Moxifloxacin-capped noble metal nanoparticles as potential urease inhibitors

Nisar, Muhammad; Khan, Shujaat Ali; Shah, Muhammad Raza; Khan, Ajmal; Farooq, Umar; Uddin, Ghias; Ahmad, Bashir

doi:10.1039/c5nj01571e

Cited by 18 publications

(8 citation statements)

References 43 publications

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“…5). It was revealed from FTIR results that amine and carboxylate moiety might be responsible for capping and stabilizing of Ag-Sp and Au-Sp NPs (Nisar et al, 2015). Fig.…”

Section: Ftir Characteristicsmentioning

confidence: 99%

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Synthesis, Characterization, and Antimicrobial Properties of Sparfloxacin-Mediated Noble Metal Nanoparticles

Nisar¹,

Khan²,

Gul³

et al. 2020

J Pure Appl Microbiol

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The aim of the current research finding was to synthesize, characterize and antibacterial evaluation of sparfloxacin-mediated noble metal nanoparticles. Noble metal [silver (Ag), and gold (Au)] nanoparticles (NPs), mediated with fluoroquinolone, an anti-bacterial drug [Sparfloxacin, (Sp)], was synthesized by a facile and convenient procedure. Formulated Ag-Sp NPs, and Au-Sp NPs exhibited stability against variation in pH, NaCl solution, temperature, and time. The structural topographies of Ag-Sp, and Au-Sp NPs were determined by fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy (UV-Vis), scanning electron microscopy (SEM) atomic force microscopy (AFM), and energy dispersive X-ray (EDX). UV-Vis revealed the formulation of NPs by showing typical surface Plasmon absorption maxima at 410 nm for Ag-Sp NPs and 555 nm for Au-Sp NPs. The AFM and SEM analysis ascertained stable mono dispersed Ag-Sp NPs and Au-Sp NPs in the size range of 40-50 nm, and 70-80 nm, respectively. Ag-Sp, and Au-Sp NPs exhibited antibacterial traits against Bacillus subtilis, Staphylococcus aureus, and Klebsiella pneumonia, showing a zone of inhibition (ZOI) ranging from 20±0.98 mm to 24±0.94 mm (Ag-Sp NPs), and 22±0.79 mm to 26±0.92 mm (Au-Sp NPs) at dose of 3 mg/mL.

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“…5). It was revealed from FTIR results that amine and carboxylate moiety might be responsible for capping and stabilizing of Ag-Sp and Au-Sp NPs (Nisar et al, 2015). Fig.…”

Section: Ftir Characteristicsmentioning

confidence: 99%

“…EDX illustrated (Fig. 4 a & b) the chemical nature of Ag-Sp and Au-Sp NPs showing signals at an energy of 3 KeV for silver, and 2.12 and 9.71 KeV for gold (Nisar et al, 2015).…”

Section: Afm Sem and Edx Analysesmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Properties of Sparfloxacin-Mediated Noble Metal Nanoparticles

Nisar¹,

Khan²,

Gul³

et al. 2020

J Pure Appl Microbiol

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“…Recently Moxifloxacin (compound 12 ) have been used for capping of silver and gold nanoparticles and appeared to be exceptional inhibitor of urease, more potent than antibiotic itself [59] .…”

Section: Quinolonesmentioning

confidence: 99%

Recent advances in design of new urease inhibitors: A review

Kafarski

Talma

2018

Journal of Advanced Research

193

111

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“…Recently the coupling of nanoparticles with drugs has been shown to produce a marked increase in the activity of the drugs, like antibiotics which when combined with nanoparticles display increased killing of bacteria [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28]. Metallic NPs reveal excellent antimicrobial activity against various pathogens such as fungi, bacteria and viruses and can play a key role in nanomedicine [29]. Urease belongs to the urea amido-hydrolase enzyme class.…”

Section: Introductionmentioning

confidence: 99%

Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay

et al. 2016

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The fluoroquinolone antibacterial drug ciprofloxacin (cip) has been used to cap metallic (silver and gold) nanoparticles by a robust one pot synthetic method under optimized conditions, using NaBH₄ as a mild reducing agent. Metallic nanoparticles (MNPs) showed constancy against variations in pH, table salt (NaCl) solution, and heat. Capping with metal ions (Ag/Au-cip) has significant implications for the solubility, pharmacokinetics and bioavailability of fluoroquinolone molecules. The metallic nanoparticles were characterized by several techniques such as ultraviolet visible spectroscopy (UV), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) methods. The nanoparticles synthesized using silver and gold were subjected to energy dispersive X-ray tests in order to show their metallic composition. The NH moiety of the piperazine group capped the Ag/Au surfaces, as revealed by spectroscopic studies. The synthesized nanoparticles were also assessed for urease inhibition potential. Fascinatingly, both Ag-cip and Au-cip NPs exhibited significant urease enzyme inhibitory potential, with IC50 = 1.181 ± 0.02 µg/mL and 52.55 ± 2.3 µg/mL, compared to ciprofloxacin (IC50 = 82.95 ± 1.62 µg/mL). MNPs also exhibited significant antibacterial activity against selected bacterial strains.

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Moxifloxacin-capped noble metal nanoparticles as potential urease inhibitors

Cited by 18 publications

References 43 publications

Synthesis, Characterization, and Antimicrobial Properties of Sparfloxacin-Mediated Noble Metal Nanoparticles

Synthesis, Characterization, and Antimicrobial Properties of Sparfloxacin-Mediated Noble Metal Nanoparticles

Recent advances in design of new urease inhibitors: A review

Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay

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