Motor Responses to GABA-ergic Interference in the Rat Entopeduncular Nucleus in Relation to Rotation Mechanisms

McKenzie, Jo; Shafton, Anthony D; Stewart, Carmel

doi:10.1007/978-1-4684-5347-8_22

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The evolution of this rotational behaviour was equivalent to that observed in animals that received only STN kainic acid lesion. This rotational behaviour has been observed previously (Burbaud et al, 1995;Murer et al, 1995) and was also observed in a study during which injection of muscimol into the substantia nigra pars reticulata induced ipsilateral turning (McKenzie et al, 1987). In the present study, apomorphine-induced ipsilateral turning can be explained by inhibition of the substantia nigra pars reticulata by the inhibitory direct striatonigral pathway which is still effective.…”

Section: Discussionsupporting

confidence: 92%

Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies

Piallat

Benazzouz

Benabid

1996

Eur J of Neuroscience

221

129

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Several studies have shown that antagonists of N-methyl-D-aspartate receptors provide protection of the dopaminergic nigrostriatal pathway in animal models of Parkinson's disease. Since the substantia nigra compacta receives a moderate glutamatergic innervation from the subthalamic nucleus, we tried to determine whether subthalamic nucleus lesion could prevent the toxicity of the selective dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA). Experiments were carried out on four groups of rats. Group 1 (n = 10) received a unilateral injection of 6-hydroxydopamine in the striatum and group 2 (n = 10) received kainic acid in the subthalamic nucleus. Group 3 (n = 10) received an injection of kainic acid in the subthalamic nucleus and 1 week later an injection of 6-OHDA in the striatum. Group 4 (n = 5) received the same treatment but kainic acid was replaced by saline. Apomorphine induced an ipsilateral rotation in rats of groups 2 and 3 and a contralateral rotation in rats of groups 1 and 4. The number of tyrosine hydroxylase-immunoreactive cells in the pars compacta of the substantia nigra was not significantly decreased on the side ipsilateral to 6-OHDA striatal injection in rats of groups 1 and 4. These results show that subthalamic nucleus lesion provides neuroprotection of the dopaminergic nigrostriatal pathway against 6-OHDA toxicity and opens a new way for slowing or stopping the progression of Parkinson's disease.

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Section: Discussionsupporting

confidence: 92%

Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies

Piallat

Benazzouz

Benabid

1996

Eur J of Neuroscience

221

129

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“…It is well known that in rats with degeneration of the nigrostriatal pathway after 6-OHDA injection into the SNc or into the striatum, apomorphine treatment induced contralateral rotational behavior (Ungerstedt and Arbuthnott, 1970;Burbaud et al, 1995;Piallat et al, 1996). Several studies reported that this behavior is a consequence of the postsynaptic supersensitivity of dopamine receptors in the striatum (Ungerstedt, 1971;DiChiara et al, 1978;McKenzie et al, 1987). According to these findings, 6-OHDA injection into the STN, inducing only a partial lesion of SNc cells, should be insufficient to cause behavioral changes.…”

Section: Behaviormentioning

confidence: 99%

Intrasubthalamic injection of 6‐hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the rat

Bouali‐Benazzouz

Gao

et al. 2001

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The subthalamic nucleus (STN) receives dopaminergic projections from the substantia nigra pars compacta (SNc). To investigate the role of direct and indirect dopaminergic influences on STN neurons, the spontaneous activity was studied in four groups of animals: normal rats, rats with intrasubthalamic or intranigral injection of 6-hydroxydopamine (6-OHDA), and sham STN injection rats by using extracellular recordings 4 weeks postsurgery. After intrasubthalamic injection of 6-OHDA, the mean firing rate significantly decreased (7.29 +/- 0.39 spikes/sec, P < 0.01 vs. 11.13 +/- 0.59 spikes/sec in normal or 11.26 +/- 0.57 spikes/sec in sham group), and the percentage of STN neurons discharging regularly decreased significantly (81%, P < 0.05 vs. 90% in normal group or P < 0.01 vs. 92% in sham group) and that of bursty cells increased (19%, P < 0.05 vs. 10%; in normal group or P < 0.01 vs. 8% in sham group). In the group of rats with SNc lesion, the firing rate of subthalamic neurons did not show a significant difference (11.61 +/- 0.81 spikes/sec) compared with normal group. However, the firing pattern was dramatically changed: 74% of cells exhibited bursty pattern and only 26% of cells discharged regularly or slightly irregularly. Immunohistochemical results showed that intrasubthalamic injection of 6-OHDA induced a marked degeneration of dopaminergic cells in the lateral part of the ipsilateral SNc, whereas 6-OHDA injection into the SNc induced a total in situ lesion of dopamine cells. These results suggest that the SNc exerts an excitatory influence on STN neurons and that the loss of this dopaminergic projection could, at least partially, account for the changes in the firing pattern of STN neurons in the 6-OHDA rat model of parkinsonism.

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Movement disorders induced by gamma-aminobutyric agonist and antagonist injections into the internal globus pallidus and substantia nigra pars reticulata of the monkey

et al. 1998

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Motor Responses to GABA-ergic Interference in the Rat Entopeduncular Nucleus in Relation to Rotation Mechanisms

Cited by 3 publications

References 7 publications

Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies

Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies

Intrasubthalamic injection of 6‐hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the rat

Movement disorders induced by gamma-aminobutyric agonist and antagonist injections into the internal globus pallidus and substantia nigra pars reticulata of the monkey

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