Mould biodiversity in homes I. Air and surface analysis of 130 dwellings

Beguin, Hugues; Nolard, N.

doi:10.1007/bf02459231

Cited by 83 publications

(80 citation statements)

References 14 publications

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“…For example, Scedosporium was found in less than 1% of indoor sites analyzed in Belgium, ranking 49th among the 52 genera identified [240]. Nevertheless an appreciable percentage of CF patients are colonized by two or even three genotypes of S. apiospermum [99].…”

Section: Characteristics Of Diseasementioning

confidence: 95%

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

et al. 2006

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Section: Characteristics Of Diseasementioning

confidence: 95%

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

et al. 2006

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“…In the United States, these quantitative differences between Alternaria and Cladosporium are similar but less impressive [4,5,16]. Exposure to fungal spores inside houses is dependent on the quality of the building, the furniture, the bedding, the humidity, and the presence of pets as important determinants for growth of a diversity of fungal species [5,17,18] and on numbers of outdoor fungi [4].…”

Section: Exposure To Fungal Biomassmentioning

confidence: 98%

Exposure, sensitization, and mechanisms of fungus-induced asthma

Kauffman¹,

Heide²

2003

Curr Allergy Asthma Rep

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Healthy individuals are continuously exposed to fungal biomass, which includes live and dead spores and fungal debris that is entrapped in the airways. In patients with asthma and/or atopy, exposure to fungal biomass might result in age-dependent sensitization and asthmatic reactions. Interaction with Toll-like receptors (TLRs) of the innate immune defense (alveolar macrophages and epithelial cells) and protease-activated receptors (PARs) determine the effectiveness of elimination of fungal material. The association of sensitization to Alternaria with severe asthma is discussed in relation to the age-dependent sensitization, rate of release of allergens from spores, and activity of its proteases. A model is described concerning the influence of polymorphic genes for airway hyperresponsiveness (AHR) and atopy, showing a cumulating influence on susceptibility for allergen-induced asthma, and explaining that fungus-induced airway obstruction is mainly associated with more severe asthma.

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“…Scedosporium spp. are isolated in Ͻ1% of dwellings and do not appear to be frequent colonizers of humans (28).…”

Section: Epidemiology Of Human Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

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Mould biodiversity in homes I. Air and surface analysis of 130 dwellings

Cited by 83 publications

References 14 publications

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

Exposure, sensitization, and mechanisms of fungus-induced asthma

Infections Caused byScedosporiumspp

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