Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay

Nisar, Muhammad; Khan, Shujaat Ali; Qayum, Mughal; Khan, Ajmal; Farooq, Umar; Jaafar, Hawa Z. E.; Zia-Ul-Haq, Muhammad; Rashid, Ali

doi:10.3390/molecules21040411

Cited by 24 publications

(8 citation statements)

References 45 publications

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“…Hence, the inhibition of these enzymes is an important strategy to tackle infections, as has been well-documented in the literature. In one study, Ag NPs or Au NPs capped with ciprofloxacin, an antibiotic, demonstrated substantial improvement in their inhibition of bacterial urease [ 76 ]. In another, ZnO NPs of a small particle size showed strong antimicrobial activity against MRSA and could potentially inhibit the activity of β-galactosidase (GAL) [ 77 ].…”

Section: Antimicrobial Mechanism Of Nanoparticlesmentioning

confidence: 99%

Current approaches for the exploration of antimicrobial activities of nanoparticles

Rosli

Teow

Mahmoudi

2021

Science and Technology of Advanced Materials

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is currently pursuing a master's degree at Universiti Kebangsaan Malaysia (UKM). Her research focuses on the antimicrobial of nanoparticles for application in the industry. Dr. Teow Yeit Haan is a senior lecturer at UKM. Her expertise includes membrane synthesis and characterization, membrane application for water purification and wastewater treatment, membrane fouling, water disinfection technology, and adsorption. She had published more than 44 research articles, 22 conference proceedings, and 3 book chapters. Dr. Ebrahim Mahmoudi is working as a senior lecturer at UKM. He is researching separation and purification using polymeric membranes and membrane bioreactors. Current Approaches for the Exploration of Antimicrobial Activities of NanoparticlesInfectious diseases of bacterial and viral origins contribute to substantial mortality worldwide. Collaborative efforts have been underway between academia and the industry to develop technologies for a more effective treatment for such diseases. With their utility in various industrial applications, nanoparticles (NPs) offer promising potential as antimicrobial agents against bacterial and viral infections. NPs have been established to possess potent antimicrobial activities against various types of pathogens due to their unique characteristics and cell-damaging ability through several mechanisms. The recent accepted antimicrobial mechanisms possess by NPs include metal ion release, oxidative stress induction, and non-oxidative mechanisms. Another merit of NPs lies in the low likelihood of the development of microbial tolerance towards NPs,given the multiple simultaneous mechanisms of action against the pathogens targeting numerous gene mutations in those pathogens. Moreover, NPs provide a fascinating opportunity to curb microbial growth before infections: this outstanding feature has led to their utilization as active antimicrobial agents in different industrial applications, e.g. the coating of medical devices, incorporation in food packaging, promoting wound healing, and encapsulation with other potential materials for wastewater treatment. This review discusses the progress and achievements in the antimicrobial applications of NPs, factors contributing to their actions, mechanisms underlying their efficiency, and risks of their applications, including the antimicrobial action of metal nanoclusters (NCs).The review concludes with a discussion of the restrictions in present studies and future prospects of nanotechnology-based NPs development.

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Section: Antimicrobial Mechanism Of Nanoparticlesmentioning

confidence: 99%

Current approaches for the exploration of antimicrobial activities of nanoparticles

Rosli

Teow

Mahmoudi

2021

Science and Technology of Advanced Materials

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“…Fluoroquinolones inhibit DNA gyrase, which is an enzyme that plays a key role in metabolism and bacterial reproduction. There are two quinones generation, and the secondgeneration is the group which CIP is on [12,13]. Antibiotics from this generation have shown activity against Gram-negative and Grampositive bacteria and also against certain pathogens [14].…”

Section: Ciprofloxacinmentioning

confidence: 99%

Characterization and Microbiological Application of Ciprofloxacin Loaded in Natural Rubber Latex Membranes

Garms

Borges

Santos

et al. 2017

BJPR

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Natural rubber latex (NRL) from Hevea brasiliensis presents interesting characteristics in biomedical research due to its ability to stimulate angiogenesis, cellular adhesion and formation of extracellular matrix. A broad spectrum antibacterial agent used in skin infection is Ciprofloxacin hydrochloride (CIP). It is a fluoroquinolone employed to treat different bacterial infections caused by gram-positive and gram-negative microorganism. The aim of the present study is to promove Original Research Article

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“…Temperature is an important factor that affects the stability and properties of Ag-Sp NPs and Au-Sp NPs. Ag-Sp NPs were stable at broad range of temperatures (Nisar et al, 2016) (Fig. 6e).…”

Section: Stability Of Ag-sp and Au-sp Npsmentioning

confidence: 98%

Synthesis, Characterization, and Antimicrobial Properties of Sparfloxacin-Mediated Noble Metal Nanoparticles

Nisar¹,

Khan²,

Gul³

et al. 2020

J Pure Appl Microbiol

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The aim of the current research finding was to synthesize, characterize and antibacterial evaluation of sparfloxacin-mediated noble metal nanoparticles. Noble metal [silver (Ag), and gold (Au)] nanoparticles (NPs), mediated with fluoroquinolone, an anti-bacterial drug [Sparfloxacin, (Sp)], was synthesized by a facile and convenient procedure. Formulated Ag-Sp NPs, and Au-Sp NPs exhibited stability against variation in pH, NaCl solution, temperature, and time. The structural topographies of Ag-Sp, and Au-Sp NPs were determined by fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy (UV-Vis), scanning electron microscopy (SEM) atomic force microscopy (AFM), and energy dispersive X-ray (EDX). UV-Vis revealed the formulation of NPs by showing typical surface Plasmon absorption maxima at 410 nm for Ag-Sp NPs and 555 nm for Au-Sp NPs. The AFM and SEM analysis ascertained stable mono dispersed Ag-Sp NPs and Au-Sp NPs in the size range of 40-50 nm, and 70-80 nm, respectively. Ag-Sp, and Au-Sp NPs exhibited antibacterial traits against Bacillus subtilis, Staphylococcus aureus, and Klebsiella pneumonia, showing a zone of inhibition (ZOI) ranging from 20±0.98 mm to 24±0.94 mm (Ag-Sp NPs), and 22±0.79 mm to 26±0.92 mm (Au-Sp NPs) at dose of 3 mg/mL.

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Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay

Cited by 24 publications

References 45 publications

Current approaches for the exploration of antimicrobial activities of nanoparticles

Current approaches for the exploration of antimicrobial activities of nanoparticles

Characterization and Microbiological Application of Ciprofloxacin Loaded in Natural Rubber Latex Membranes

Synthesis, Characterization, and Antimicrobial Properties of Sparfloxacin-Mediated Noble Metal Nanoparticles

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