1994
DOI: 10.1016/0731-7085(94)00093-x
|View full text |Cite
|
Sign up to set email alerts
|

Mouse hepatic metabolites of ketoconazole: Isolation and structure elucidation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

4
23
0

Year Published

2000
2000
2023
2023

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 27 publications
(27 citation statements)
references
References 6 publications
4
23
0
Order By: Relevance
“…Metabolites, typified in the in vivo metabolism of ketoconazole, ciprofloxacin, the inotropic agent , and the phenothiazine derivative perazine, include carbinolamine, amide, ring-opened, and N-oxidation products (Breyer, 1972;Gau et al, 1986;Miyamoto et al, 1988;Whitehouse et al, 1994). The hydroxylamine intermediate, formed by oxidation of the secondary amine, if present, is rarely observed in vivo for piperazines or other nitrogen-containing alicycles.…”
mentioning
confidence: 99%
“…Metabolites, typified in the in vivo metabolism of ketoconazole, ciprofloxacin, the inotropic agent , and the phenothiazine derivative perazine, include carbinolamine, amide, ring-opened, and N-oxidation products (Breyer, 1972;Gau et al, 1986;Miyamoto et al, 1988;Whitehouse et al, 1994). The hydroxylamine intermediate, formed by oxidation of the secondary amine, if present, is rarely observed in vivo for piperazines or other nitrogen-containing alicycles.…”
mentioning
confidence: 99%
“…The products P and P H may presumably resemble the metabolites of KC Á , oxidation, cleavage and degradation of the imidazole and piperazine rings, o-dealkylation and aromatic hydroxylation are the reported pathways of KC metabolisms [26].…”
Section: Mechanismmentioning
confidence: 99%
“…Ketoconazole undergoes extensive metabolism in the liver to form several metabolites (Whitehouse et al, 1994). About 2 to 4% of urinary radioactivity represents unchanged drug (Heel et al, 1982).…”
Section: Case Studiesmentioning
confidence: 99%