Moxibustion for the Treatment of Cancer and its Complications: Efficacies and Mechanisms

Abstract

Cancer treatment remains a significant challenge for the medical community, and improved therapies are necessary to treat cancer and its associated complications. Current anticancer therapies often have significant side effects, underscoring the need for new treatment options. Moxibustion is a representative external therapy used in traditional Chinese medicine. This review examines clinical studies demonstrating moxibustion’s ability to improve the efficacy of radiotherapy and chemotherapy and control tumor progression. Moxibustion can prevent and treat various complications of cancer, including cancer-related or therapy-induced gastrointestinal symptoms, myelosuppression, fatigue, pain, and postoperative lymphedema. has also been shown to enhance the quality of life for cancer patients. However, very few studies have investigated the underlying mechanisms for these effects, a topic that requires systematic elucidation. Evidence has shown that moxibustion alone or combined with chemotherapy can improve survival and inhibit tumor growth in cancer-bearing animal models. The anticancer effect of moxibustion is associated with alleviating the tumor immunosuppressive and vascular microenvironments. Additionally, the therapeutic effects of moxibustion may originate from the heat and radiation produced during the combustion process on acupoints or lesions. This evidence provides a scientific basis for the clinical application of moxibustion in anticancer treatment and reducing the side effects of cancer therapies and helps promote the precise application of moxibustion in cancer treatment.

Management of Fatigue in Adult Survivors of Cancer: ASCO–Society for Integrative Oncology Guideline Update

“…Several mechanisms may explain its potential efficacy in CRF management, including localized heat application that can enhance blood circulation and potentially improve energy levels. 167 It may also modulate neurotransmitters and regulate the hypothalamic-pituitary-adrenal axis, reduce oxidative stress, and promote relaxation. 167 Acupuncturists select specific points based on the patient's particular symptoms and this tailored approach may enhance treatment outcomes.…”

“…167 It may also modulate neurotransmitters and regulate the hypothalamic-pituitary-adrenal axis, reduce oxidative stress, and promote relaxation. 167 Acupuncturists select specific points based on the patient's particular symptoms and this tailored approach may enhance treatment outcomes. As moxibustion is noninvasive, it is generally well-tolerated and carries minimal risk of adverse effects.…”