Mouse aggression and the intruder-familiarity effect: Evidence for multiple-factor determination.

Connor, James L.; Lynds, P. G.

doi:10.1037/h0077318

Cited by 24 publications

(16 citation statements)

References 24 publications

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“…is compatible with findings that subordinate mice, but not dominant or singly-housed mice, show a conditioned place preference for a chamber associated with their own bedding odors [27]. Such a view may be consonant with the classic finding that group-housed males are less aggressive than singly-housed males regardless of establishment of their social dominancy [12,17,19]. …”

Section: Discussionsupporting

confidence: 83%

Social features of scent-donor mice modulate scent marking of C57BL/6J recipient males

Arakawa¹,

Arakawa²,

Blanchard³

et al. 2009

Behavioural Brain Research

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Territorial male mice can form familiarity-dependent amicable relationships, suggesting that they manage their territorial aggressiveness based on individual recognition, which may be mediated by olfactory signals. The present study demonstrated modulatory effect of odorant cues from mice of different social/housing groups on territorial scent marking by C57BL/6J males. Pair-housed males deposited few scent marks in a novel situation without mouse odors, while singly-housed males marked more in the same situation (Experiment 1). However, when confronted by a conspecific, singly-housed males made fewer marks to pair-housed than to singly-housed stimulus males, while pair-housed males showed few marks to either stimulus animal (Experiment 2). Reduction in scent marking in singly-housed males was also seen on exposure to urine scent alone from a pair-housed male, indicating that the inhibitory cue is mediated by urinary odor (Experiment 3). This inhibitory odor was effective even when singly-housed males were placed in a no-odor environment following exposure to soiled bedding used by pair-housed males (Experiment 4). When singly-housed males were exposed to scent from subordinate males, they showed less marking than when the stimulus scent was from dominants or singly-housed males (Experiment 5). Scent marking was not influenced by the total amount of urine scent marks deposited on the substrates (Experiment 6), suggesting that it is a particular component in urinary odor rather than the magnitude of the odor, that plays a significant role in recipient behavior. Together, these experiments indicate that conspecific male odor signals modulate territorial scent marking behavior in mice.

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Section: Discussionsupporting

confidence: 83%

Social features of scent-donor mice modulate scent marking of C57BL/6J recipient males

Arakawa¹,

Arakawa²,

Blanchard³

et al. 2009

Behavioural Brain Research

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show abstract

“…The index used in these studies was the time spent in an area with odor, and the definitions of the dominants and subordinates were based on judgements of "stronger" and "weaker" mice that were separated with wire mesh dividers. Mice kept in a cage with wire mesh dividers between them are not cohabitants (Connor & Lynds 1977). Difference of the index and difference of the definition of dominance status could have brought about the differences in the conclusions between this study and others.…”

Section: Responses To the Odor Of Unfamiliar Mice By The Dominants Anmentioning

confidence: 93%

The differential responses to the odor of unfamiliar male conspecifics in dominant, subordinate, and isolated mice

Koyama¹

1995

J. Ethol.

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--Male ddY mice were used to investigate the responses toward the odor of unfamiliar male mice. They were reared either in isolation from 3 weeks of age or in pairs. At 10 weeks of age, they went through a 4-day test period, in which the responses of the mice toward the odor of unfamiliar dominant and subordinate mice were investigated by differentiating the responses into the time to investigate the odor and the final decision of avoidance or preference. All the mice went through the encounter tests after this odor test in order to investigate the relationship between the responses toward the odor and the behavior toward the odor donor.The pair-reared dominants and the subordinates responded to the odor of the dominant and subordinate mice differentially. This indicated that they could discriminate the dominance status of unfamiliar mice by odor. Isolated mice did not respond to the odor of the dominant and subordinate mice differentially. Social experiences were concluded to be necessary to discriminate the dominance status of unfamiliar mice through odor.The length of the investigation time and the final decision of avoidance or preference did not correlate in pair-reared or isolated mice, and these 2 scales were concluded to be different. But the dominant mice that investigated the odor for longer periods tended to show aggression in the later encounter test.

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“…The use of individually housed subject males, the most commonly used approach, is not optimum. A lack of cage mates for the singly housed subject contributes to an aggressive response to the intruder male26,27,28 and increases attempts to mount when presented with a stimulus female29. For the latter situation, it is necessary to extinguish sex behavior over a period of days11,15 so that the male will engage in investigatory behavior, not just sexual behavior.…”

Section: Introductionmentioning

confidence: 99%

Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition

2009

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Social recognition (SR) enables rodents to distinguish between familiar and novel conspecifics, largely through individual odor cues. SR tasks utilize the tendency for a male to sniff and interact with a novel individual more than a familiar individual. Many paradigms have been used to study the roles of the neuropeptides oxytocin and vasopressin in SR. However, inconsistencies in results have arisen within similar mouse strains, and across different paradigms and laboratories, making reliable testing of social recognition difficult. The current protocol details a novel approach that is replicable across investigators and in different strains of mice. We created a protocol that utilizes gonadally intact, singly housed females presented within corrals to group-housed males. Housing females singly prior to testing is particularly important for reliable discrimination. This methodology will be useful for studying short-term social memory in rodents, and may also be applicable for longer-term studies.

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Mouse aggression and the intruder-familiarity effect: Evidence for multiple-factor determination.

Cited by 24 publications

References 24 publications

Social features of scent-donor mice modulate scent marking of C57BL/6J recipient males

Social features of scent-donor mice modulate scent marking of C57BL/6J recipient males

The differential responses to the odor of unfamiliar male conspecifics in dominant, subordinate, and isolated mice

Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition

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