Moyamoya-Like Disease in Down’s Syndrome

Goldstein, Édward; Singer, Harvey S.

doi:10.1159/000120496

Cited by 16 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lesion in this case was shown in the usual portion. No other etiology of moyamoya‐like vessels, such as Down's syndrome, radiation therapy, atherosclerosis and inflammation, was present in this case 14–17 …”

Section: Discussionmentioning

confidence: 70%

“…No other etiology of moyamoya-like vessels, such as Down's syndrome, radiation therapy, atherosclerosis and inflammation, was present in this case. [14][15][16][17] Various morphologic findings of arteries in the proximal and peripheral portions, including mild lesions such as intimal thickening and severe lesions such as absence of medial smooth muscle cells with attenuation of arterial wall, were revealed. The abnormal behavior of the smooth muscle cells in the arterial walls might be related to these morphological changes of arterial walls and the hemorrhagic episodes are probably caused by rupture of arteries with attenuation, 2,7,8 or rupture of aneurysm in major arteries or in abnormal vascular networks.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease

Takekawa¹,

Umezawa

Ueno

et al. 2004

Neuropathology

View full text Add to dashboard Cite

Moyamoya disease is vaso-occlusive disease involving the arteries of the circle of Willis that is accompanied by a compensatory recruitment of a vascular network. The pathological and immunohistochemical findings of an autopsy case of hemorrhagic moyamoya disease in a 69-year-old woman are described in the present report. The autopsy findings of the brain revealed cerebral and intraventricular hemorrhage with edema. The left anterior cerebral artery, bilateral middle cerebral arteries and left posterior cerebral artery were marked narrowing, and the other arteries revealed mild narrowing. Microscopically, the arteries of the circle of Willis showed narrowed lumen, fibrocellular intimal thickening, marked tortuousness of internal elastic lamina and attenuation of media. The thickened intima was composed of smooth muscle cells. The vessels with dilated or irregular-shaped lumen suggested abnormal vascular networks demonstrated by angiography. In this case, no correlation between the abnormal vascular network and expression of VEGF or VEGF receptor was disclosed. It was hypothesized that abnormal vascular networks might be composed of collateral vessels in relation to various pathological changes of the arteries, such as occlusion and stenosis, and intracranial hemorrhage in patients with moyamoya disease might occur as a result of rupture of arteries including abnormal vascular networks.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease

Takekawa¹,

Umezawa

Ueno

et al. 2004

Neuropathology

View full text Add to dashboard Cite

show abstract

“…scribed [12][13][14] and is reported to be three times that of the general population 15 . An aberrant RSCA was detected prenatally in 16-39% of cases with Down syndrome 16 .…”

Section: Acknowledgementmentioning

confidence: 99%

Anomalous Origins of Bilateral Vertebral Arteries in a Child with down Syndrome and Moyamoya Disease

et al. 2012

View full text Add to dashboard Cite

Variations in vertebral artery origin and course are well-described in the literature. The origin of right vertebral artery from the right common carotid artery is an extremely rare variant. We describe a unique case of a child with Down syndrome with variant origins of bilateral vertebral artery, an aberrant right subclavian artery and concomitant Moyamoya disease of intracranial circulation. The presence of variations of the origin and course of craniocervical arteries might have profound implications in angiographic and surgical procedures and hence it is of great importance to be aware of such a possibility.

show abstract

“…Los niños con SD tienen un riesgo mayor de ACV isquémico, generalmente secundario a tromboem-bolismo cardíaco e infecciones bacterianas incluyendo meningitis y endocarditis 6 . El SMM es una causa poco común de ACV en pacientes con SD, pero su incidencia es 3 veces mayor que la incidencia esperada para la población general 7,8 .…”

Section: Discussionunclassified

Síndrome moyamoya en paciente con síndrome de Down y déficit de antitrombina III

Hernández

et al. 2009

Rev. méd. Chile

View full text Add to dashboard Cite

Moyamoya-Like Disease in Down’s Syndrome

Abstract: We present a case of a 6-year-old girl with Down’s syndrome who developed recurrent hemipareses. Cerebral angiography showed bilateral supraclinoid stenosis of internal carotid arteries and complexes of dilated collateral vessels, consistent with moyamoya disease.

Cited by 16 publications

References 6 publications

Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease

Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease

Anomalous Origins of Bilateral Vertebral Arteries in a Child with down Syndrome and Moyamoya Disease

Síndrome moyamoya en paciente con síndrome de Down y déficit de antitrombina III

Contact Info

Product

Resources

About