Mouse models in modeling aging and cancer

Li, Haili; Wei, Chu; Zhou, Ruoyu; Wang, Boyuan; Zhang, Yongjin; Shao, Chihao; Luo, Ying

doi:10.1016/j.exger.2019.03.002

Cited by 11 publications

(10 citation statements)

References 84 publications

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“…Excessive uptake of d -gal will change it into non-degradable galactitol, which when accumulated will induce the production of free radicals, leading to tissue injury and organ degradation. 19 d -Gal subcutaneous injection for 8 weeks would inevitably develop oxidative stress and organ degeneration, especially observed in the brain and liver.…”

Section: Discussionmentioning

confidence: 99%

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota

Sheng

Yang

et al. 2022

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota

Sheng

Yang

et al. 2022

Food Funct.

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“…Unfortunately, to date, these processes have been difficult to study in the common laboratory mouse, M. musculus, due to its extremely long telomeres. Attempts to study the implications of short telomeres in mice have thus far been based on telomerase null alleles, which cause ever-shortening telomeres and eventually result in severe pathologies and infertility, or on manipulating telomere proteins to induce overt telomere deprotection (Chakravarti et al ., 2021; Li et al, 2019). These existing mouse models are limited by their inability to maintain short but stable telomeres with function and lengths comparable to those of humans.…”

Section: Discussionmentioning

confidence: 99%

Telomouse – a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Smoom

May

Ortiz

et al. 2021

Preprint

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Maintaining optimal telomere length throughout life limits cancer and enables healthy aging. Yet, it is unclear how the telomere length set point is determined. Telomeres in the house mouse, Mus musculus, are 2-4 times longer than human telomeres, limiting the use of the mouse as a model for telomere research. By introducing a single amino acid variation found in M. spretus into the helicase RTEL1 of M. musculus, we shortened its telomere length set point 2-3 times, implicating this variation in the dramatic difference in telomere length between the two mouse species. While the engineered mice are fertile and healthy, hepatocytes with short telomeres displayed reduced proliferation capacity. This 'telomouse' is a unique model for studying the implications of short telomeres in aging and cancer.

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“…These tools may be significant in therapeutic strategies for studying aging or cancer. Recent reviews have summarized mouse models modeling aging and cancer [ 37 , 38 ]. These models generated to explore the signaling pathways manifest either aging or cancer phenotypes, sometimes both, which worked well for understanding the correlation between aging and cancer.…”

Section: Novel Strategy For Generating Age-related Cancer Models In Micementioning

confidence: 99%

A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression

Zhang

Jazwinski²

2022

Cancers

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Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. Recognition of the connections between aging and cancer and improvement of treatment for elderly cancer patients has become one of the most critical medical issues with the global increase in the elderly population. Mouse models are essential experimental tools for understanding the molecular mechanisms of complex processes and related gene pathways of biological aging. However, few mouse models can be used to understand the role of aging in cancer development and the underlying mechanisms. One of the hallmarks of aging is chronic inflammation, often called inflammaging. This is our rationale for examining the role of aging-related inflammation in prostate cancer, a major aging malignancy. We have now developed a novel method to generate age-related cancer models in mice to better understand how age impacts cancer initiation and progression in the natural aging process. We discuss its application to elucidate some of the contributing mechanisms.

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Mouse models in modeling aging and cancer

Cited by 11 publications

References 84 publications

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota

Telomouse – a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression

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