Movement-related potentials in Parkinson’s disease

Georgiev, Dejan; Lange, Florian; Seer, Caroline; Kopp, Bruno; Jahanshahi, Marjan

doi:10.1016/j.clinph.2016.04.004

Cited by 41 publications

(30 citation statements)

References 65 publications

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“…This kind of gait is characteristic feature of Parkinson's disease and is a useful indicator of altered functioning of basal ganglia (Fathalla et al, 2016). Depleted levels of dopamine due to loss of dopaminergic neurons has been associated with altered, planning, control over movements, cortical function and cerebellar dysfunction (Georgiev et al, 2016;Seidel et al, 2017). Polydatin+rotenone treated animals displayed significantly longer stride lengths than parkinsonian rats.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Potential of Polydatin Against Motor Abnormalities and Dopaminergic Neuronal Loss in Rotenone Induced Parkinson Model

Ahmed¹,

Shaikh²,

Baloch³

et al. 2018

Int. J. Morphol.

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SUMMARY:Among the neurodegenerative disorders, Parkinson disease (PD) is ranked as second most common. The pathological hallmark is selective degeneration of the dopaminergic neurons in the nigro-striatal regions of brain with appearance of the Lewy bodies. Present study explores the neuro-protective potential of polydatin in terms of amelioration of degeneration of dopaminergic neurons in nigro-striatal regions of brain and distorted neuromotor behavior in the rotenone model of Parkinson's disease. Thirty-six male Sprague Dawley rats were divided into three groups. Group A (control), Group B (rotenone treated) and Group C (rotenone+polydatin treated). Rotenone was administrated intraperitoneally (i.p) at a dose of 3 mg/kg/body weight while polydatin was given i.p. at a dose of 50 mg/ kg/body weight for four weeks. Then, animals were sacrificed; substantia nigra (SN) & striatum isolated from brain and five micron thick sections were prepared. Cresyl violet (CV), H&E and Immuno-histochemical staining using anti-TH antibody was done. Motor behavior was assessed weekly throughout the experiment using five different methods. Rotenone treated parkinsonian animals showed deterioration of motor behavior, weight loss, loss of dopaminergic neurons and diminished immune-reactivity in the sections from the nigrostriatal regions of these animals Polydatin+rotenone treatment showed contradicting effects to parkinsonism, with amelioration in weight loss, neuro-motor behavior, dopaminergic loss and immune-reactivity against dopaminergic neurons. Present study revealed a neuro-protective potential of polydatin in animal model of PD by ameliorating the neuro-motor abnormalities and degeneration of dopaminergic neurons in nigrostriatal regions.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Potential of Polydatin Against Motor Abnormalities and Dopaminergic Neuronal Loss in Rotenone Induced Parkinson Model

Ahmed¹,

Shaikh²,

Baloch³

et al. 2018

Int. J. Morphol.

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“…To be included in this review, studies were required to report at least one ERP measure recorded from at least two patients with PD (i.e., single-case studies were not considered). Studies focusing on movement-related potentials in PD are reviewed by us in a related article (Georgiev et al, 2016). A small number of studies were published after we had updated our literature review (i.e., during the review and revision process), and these studies (Garrido-Vásquez et al, 2016;Kaufman et al, 2016;Tang et al, 2016) were not included in the systematic overviews presented below.…”

Section: The Present Reviewmentioning

confidence: 99%

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Aside from simple amplitude differences, differences in the temporal course of the CNV could occur between the different ADHD subtypes. Especially the early time periods of the CNV immediately following the presentation of a stimulus indicating the beginning of a preparatory/timing processes have been linked to modulations by arousal and attention 38 . Thus, subtype-specific modulations should especially occur in these early phases of interval timing.…”

Section: Introductionmentioning

confidence: 99%

Neurophysiological mechanisms of interval timing dissociate inattentive and combined ADHD subtypes

Bluschke

Schuster

Roessner

et al. 2018

Sci Rep

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It is far from conclusive what distinguishes the inattentive (ADD) and the combined (ADHD-C) subtype of ADHD on the neuronal level. Theoretical considerations suggest that especially interval timing processes may dissociate these subtypes from each other. Combining high-density EEG recordings with source localization analyses, we examine whether there are ADHD-subtype specific modulations of neurophysiological processes subserving interval timing in matched groups of ADD (n = 16), ADHD-C (n = 16) and controls (n = 16). Patients with ADD and ADHD-C show deficits in interval timing, which was correlated with the degree of inattention in ADD patients. Compared to healthy controls, patients with ADHD-C display a somewhat weaker, yet consistent response preparation process (contingent negative variation, CNV). In patients with ADD, the early CNV is interrupted, indicating an oscillatory disruption of the interval timing process. This is associated with activations in the supplemental motor areas and the middle frontal gyrus. Patients with ADD display adequate feedback learning mechanisms (feedback-related negativity, FRN), which is not the case in patients with ADHD-C. The results suggest that altered pacemaker-accumulation processes in medial frontal structures distinguish the ADD from the ADHD-C subtype. Particularly in patients with ADD phasic interruptions of preparatory neurophysiological processes are evident, making this a possible diagnostic feature.

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Movement-related potentials in Parkinson’s disease

Cited by 41 publications

References 65 publications

Neuroprotective Potential of Polydatin Against Motor Abnormalities and Dopaminergic Neuronal Loss in Rotenone Induced Parkinson Model

Neuroprotective Potential of Polydatin Against Motor Abnormalities and Dopaminergic Neuronal Loss in Rotenone Induced Parkinson Model

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Neurophysiological mechanisms of interval timing dissociate inattentive and combined ADHD subtypes

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