TMS/fMRI study

McGregor, Keith M.; Carpenter, Haley; Kleim, Erin; Sudhyadhom, Atchar; White, Keith D.; Butler, Andrew; Kleim, Jeffrey A.; Crosson, Bruce

doi:10.1007/s00221-012-3070-3

Cited by 38 publications

(42 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More specifically, the high reliability, captured by the intraclass correlation (ICC), of the RMT and mean map MEP amplitude confirmed previous findings following shorter observation periods [49–53]. Former findings on the consistency of the CoG were more variable [15, 48, 51, 53] than the high reliability in the present study for observation periods of up to 1.5 years.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Neuromuscular Plasticity: Disentangling Stable and Variable Motor Maps in the Human Sensorimotor Cortex

Kraus

Gharabaghi

2016

Neural Plasticity

View full text Add to dashboard Cite

Motor maps acquired with transcranial magnetic stimulation (TMS) are evolving as a biomarker for monitoring disease progression or the effects of therapeutic interventions. High test-retest reliability of this technique for long observation periods is therefore required to differentiate daily or weekly fluctuations from stable plastic reorganization of corticospinal connectivity. In this study, a novel projection, interpolation, and coregistration technique, which considers the individual gyral anatomy, was applied in healthy subjects for biweekly acquired TMS motor maps over a period of twelve weeks. The intraclass correlation coefficient revealed long-term reliability of motor maps with relevant interhemispheric differences. The sensorimotor cortex and nonprimary motor areas of the dominant hemisphere showed more extended and more stable corticospinal connectivity. Long-term correlations of the MEP amplitudes at each stimulation site revealed mosaic-like clusters of consistent corticospinal excitability. The resting motor threshold, centre of gravity, and mean MEPs across all TMS sites, as highly reliable cortical map parameters, could be disentangled from more variable parameters such as MEP area and volume. Cortical TMS motor maps provide high test-retest reliability for long-term monitoring when analyzed with refined techniques. They may guide restorative interventions which target dormant corticospinal connectivity for neurorehabilitation.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Former findings on the consistency of the CoG were more variable [15, 48, 51, 53] than the high reliability in the present study for observation periods of up to 1.5 years.…”

Section: Discussioncontrasting

confidence: 54%

Neuromuscular Plasticity: Disentangling Stable and Variable Motor Maps in the Human Sensorimotor Cortex

Kraus

Gharabaghi

2016

Neural Plasticity

View full text Add to dashboard Cite

show abstract

“…Using this approach, intersession reliability of motor-related activation in this study was found to be comparable to previously published results for both spatial overlap and ICC measures (Bennett and Miller, 2010; Gountouna et al, 2010; Havel et al, 2006; Kong et al, 2007; McGregor et al, 2012; Yoo et al, 2005). This supports the validity and appropriateness of the analytical approach used in this study to assess intersession reliability of pain-related fMRI activation.…”

Section: Discussionsupporting

confidence: 89%

“…High test-retest reliability of fMRI responses across two or more sessions has been reported for a wide variety of tasks, including motor, auditory detection, language, learning, and memory (Atri et al, 2011; Bennett and Miller, 2010; Cacares et al, 2009; Chen et al, 2007; Fliessbach et al, 2010; Freyer et al, 2009; Gorgolewski et al, 2013; Gountouna et al, 2010; Havel et al, 2006; Kiehl and Liddle, 2003; Maitra et al, 2002; McGregor et al, 2012; Yoo et al, 2005). However, poor test–retest reliability of fMRI responses has been found for other tasks such as mouth movements (Havel et al, 2006), reward (Fliessbach et al, 2010), and spatial attention (Gorgolewski et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

Intersession reliability of fMRI activation for heat pain and motor tasks

Quiton

Keaser

Zhuo

et al. 2014

NeuroImage: Clinical

View full text Add to dashboard Cite

As the practice of conducting longitudinal fMRI studies to assess mechanisms of pain-reducing interventions becomes more common, there is a great need to assess the test–retest reliability of the pain-related BOLD fMRI signal across repeated sessions. This study quantitatively evaluated the reliability of heat pain-related BOLD fMRI brain responses in healthy volunteers across 3 sessions conducted on separate days using two measures: (1) intraclass correlation coefficients (ICC) calculated based on signal amplitude and (2) spatial overlap. The ICC analysis of pain-related BOLD fMRI responses showed fair-to-moderate intersession reliability in brain areas regarded as part of the cortical pain network. Areas with the highest intersession reliability based on the ICC analysis included the anterior midcingulate cortex, anterior insula, and second somatosensory cortex. Areas with the lowest intersession reliability based on the ICC analysis also showed low spatial reliability; these regions included pregenual anterior cingulate cortex, primary somatosensory cortex, and posterior insula. Thus, this study found regional differences in pain-related BOLD fMRI response reliability, which may provide useful information to guide longitudinal pain studies. A simple motor task (finger-thumb opposition) was performed by the same subjects in the same sessions as the painful heat stimuli were delivered. Intersession reliability of fMRI activation in cortical motor areas was comparable to previously published findings for both spatial overlap and ICC measures, providing support for the validity of the analytical approach used to assess intersession reliability of pain-related fMRI activation. A secondary finding of this study is that the use of standard ICC alone as a measure of reliability may not be sufficient, as the underlying variance structure of an fMRI dataset can result in inappropriately high ICC values; a method to eliminate these false positive results was used in this study and is recommended for future studies of test–retest reliability.

show abstract

“…Previous studies have reported relationships between fMRI and TMS in healthy subjects. It has been shown that fMRI activation is positively related to corticomotor output maps, 38 while BOLD fMRI signal intensity of activation is related to TCI. 39, 40 With chronic stroke patients, it has been shown that reduced fMRI laterality to the ipsilesional hemisphere relates to smaller motor evoked potentials.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Inter-Hemispheric Imbalance Using Imaging and Noninvasive Brain Stimulation in Patients With Chronic Stroke

Cunningham

Machado

Janini

et al. 2015

Archives of Physical Medicine and Rehabilitation

View full text Add to dashboard Cite

OBJECTIVE To determine how inter-hemispheric balance in stroke, measured using transcranial magnetic stimulation (TMS), relates to balance defined using neuroimaging (functional magnetic resonance (fMRI) and diffusion tensor imaging (DTI)), and how these metrics of balance are associated with clinical measures of upper limb function and disability. DESIGN Cross-Sectional SETTING Clinical Research Laboratory PARTICIPANTS Ten chronic stroke patients (63±9 years) in a population based sample with unilateral upper-limb paresis. INTERVENTION Not applicable MAIN OUTCOME MEASURES Inter-hemispheric balance was measured with TMS, fMRI and DTI. TMS defined inter-hemispheric differences in recruitment of corticospinal output, the size of the corticomotor output maps and the degree of mutual transcallosal inhibition they exerted upon one another. fMRI studied whether cortical activation during the movement of the paretic hand was lateralized to the ipsilesional or to the contralesional primary motor (M1), premotor (PMC) and supplementary motor cortices (SMA). DTI was used to define inter-hemispheric differences in the integrity of the corticospinal tracts projecting from M1. Clinical outcomes tested function (upper-extremity Fugl-Meyer (UEFM) and the perceived disability in the use of the paretic hand [Motor Activity Log (MAL)]. RESULTS Inter-hemispheric balance assessed with TMS relates differently to fMRI and DTI. Patients with high fMRI lateralization to the ipsilesional hemisphere possessed stronger ipsilesional corticomotor output maps [M1 (r=.831, p=.006), PMC (r=.797, p=.01)], and better balance of mutual transcallosal inhibition (r=.810, p=.015). Conversely, we have found that patients with less integrity of the corticospinal tracts in the ipsilesional hemisphere show greater corticospinal output of homologous tracts in the contralesional hemisphere (r=.850, p=.004). However, neither an imbalance in their integrity nor an imbalance of their output relates to transcallosal inhibition. Clinically, while patients with less integrity of corticospinal tracts from the ipsilesional hemisphere showed worse impairments (UEFM) (r = −.768, p=.016), those with low fMRI lateralization to the ipsilesional hemisphere had greater perception of disability (MAL) [M1 (r=.883, p=.006), PMC (r=.817, p=.007) and SMA (r=.633, p=.062). CONCLUSIONS In patients with chronic motor deficits of the upper limb, fMRI may serve to mark perceived disability as well as transcallosal influence between hemispheres. DTI-based integrity of corticospinal tracts, however, may be useful in categorizing the range of functional impairments of the upper-limb. Further, in patients with extensive corticospinal damage, DTI may help infer the role of the contralesional hemisphere in recovery.

show abstract

Motor map reliability and aging: a TMS/fMRI study

Cited by 38 publications

References 47 publications

Neuromuscular Plasticity: Disentangling Stable and Variable Motor Maps in the Human Sensorimotor Cortex

Neuromuscular Plasticity: Disentangling Stable and Variable Motor Maps in the Human Sensorimotor Cortex

Intersession reliability of fMRI activation for heat pain and motor tasks

Assessment of Inter-Hemispheric Imbalance Using Imaging and Noninvasive Brain Stimulation in Patients With Chronic Stroke

Contact Info

Product

Resources

About