Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men

McNeil, Chris J.; Doherty, Timothy J.; Stashuk, Daniel W.; Rice, Charles L.

doi:10.1002/mus.20276

Cited by 279 publications

(300 citation statements)

References 42 publications

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“…Sarcopenia is characterized by progressive denervation with loss of motor units (McNeil et al, 2005). Since successful muscle regeneration is strictly dependent on the appropriate crosstalk between newborn fibers and motoneurons connected to immature regenerating muscle, we analyzed whether the neuronal recruitment pathway was involved in satellite cells derived from the elderly.…”

Section: Discussionmentioning

confidence: 99%

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Pietrangelo¹,

Puglielli²,

Mancinelli³

et al. 2009

Experimental Gerontology

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ular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Experimental Gerontology, Elsevier, 2009, 44 (8) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT AbstractSarcopenia is the age-related loss of muscle mass, strength and function. Human muscle proteins are synthesized at a slower rate in the elderly than in young adults, leading to atrophy and muscle mass loss with a decline in the functional capability. Additionally, aging is accompanied by a decrease in the ability of muscle tissue to regenerate following injury or overuse due to the impairment of intervening satellite cells, in which we previously reported oxidative damage evidences. The aim of the present study was to determine the effects of aging on myoblasts and myotubes obtained from human skeletal muscle, and characterize the transcriptional profile as molecular expression patterns in relation to age-dependent modifications in their regenerative capacity. Our data show that the failure to differentiate does not depend on reduced myogenic cell number, but difficulty to complete the differentiation program. Data reported here suggested the following findings: i) oxidative damage accumulation in molecular substrates, probably due to impaired antioxidant activity and insufficient repair capability, ii) limited capability of elderly myoblasts to execute a complete differentiation program; restricted fusion, possibly due to altered cytoskeleton turnover and extracellular matrix degradation, and iii) activation of atrophy mechanism by activation of a specific FOXO-dependent program.

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Section: Discussionmentioning

confidence: 99%

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Pietrangelo¹,

Puglielli²,

Mancinelli³

et al. 2009

Experimental Gerontology

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“…Not all motor units are functional and so the number of motor units measured by functional tests may be less than the total number of motor units that could be measured by anatomic methods. The number of motor units appears to decline with age, and may vary greatly among people [1,[3][4][5].…”

Section: Anatomy Of Motor Unitsmentioning

confidence: 99%

Assessment of Motor Units in Neuromuscular Disease

Henderson

McCombe

2017

Neurotherapeutics

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“…11 Additionally, as EMG of abductor hallucis and extensor digitorum brevis was not easily elicited in SCI patients, 14 the TA muscle was thus selected for test in this study.…”

Section: Mune Of Ta By Ampsmentioning

confidence: 99%

“…To our knowledge, there were only two MUNE study 10,11 of the TA muscle performed without SCI. In addition, the MUNE values of muscles distal to the site of injury in two non-longitudinal MUNE studies of SCI patients were different from each other.…”

Section: Introductionmentioning

confidence: 99%

Motor unit number estimation of the tibialis anterior muscle in spinal cord injury

Zhang

et al. 2008

Spinal Cord

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Methods: Motor unit number estimation (MUNE) in 45 control subjects (35 young subjects with an average age of 36 years, and 10 elderly subjects with an average age of 65 years) was performed by using adapted multiple point stimulation method (AMPS). Twenty patients with SCI (10 subacute patients with an average age of 39 years, and 10 chronic patients with an average age of 34 years) were also examined for three times in 3 months with the same method. Results: The mean MUNE value of the TA muscle was 188±20 in the control group, and 40±33 in subacute SCI patients (Po0.01 vs young controls). A continuous increase in the MUNE value was observed in subacute SCI patients during the later follow-up period. In the chronic SCI group, the mean MUNE value was173 ± 29 which was similar to that of young control group. Conclusions: AMPS could be a useful procedure for quantifying changes of MUNE values after SCI. Changes in functional motor unit number may occur distal to the site of lesion in SCI patients. These phenomena may be caused by neuronal plasticity in motor units, reversible transsynaptic degeneration and/or local functional depression. Owing to the limited sample size and a wide age range of subjects recruited in this study, future study are warranted for revealing detailed changes of MUNE parameters after SCI and exploring the underlying mechanisms.

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Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men

Cited by 279 publications

References 42 publications

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Assessment of Motor Units in Neuromuscular Disease

Motor unit number estimation of the tibialis anterior muscle in spinal cord injury

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