Mouse brain magnetic resonance microscopy: Applications in Alzheimer disease

Abstract

Over the past two decades, various Alzheimer's disease (AD) trangenetic mice models harboring genes with mutation known to cause familial AD have been created. Today, high-resolution magnetic resonance microscopy (MRM) technology is being widely used in the study of AD mouse models. It has greatly facilitated and advanced our knowledge of AD. In this review, most of the attention is paid to fundamental of MRM, the construction of standard mouse MRM brain template and atlas, the detection of amyloid plaques, following up on brain atrophy and the future applications of MRM in transgenic AD mice. It is believed that future testing of potential drugs in mouse models with MRM will greatly improve the predictability of drug effect in preclinical trials.

Automatic Mouse Brain MRM Parcellation Based on Tomographic Atlas

“…A recent study of five diffeomorphic image registration algorithms have shown that Geodesic-SyN [11] is remarkable successful for mouse brain registration. Here, we used the optimal parameters proposed by Fu [12] (gradient step length at 1, time points at 2, integration time discretisation step at 0.05, the Gauss parameters for the velocity field and deformation field at [3,2], CC as the similarity metric for diffeomorphic transform, whereas MI as the similarity metric for affine registration, the number of iterations is [100, 100, 30] , and window radius at 2). …”

“…Thus, atlas based brain segmentation has also been extended from human to mouse [2]. A number of groups have delineated brain ROIs in mouse MR microscopy (MRM) for atlas based parcellation .…”

Symmetric image normalization for mouse brain magnetic resonance microscopy

“…The signal to noise ratio (SNR) is poor, morphological change is more subtle, and brain anatomy is quite different [15], which raise the question to existing registration algorithms. The performance of SyN registration is subject to several adjustable parameters(regularization, similarity measures in transformation, transformation model, iterations and window radius).…”

Evaluation of five diffeomorphic image registration algorithms for mouse brain magnetic resonance microscopy

“…Transgenic mice (Van der Weyden & Bradley, ) have been widely used in neuroscience research for understanding the mechanism of disease‐related abnormalities such as AD (Alzheimer's Disease), PD (Parkinson's Disease) etc. (Schaeffer et al ., ; Lin et al ., ; Perruolo et al ., ). Ultra‐high magnetic field, matched physical devices and optimised acquisition sequences are required to develop MRI at microscopy level as magnetic resonance microscopy (MRM) (Driehuys et al ., ; Badea & Johnson, ).…”

“…Transgenic mice (Van der Weyden & Bradley, 2006) have been widely used in neuroscience research for understanding the mechanism of disease-related abnormalities such as AD (Alzheimer's Disease), PD (Parkinson's Disease) etc. (Schaeffer et al, 2011;Lin et al, 2015;Perruolo et al, 2016). Ultra-high Correspondence to: Lan Lin, Biomedical Engineering Department, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China.…”