MR-based respiratory and cardiac motion correction for PET imaging

Küstner, Thomas; Schwartz, Martin; Martirosian, Petros; Gatidis, Sergios; Seith, Ferdinand; Gilliam, Christopher; Blu, Thierry; Fayad, Hadi; Visvikis, Dimitris; Schick, Fritz; Yang, Bin; Schmidt, Holger; Schwenzer, Nina F.

doi:10.1016/j.media.2017.08.002

Cited by 69 publications

(62 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our primary interest is in PET‐MR motion correction, where typically between 5 and 10 motion states are used for both respiratory and cardiac binning. See, for example …”

Section: Methodsmentioning

confidence: 99%

“…Another emerging application of cardiorespiratory motion tracking is for motion correction of positron emission tomography (PET) data during a simultaneous PET‐MR exam. Following the recent introduction of integrated PET‐MR, several works have demonstrated that motion information obtained from MR data can be used to compensate for patient motion during the PET image reconstruction …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiorespiratory motion‐tracking via self‐refocused rosette navigators

Rigie

Vahle

Zhao

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose: To develop a flexible method for tracking respiratory and cardiac motions throughout MR and PET-MR body examinations that requires no additional hardware and minimal sequence modification. Methods: The incorporation of a contrast-neutral rosette navigator module following the RF excitation allows for robust cardiorespiratory motion tracking with minimal impact on the host sequence. Spatial encoding gradients are applied to the FID signal and the desired motion signals are extracted with a blind source separation technique. This approach is validated with an anthropomorphic, PET-MR-compatible motion phantom as well as in 13 human subjects. Results: Both respiratory and cardiac motions were reliably extracted from the proposed rosette navigator in phantom and patient studies. In the phantom study, the MR-derived motion signals were additionally validated against the ground truth measurement of diaphragm displacement and left ventricle model triggering pulse. Conclusion: The proposed method yields accurate respiratory and cardiac motion-state tracking, requiring only a short (1.76 ms) additional navigator module, which is self-refocusing and imposes minimal constraints on sequence design.

show abstract

“…Our primary interest is in PET‐MR motion correction, where typically between 5 and 10 motion states are used for both respiratory and cardiac binning. See, for example …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory motion‐tracking via self‐refocused rosette navigators

Rigie

Vahle

Zhao

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…Previously proposed motion compensation techniques for cardiac PET‐MR imaging have focused on improving PET image quality using motion information estimated from MR . Several simulation, phantom, and patient studies have shown improved accuracy of PET uptake values in lesions and regions of interest and improved sharpness of anatomic structures such as the left ventricular myocardium .…”

Section: Introductionmentioning

confidence: 99%

“…Alternatively, a shorter MR acquisition can be performed at the beginning of the scan so that deformation fields are used to create a motion model that can be applied to longer PET acquisitions. This approach has been recently demonstrated in oncology patients, resulting in an increased uptake in liver, lung, and pancreatic lesions …”

Section: Introductionmentioning

confidence: 99%

Respiratory‐ and cardiac motion‐corrected simultaneous whole‐heart PET and dual phase coronary MR angiography

Muñoz

Neji

Kunze

et al. 2018

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose To develop a framework for efficient and simultaneous acquisition of motion‐compensated whole‐heart coronary MR angiography (CMRA) and left ventricular function by MR and myocardial integrity by PET on a 3T PET‐MR system. Methods An acquisition scheme based on a dual‐phase CMRA sequence acquired simultaneously with cardiac PET data has been developed. The framework is integrated with a motion‐corrected image reconstruction approach, so that non‐rigid respiratory and cardiac deformation fields estimated from MR images are used to correct both the CMRA (respiratory motion correction for each cardiac phase) and the PET data (respiratory and cardiac motion correction). The proposed approach was tested in a cohort of 8 healthy subjects and 6 patients with coronary artery disease. Left ventricular (LV) function estimated from motion‐corrected dual‐phase CMRA was compared to the gold standard estimated from a stack of 2D CINE images for the healthy subjects. Relative increase of signal in motion‐corrected PET images compared to uncorrected images was computed for standard 17‐segment polar maps for each patient. Results Motion‐corrected dual‐phase CMRA images allow for visualization of the coronary arteries in both systole and diastole for all healthy subjects and cardiac patients. LV functional indices from healthy subjects result in good agreement with the reference method, underestimating stroke volume by 3.07 ± 3.26 mL and ejection fraction by 0.30 ± 1.01%. Motion correction improved delineation of the myocardium in PET images, resulting in an increased 18 F‐FDG signal of up to 28% in basal segments of the myocardial wall compared to uncorrected images. Conclusion The proposed motion‐corrected dual‐phase CMRA and cardiac PET produces co‐registered good quality images in both modalities in a single efficient examination of ~13 min.

show abstract

“…9,10 Respiratory misregistration is only an aspect of this and partial response would follow from more systematic implementation of recent advances in respiratory and cardiac motion compensation algorithms during PET/MR acquisitions. 11,12 Yet, the most effective way to reduce misalignment lies in comfortable positioning of the patient and refraining from overextended acquisition protocols. This is appealing in PET/MRI to maximize the information collected and in part related to a pressure to provide more comprehensive results to justify the investment in PET/MRI clinical and research programs.…”

mentioning

confidence: 99%

Artifact-free quantitative cardiovascular PET/MR imaging: An impossible dream?

Zaidi

Nkoulou

2019

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

Building a winning team requires a bit of complementarity and convincing common goals to overcome the frustration of being tied together. In the journey of cardiac PET/MRI, this frustration has a name: less optimal attenuation correction (AC) as compared to its PET/CT counterpart where CT-based AC works reasonably well. AC has been a key component in the development of nuclear cardiology providing at the same time more reliable assessment of regions with relative tracer abnormalities and the ground for accurate quantification of tracer uptake.1 It is therefore no wonder that reproducing the same level of confidence in AC using MRI as achieved using CT has been a major drive in the research over PET/MRI in general and in cardiovascular imaging applications, in particular.MRI segmentation-based approaches have focused on deriving attenuation maps from basic MR sequences, such as T1-weighted or DIXON sequences; the latter consists of in-and opposed-phase images enabling segmentation in four tissue types (air, soft tissue, lung, and fat).2 Among the limitations of this approach, when using these sequences, is the inconsistent differentiation between air and bone densities. This is important when having in mind the position of the patient during thoracic PET/MRI with the arms laying aside the body to promote optimal positioning of the radiofrequency surface coils and the relatively small field of view of MR images (only 45-50 cm compared to 60-70 cm on contemporary PET/CT systems) that systematically brings about truncation artifacts. A number of strategies enabling to incorporate bone density have been proposed and potential solutions, such as ultrashort echo time and zero echo time sequences, have been proposed and refined and are finding their way to the clinic in the context of brain imaging. 3,4 In theory, incorporating an increased number of tissue types in the MRI-derived attenuation map would allow reducing quantification errors within the range of 5% compared to CT-derived attenuation maps as proposed by Keereman et al using five tissue types. 5The recent advances in detector technology embedded in the latest designs of PET/MRI systems have contributed to the revival of an old concept referred to as joint estimation of activity and attenuation maps from emission data. This method has capitalized on time-of-flight capability to refine the positioning information on PET lines of responses for improved signalto-noise ratio. 6 The attenuation maps could therefore be derived from the emission data using maximum likelihood reconstruction of activity and attenuation (MLAA) type of algorithms that are penalized using priors to reduce the cross-talk between activity and attenuation estimations. The scaling issue inherent in this approach has been recently dealt with using MLAA with a Gaussian mixture model approach.7 Noteworthily, this category of techniques is now routinely integrated by one of the manufacturers for the compensation of truncation artifacts.

show abstract

MR-based respiratory and cardiac motion correction for PET imaging

Cited by 69 publications

References 50 publications

Cardiorespiratory motion‐tracking via self‐refocused rosette navigators

Cardiorespiratory motion‐tracking via self‐refocused rosette navigators

Respiratory‐ and cardiac motion‐corrected simultaneous whole‐heart PET and dual phase coronary MR angiography

Artifact-free quantitative cardiovascular PET/MR imaging: An impossible dream?

Contact Info

Product

Resources

About