This paper uses two open science data sources—ORCID and Carnegie Classification of Institutions of Higher Education (CCIHE)—to identify tenure-track and tenured professors in the U.S. who have changed academic affiliations. Through a series of data cleaning and processing, 5,938 professors met the selection criteria of professorship and mobility. Using ORCID professor profiles and the Carnegie Classification, this paper reveals patterns of academic mobility in the U.S. from the aspects of institution types, locations, regions, funding mechanisms of institutions, and professors’ genders. This paper finds that professors tended to move to institutions with higher research intensity such as those with a R1 or R2 designation in the Carnegie Classification. They also tend to move from rural institutions to urban institutions. Additionally, this paper finds that female professors are more likely to move within the same geographic region than male professors and that when they move from a less research-intensive institution to a more research-intensive one, female professors are less likely to retain their rank or attain promotion.