Mouse killing and hyperreactivity following lesions of the medial hypothalamus, the lateral septum, the bed nucleus of the stria terminalis, or the region ventral to the anterior septum

Albert, D.J.; Brayley, K.N.

doi:10.1016/0031-9384(79)90040-4

Cited by 71 publications

(5 citation statements)

References 13 publications

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“…Selective pharmacological inactivation of the LS has been found to reduce anxiety in ethological tests of anxiety [27,28]. This finding is, however, difficult to reconcile with reports of ''septal or sham rage'' (increased defensive behaviors to innocuous stimuli) following LS lesions [29,30] or demonstrations of reduced anxiety-like behavior when the LS is electrically stimulated [31]. Recent studies employing circuit-specific approaches have sought to further elucidate the role of the ventral hippocampus-LS pathway in anxiety and feeding regulation, but these have also been inconsistent.…”

Section: Resultsmentioning

confidence: 97%

Ventral Hippocampal CA1 and CA3 Differentially Mediate Learned Approach-Avoidance Conflict Processing

et al. 2018

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Approach-avoidance conflict arises when an animal encounters a stimulus that is associated simultaneously with positive and negative valences [1]. The effective resolution of approach-avoidance conflict is critical for survival and is believed to go awry in a number of mental disorders, such as anxiety and addiction. An accumulation of evidence from both rodents and humans suggests that the ventral hippocampus (anterior in humans) plays a key role in approach-avoidance conflict processing [2-8], with one influential model proposing that this structure modulates behavioral inhibition in the face of conflicting goals by increasing the influence of negative valences [9]. Very little is known, however, about the contributions of specific hippocampal subregions to this process-an important issue given the functional and anatomical heterogeneity of this structure. Using a non-spatial cue-based paradigm in rats, we found that transient pharmacological inactivation of ventral CA1 produced an avoidance of a conflict cue imbued with both learned positive and learned negative outcomes, whereas inactivation of the ventral CA3 resulted in the opposite pattern of behavior, with significant preference for the conflict cue. In contrast, dorsal CA1- and CA3-inactivated rats showed no change in conflict behavior, and furthermore, additional behavioral tasks confirmed that the observed pattern of approach-avoidance findings could not be explained by other factors, such as differential alterations in novelty detection or locomotor activity. Our data demonstrate that ventral CA1 and CA3 subserve distinct and opposing roles in approach-avoidance conflict processing and provide important insight into the functions and circuitry of the ventral hippocampus.

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Section: Resultsmentioning

confidence: 97%

Ventral Hippocampal CA1 and CA3 Differentially Mediate Learned Approach-Avoidance Conflict Processing

et al. 2018

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“…The septum itself, which contains these hippocampal efferents, is a relatively ineffective site for inducing increased aggression using lesions. The more effective site in this general area is ventral to the lateral septum along the medial edge of the rostral limb of the anterior commissure (Albert and Brayley 1979;Albert and Richmond 1975;Albert and Wong 1978£>). Finally, there is little evidence that the lateral septum or the region ventral to the anterior septum modulates aggression by way of input to the ventromedial nucleus since the reactivity to the experimenter induced by medial hypothalamic lesions is suppressed by stimulation in the region of the septum (Brayley and Albert 1977).…”

Section: Open Peer Commentarymentioning

confidence: 99%

“…However, the detailed development of the model is concerned primarily with intraspecific aggression Existing evidence itself suggests that intraspecific aggression is modulated by the medial hypothalamus in the same way as an attack on a mouse (Albert and Wong 1978a). Defensiveness, as manifested in increased reactivity to an experimenter, is modulated independently of the tendency to attack a mouse or another rat (Albert and Brayley 1979;Albert and Wong 1978a;Eclancher and Karli 1971;Panksepp 1971a). Because it appears that the medial hypothalamus modulates a broad spectrum of interspecific and intraspecific aggressive behavior, Adams's suggestion that the medial hypothalamus regulates defense-submission seems too limited.…”

Section: Open Peer Commentarymentioning

confidence: 99%

Brain mechanisms for offense, defense, and submission

Adams

1979

Behav Brain Sci

395

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A preliminary attempt is made to analyze the intraspecific aggressive behavior of mammals in terms of specific neural circuitry. The results of stimulation, lesion, and recording studies of aggressive behavior in cats and rats are reviewed and analyzed in terms of three hypothetical motivational systems: offense, defense, and submission. A critical distinction, derived from ethological theory, is made between motivating stimuli that simultaneously activate functional groupings of motor patterning mechanisms, and releasing and directing stimuli that are necessary for the activation of discrete motor patterning mechanisms. It is suggested that motivating stimuli activate pathways that converge upon sets of homogeneous neurons, called motivational mechanisms, whose activity determines the motivational state of the animal.A defense motivational mechanism is hypothesized to be located in the midbrain central gray. In addition to tactile, auditory, and visual inputs from the paleospinothalamic tract, lateral lemniscus, and (perhaps) from the pretectum, it may receive inputs from a major forebrain pathway whose functional significance is not yet understood.A submission motivational mechanism is also thought to be located in the central gray. In addition to inputs for defense, it is thought to receive a necessary input from a “consociate (social familiarity cue) modulator” located in the ventromedial hypothalamus, which can switch behavior from defense to submission. The location of the hypothetical offense motivational mechanism is not known, although the pathways by which it is activated are traced in some detail.Brain mechanisms of aggression in primitive mammals and in primates are apparently similar to those in rats and cats.

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“…Unfortunately, due to the lack of appropriate animal models, little is known about the neurochemical transformations that take place when an animal switches from expressing one type of behavior, such as social affiliation, to another, such as aggression (McNamara et al,2005). Nonetheless, the results from early studies indicate the involvement of brain structures, such as the anterior hypothalamus (AH; Ferris and Potegal,1988; Adams et al,1993; Delville et al,2000; DeLeon et al,2002b; Albers et al,2006) and lateral septum (Albert and Brayley,1979; David et al,2004; Knyshevski et al,2005a; Trainor et al,2006), and neurochemicals, such as vasopressin (AVP; Ferris et al,1997), dopamine (DA; Ago and Matsuda,2003; Ferrari et al,2003), oxytocin (OXT; Ebner et al,2005), and serotonin (5‐HT; Ago and Matsuda,2003; Ferrari et al,2003; Ferris et al,1997), in the regulation of the onset of aggressive behavior.…”

mentioning

confidence: 99%

Anterior hypothalamic neural activation and neurochemical associations with aggression in pair‐bonded male prairie voles

Gobrogge

Liu

Jia

et al. 2007

J of Comparative Neurology

157

163

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Male prairie voles (Microtus ochrogaster) display mating-induced pair bonding indicated by social affiliation with their female partners and aggression toward unfamiliar conspecifics. In the present study, we characterized their aggression associated with pair bonding and examined the related neuronal activation and neurochemical architecture. Males that were pair-bonded for 2 weeks displayed intense levels of aggression toward a female or male conspecific stranger but maintained a high level of social affiliation with their familiar female partners. These social interactions induced increases in neural activation, indicated by increased density of Fos-immunoreactive staining (Fos-ir) in several brain regions including the bed nucleus of the stria terminalis (BNST), medial preoptic area (MPOA), paraventricular nucleus (PVN), anterior cortical (AcA), and medial nuclei (MeA) of the amygdala. In the anterior hypothalamus (AH), increased density of Fos-ir staining was found specifically to be associated with aggression toward unfamiliar female or male strangers. In addition, higher densities of AH cells that were stained for tyrosine hydroxylase (TH) or vasopressin (AVP) were also labeled with Fos-ir in these males displaying aggression toward a conspecific stranger compared with males displaying social affiliation toward their female partner. Together, our results indicate that dopamine and vasopressin in the AH may be involved in the regulation of enduring aggression associated with pair bonding in male prairie voles.

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Mouse killing and hyperreactivity following lesions of the medial hypothalamus, the lateral septum, the bed nucleus of the stria terminalis, or the region ventral to the anterior septum

Cited by 71 publications

References 13 publications

Ventral Hippocampal CA1 and CA3 Differentially Mediate Learned Approach-Avoidance Conflict Processing

Ventral Hippocampal CA1 and CA3 Differentially Mediate Learned Approach-Avoidance Conflict Processing

Brain mechanisms for offense, defense, and submission

Anterior hypothalamic neural activation and neurochemical associations with aggression in pair‐bonded male prairie voles

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