Moxifloxacin-Associated Neutropenia in a Cirrhotic Elderly Woman with Lower Extremity Cellulitis

Chang, Chia–Ming; Lee, Nan-Yao; Lee, Hsin‐Chun; Lee, I-Wen; Wu, Chi‐Jung; Lin, Yu-Shiuan; Ko, Wen Chien

doi:10.1345/aph.1k596

Cited by 14 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our patient had findings consistent with moxifloxacin-induced neutropenia. All the three cases which have been reported earlier also had similar presentation[234] [Table 1]. Though reports of ciprofloxacin and norfloxacin-induced neutropenia are available, we could not find any report of cytopenia following levofloxacin administration.…”

mentioning

confidence: 62%

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

et al. 2019

View full text Add to dashboard Cite

mentioning

confidence: 62%

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

et al. 2019

View full text Add to dashboard Cite

“…On day 5, the repeated laboratory tests revealed both worsening leukopenia and neutropenia, so moxifloxacin was withdrawn and oral cefixime was started. On the next days both leukopenia and neutropenia improved [6].…”

Section: Discussionmentioning

confidence: 92%

“…It is also used in neutropenic patients for the treatment of infections [5].Common adverse effects are nausea, diarrhea and dizziness. QT prolongation, fatal arrhythmias and liver injury are uncommon adverse effects [4,6].…”

Section: Introductionmentioning

confidence: 99%

Moxifloxacin-induced neutropenia in 26-year-old man

Ati̇k

İspir

Aytekin

et al. 2018

J Infect Dev Ctries

View full text Add to dashboard Cite

Moxifloxacin is a fourth generation widely used fluoroquinolone antibiotic. There are three cases of moxifloxacin-induced neutropenia reported in the literature and we report the fourth case. A 26-year-old man with pneumonia was treated with moxifloxacin because of penicillin allergy. On the second day of therapy, leukopenia [White blood cell (WBC) count 2.7×10³/μL] and neutropenia (neutrophils 1.21×10³/μL) occurred. Rothia mucilaginosa was isolated in sputum culture. On the fourth day of hospitalization moxifloxacin treatment was stopped and clarithromycin 500 mg PO twice daily was started. Leukopenia and neutropenia resolved one day after discontinuation of moxifloxacin that WBC and neutrophil count rose 4.5×10³/μL and 1.97×10³/μL, respectively. On the sixth day of hospitalization, WBC and neutrophil count was 4.3×10³/μL and 2.29×10³/μL, respectively. The immunomodulatory effects of moxifloxacin may result in the changes of WBC count like leukopenia with neutropenia. Moxifloxacin induced neutropenia may be more common and is an important adverse effect. More observational studies about safety profiles of moxifloxacin are needed.

show abstract

“…The only changes made to medications was discontinuation of moxifloxacin, which led to prompt recovery of WBC. 4 Berk et al detailed another case of moxifloxacin-induced neutropenia in a 32-year-old woman with metastatic breast cancer in remission with lobar pneumonia. Again, viral/fungal infection were excluded, and neutropenia resolved with discontinuation of moxifloxacin.…”

Section: Discussionmentioning

confidence: 99%

A Case of Severe Neutropenia From Short-Term Exposure to Moxifloxacin

Chen

Buren

2017

Journal of Investigative Medicine High Impact Case Reports

View full text Add to dashboard Cite

Moxifloxacin is commonly prescribed in the inpatient and outpatient management of community-acquired pneumonia and other common infections. We report a case of a 76-year-old man who developed severe neutropenia after several days of treatment for community-acquired pneumonia. The patient had a history of alcohol abuse; however, there were no other offending medications prescribed, and a thorough laboratory workup for other possible causes of neutropenia was negative. The patient’s neutrophils and white blood count responded quickly to cessation of fluoroquinolones. This case highlights the importance of identifying patients that might be at high risk for neutropenia that may need closer monitoring on this commonly prescribed medication.

show abstract

Moxifloxacin-Associated Neutropenia in a Cirrhotic Elderly Woman with Lower Extremity Cellulitis

Abstract: We report the first case of moxifloxacin-associated neutropenia. Although such an adverse reaction is rare, clinicians should be aware of this potential complication of moxifloxacin therapy.

Cited by 14 publications

References 12 publications

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

Moxifloxacin-associated Neutropenia in a Patient Planned for Renal Transplantation

Moxifloxacin-induced neutropenia in 26-year-old man

A Case of Severe Neutropenia From Short-Term Exposure to Moxifloxacin

Contact Info

Product

Resources

About