Mouse strain differences in plasma corticosterone following uncontrollable footshock

Shanks, Nola; Griffiths, Jenna; Zalcman, Steve; Zacharko, Robert M.; Anisman, Hymie

doi:10.1016/0091-3057(90)90249-h

Cited by 151 publications

(74 citation statements)

References 21 publications

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“…Additionally, genetic differences among the strains of mice used in EE studies may, in part, contribute to the divergent results. The BALB/c strain used in our studies is relatively anxious, with higher concentrations of basal serum corticosterone and lower rates of corticosterone catabolism, which may amplify the effects of cage enrichment on reduction of corticosterone production (39,40). In contrast, the above studies that found increased corticosterone concentrations in EE-caged mice used C57BL/6 and C3H/eB strains.…”

Section: Discussioncontrasting

confidence: 47%

Environmental Enrichment Alters Splenic Immune Cell Composition and Enhances Secondary Influenza Vaccine Responses in Mice

Gurfein

Davidenko

Premenko-Lanier

et al. 2014

Mol Med

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Section: Discussioncontrasting

confidence: 47%

Environmental Enrichment Alters Splenic Immune Cell Composition and Enhances Secondary Influenza Vaccine Responses in Mice

Gurfein

Davidenko

Premenko-Lanier

et al. 2014

Mol Med

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“…Cabib et al (1990) reported that C57BL/6 show a larger increase in plasma corticosterone levels than DBA/2 mice after a 30min exposure to an unfamiliar environment, with glucocorticoid concentrations returning back to basal values after 60 min in mice of the C57BL/6 strain and after 90 min in DBA/2 mice. In addition, it has been observed that DBA/2 mice exhibit a more prolonged elevation of corticosterone levels following inescapable footshocks (Shanks et al, 1990).…”

Section: Article In Pressmentioning

confidence: 99%

“…C57BL/6 and DBA/2 inbred mice have previously been used as a genetic animal model for anxiety-related and depression-like behavior (Crawley et al, 1997;Griebel et al, 1997;Ohl et al, 2003;Jacobson and Cryan, 2007) as well as a model of distinct hippocampal functioning regarding learning and memory (Ammassari-Teule et al, 2000;Passino et al, 2002). Moreover, it has been reported that mice of both strains show differences in glucocorticoid hormone responses towards stress but not under basal conditions (Cabib et al, 1990;Jones et al, 1998;McNamara et al, 2003;Shanks et al, 1990). However, the estimation of basal hormone action and HPA system regulation is rather complicated in these two inbred strains as they differ in their plasma concentrations of corticosterone binding globuline (Jones et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

Thoeringer

Sillaber²,

Roedel

et al. 2007

Psychoneuroendocrinology

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SummaryThere is strong evidence for a pivotal interaction of corticosteroid signalling and behavioral adaptation to stress. To further elucidate this relation, we monitored the dynamics of free corticosterone in the murine hippocampus of two inbred mouse strains using in vivo microdialysis. C57BL/6JOlaHsd (C57BL/6) and DBA/2OlaHsd (DBA/2) inbred mouse strains have been shown to differ in their anxiety-related and depression-like behavior and provide, thus, an interesting animal model to study the stimulus-response profile of the hypothalamus-pituitary-adrenocortical (HPA) system as a function of emotional and physical load. We, first, compared peripheral and intracerebral concentration patterns of corticosterone by simultaneous microdialysis of the jugular vein and the hippocampus in anesthetized mice and found strain differences in blood versus intracerebral free corticosterone concentrations. C57BL/6 showed almost the same steroid levels in either compartment, whereas DBA/2 mice displayed higher glucocorticoid levels in the circulation than in the hippocampus. This data suggest a strain difference in the tissue environment influencing the amount of biological active corticosterone at the receptor site. Measurements of intrahippocampal corticosterone in freely moving mice revealed that DBA/2 display a prolonged glucocorticoid increase in response to a single forced swimming stress (FST), as compared to C57BL/6 mice indicating a reduced inhibitory HPA axis feedback. Exposure to a novel environment (NE) induced a desensitization of the HPA system in DBA/2 animals as they show an attenuated intracerebral corticosterone dynamics after a subsequent FST. Testing animals in an elevated plus-maze (EPM), however, did not significantly stimulate coriticosterone release in either strain. The analysis of the area under the curve revealed a high amount of corticosterone released through FST and a low glucocorticoid release after NE or EPM exposure that are independent of the strain. This data indicate a strong stimulus dependency of corticosterone secretion that is strain independent, whereas the dynamics and feedback of the HPA axis is different between both inbred strains. Behavioral phenotyping of animals revealed a strong impact of microdialysis procedure on FST and EPM performance. Innate emotionality differences of both strains, however, were not affected. Though descriptive in nature, the present results suggest an altered corticosteroid signalling in the DBA/2 strain compared to C57BL/6 mice. Whether this observation causally underlies the differences in anxiety-related and depression-like behavior has to be further experimentally validated. In addition, our study highlights the use of in vivo microdialysis to assess the neuroendocrine endophenotype of animal models via profiling of stimulus-response patterns of stress hormones. ARTICLE IN PRESS

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“…To minimize the effect of sampling order on the values of corticosterone and thyroxine (described by Gä rtner et al 1980, Shanks et al 1990, Dahlborn et al 1996, four mice were euthanized together in their home cage and sampling was done alternating in groups of one cage per each group (NE, E1, E2). The sampling order was unalterable until all of the animals had been euthanized.…”

Section: Euthanasiamentioning

confidence: 99%

Are the effects of different enrichment designs on the physiology and behaviour of DBA/2 mice consistent?

et al. 2003

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SummaryEnvironmental enrichment is intended to improve the well-being of laboratory animals. Although many researchers have indicated that environmental enrichment may enhance animal well-being, there is some evidence that enrichment differs in its effects on physiology and behaviour between species and strains. The present study focuses on the effects of different enrichment designs on the physiology and behaviour of male and female DBA=2 mice. A total of 48 DBA=2J mice, 24 males and 24 females were used for this experiment. Upon arrival at about 3 weeks of age, the animals were randomly allotted to three experimental groups: NE, non-enrichment; E1, enriched with nest box, wooden climbing bar and nest material according to Scharmann (1993); E2, enriched with horizontal and vertical dividers, modi ed from Haemisch and Gä rtner (1994). Same-sex groups of four mice were housed for 12 weeks in type III Makrolon cages with (E1 or E2) or without (NE) enrichment objects. Behavioural performance (Open Field, Food Drive and Elevated Plus Maze tests) and physiological traits (haematological variables, body weight and organ weights, corticosterone and thyroxine levels) were measured. This study observed that enrichment had signi cant effects on the mean values of body weight (females), Open Field and Food Drive tests. The most signi cant housing differences were found between the E2 and NE=E1 groups. Furthermore, sex differences in the NE, E1 and E2 groups were not consistent for several variables (growth rate, relative weights of spleen, kidney and heart, Food Drive and Elevated Plus Maze behavioural performance). There was often a higher coef cient of variation (CV) in the E1 and E2 groups as compared to the NE group, chie y in physiological traits and in the Open Field and Food Drive tests. The results of this study indicate, that the effects of enrichment designs used in the present study are not consistent, but vary according to sex and the variable studied.

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Mouse strain differences in plasma corticosterone following uncontrollable footshock

Cited by 151 publications

References 21 publications

Environmental Enrichment Alters Splenic Immune Cell Composition and Enhances Secondary Influenza Vaccine Responses in Mice

Environmental Enrichment Alters Splenic Immune Cell Composition and Enhances Secondary Influenza Vaccine Responses in Mice

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

Are the effects of different enrichment designs on the physiology and behaviour of DBA/2 mice consistent?

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