Mouse Phenome Database (MPD)

Bogue, Molly A.; Grubb, Stephen C.; Maddatu, Terry P.; Bult, Carol J.

doi:10.1093/nar/gkl1049

Cited by 85 publications

(70 citation statements)

References 9 publications

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“…In recent years, phenotypic datasets for measures of behavior and neurosensory function, as well as anatomy, blood chemistry, drug effects, and multiple other parameters, have been assembled into the Mouse Phenome Database (MPD), housed at JAX ( [4]; http://www.jax.org/phenome). The inbred strains for our studies on mouse behavioral tasks relevant to autism were predominantly from the groups given highest priority for phenotyping by the Mouse Phenome Project.…”

Section: Discussionmentioning

confidence: 99%

Social approach and repetitive behavior in eleven inbred mouse strains

Moy

Nadler

Young³

et al. 2008

Behavioural Brain Research

222

211

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Core symptoms of autism include deficits in social interaction, impaired communication, and restricted, repetitive behaviors. The repetitive behavior domain encompasses abnormal motoric stereotypy, an inflexible insistence on sameness, and resistance to change. In recent years, many genetic mouse models of autism and related disorders have been developed, based on candidate genes for disease susceptibility. The present studies are part of an ongoing initiative to develop appropriate behavioral tasks for the evaluation of mouse models relevant to autism. We have previously reported profiles for sociability, preference for social novelty, and resistance to changes in a learned pattern of behavior, as well as other functional domains, for 10 inbred mouse strains of divergent genetic backgrounds. The present studies extend this multi-component behavioral characterization to several additional strains: C58/J, NOD/LtJ, NZB/B1NJ, PL/J, SJL/J, SWR/J, and the wild-derived PERA/ EiJ. C58/J, NOD/LtJ, NZB/B1NJ, SJL/J, and PERA/EiJ demonstrated low sociability, measured by time spent in proximity to an unfamiliar conspecific, with 30% to 60% of mice from these strains showing social avoidance. In the Morris water maze, NZB/B1NJ had a persistent bias for the quadrant where the hidden platform was located during acquisition, even after nine days of reversal training. A particularly interesting profile was found for C58/J, which had low social preference, poor performance in the T-maze, and overt motoric stereotypy. Overall, this set of tasks and observational methods provides a strategy for evaluating novel mouse models in behavioral domains relevant to the autism phenotype.

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Section: Discussionmentioning

confidence: 99%

Social approach and repetitive behavior in eleven inbred mouse strains

Moy

Nadler

Young³

et al. 2008

Behavioural Brain Research

222

211

View full text Add to dashboard Cite

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“…White cell counts from Clec4e MNA and Clec4e MNB mice were generally low, but within normal ranges reported for C57BL/6J mice (from the Mouse Phenome Database http://www. jax.org/phenome (30,31)). In this current study, circulating white blood cell counts of Clec4e MNA and Clec4e MNB mice were 20% lower than those of control C57BL/6J mice ( p Ͻ 0.05), and this depression was observed across neutrophil (25% lower), monocyte (15% lower), and lymphocyte (19% lower) counts.…”

Section: Phenotype Of Mincle Gene Ko Micementioning

confidence: 99%

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

Wells

Salvage-Jones

et al. 2008

The Journal of Immunology

408

369

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The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-α by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.

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“…Alternatively, for mouse research, an additional online tool that permits haplotype analysis across the entire genome for 16 strains of inbred mice is available through the Mouse Phenome Database (http://www.jax.org/phenome) (Bogue et al 2007). Since the resolution of both haplotype analysis and haplotype association mapping is finer than the 1.0-Mb resolution of our maps in Figure 1, we suggest simultaneously mapping your results from these analyses onto a complete gene list for the relevant chromosomal interval.…”

Section: Combined Cross Analysismentioning

confidence: 99%

Practical Applications of the Bioinformatics Toolbox for Narrowing Quantitative Trait Loci

Burgess-Herbert¹,

Cox

Tsaih

et al. 2008

Genetics

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Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable expressivity of traits. Although quantitative trait locus (QTL) analysis has been a powerful tool for localizing the chromosomal regions underlying complex traits, systematically identifying the causal genes remains challenging. Here, through its application to plasma levels of high-density lipoprotein cholesterol (HDL) in mice, we demonstrate a strategy for narrowing QTL that utilizes comparative genomics and bioinformatics techniques. We show how QTL detected in multiple crosses are subjected to both combined cross analysis and haplotype block analysis; how QTL from one species are mapped to the concordant regions in another species; and how genomewide scans associating haplotype groups with their phenotypes can be used to prioritize the narrowed regions. Then we illustrate how these individual methods for narrowing QTL can be systematically integrated for mouse chromosomes 12 and 15, resulting in a significantly reduced number of candidate genes, often from hundreds to ,10. Finally, we give an example of how additional bioinformatics resources can be combined with experiments to determine the most likely quantitative trait genes.

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Mouse Phenome Database (MPD)

Cited by 85 publications

References 9 publications

Social approach and repetitive behavior in eleven inbred mouse strains

Social approach and repetitive behavior in eleven inbred mouse strains

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

Practical Applications of the Bioinformatics Toolbox for Narrowing Quantitative Trait Loci

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