1998
DOI: 10.1006/bbrc.1998.9636
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Mouse Placental Cells Secrete Soluble Leptin Receptor (sOB-R): cAMP Inhibits sOB-R Production

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Cited by 26 publications
(22 citation statements)
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“…In mice, the circulating concentration of the soluble form of the leptin receptor (Re) is markedly (40-fold) raised in pregnancy and, by binding leptin and inhibiting its metabolism, 40 it appears to be responsible for a rise of similar magnitude in circulating leptin levels. 41 Since placental cells secrete soluble leptin receptor, 42 it is possible that reduced production of a binding protein around the time of parturition greatly enhanced the metabolism of the infused leptin. In addition, there may be a significant clearance of leptin bound to placenta 43 and decidua.…”
Section: Discussionmentioning
confidence: 99%
“…In mice, the circulating concentration of the soluble form of the leptin receptor (Re) is markedly (40-fold) raised in pregnancy and, by binding leptin and inhibiting its metabolism, 40 it appears to be responsible for a rise of similar magnitude in circulating leptin levels. 41 Since placental cells secrete soluble leptin receptor, 42 it is possible that reduced production of a binding protein around the time of parturition greatly enhanced the metabolism of the infused leptin. In addition, there may be a significant clearance of leptin bound to placenta 43 and decidua.…”
Section: Discussionmentioning
confidence: 99%
“…The CHO cell clone, which stably expresses rat OB-Re (Yamaguchi et al 1998), was incubated with serum-free medium S-Clone SF-02 (Sanko Junyaku Co. Ltd, Tokyo, Japan). The conditioned media was dialyzed against buffer A (25 mM HEPES (pH 7·4), 100 mM NaCl), followed by two passes through a wheat germ lectin Sepharose 6 MB column (Amersham Pharmacia Biotech Ltd, Amersham, Bucks, UK).…”
Section: Partial Purification Of Rat Ob-rementioning
confidence: 99%
“…The resulting protein was used as the antigen for immunizing Hartley guinea pigs (obtained from Japan SLC, Inc.) and anti-OB-R antiserum was obtained as described previously (Yamaguchi et al 1998).…”
Section: +mentioning
confidence: 99%
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“…Many studies have validated this cell model for studying aspects of trophoblast biology including cell cycle regulation, cell differentiation regulation, trophoblast phenotypic characterization, cell invasion, and trophoblast tumor development [14,16,24,[30][31][32][33][34][35]. Differentiation of Rcho-1 cells to yield cells with a trophoblast giant cell phenotype helps overcome the inherent difficulties in obtaining purified populations of these cells from tissues [16].…”
Section: Discussionmentioning
confidence: 99%