MR Cholangiopancreatography at 3.0 T

Patel, Hemant T; Shah, Ankur; Khandelwal, Shikha; Patel, Hiren F; Patel, Megha

doi:10.1148/rg.296095505

Cited by 27 publications

(10 citation statements)

References 11 publications

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“…3,4 To overcome the solubility issue, particle size reduction (micronized and nanocrystals) and lipid dispersions have been used in the commercialised formulations containing FEN. 1 With the increased use of the amorphous state of the drug in dispersion based formulations, [5][6][7][8] it is extremely important to fully understand the stability and crystallisation behaviour of amorphous FEN. Zhou and co-workers have conducted a systematic study of a range of low-molecular weight drugs including FEN 9 probing the relationship between physical stability and a range of thermodynamic properties.…”

Section: Fenobratementioning

confidence: 99%

Towards controlling the crystallisation behaviour of fenofibrate melt: triggers of crystallisation and polymorphic transformation

et al. 2018

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Section: Fenobratementioning

confidence: 99%

Towards controlling the crystallisation behaviour of fenofibrate melt: triggers of crystallisation and polymorphic transformation

et al. 2018

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“…In addition to the abovementioned indices, in this study, we also found that patients with acute pancreatitis combined with pancreatic carcinoma had dilatation of the pancreatic duct, limited interruption of the MPD, and a dilated CBD. Larena and Patel et al reported that the main pancreatic duct is rarely dilated in acute pancreatitis [24,25]. Our results suggest that when the pancreatic duct and/or CBD are dilated in cases of acute pancreatitis, an associated pancreatic carcinoma could exist.…”

Section: Discussionmentioning

confidence: 46%

Pancreatic Carcinoma with the First Symptom of Acute Pancreatitis: MRI Findings and Clinical Features

Y²,

Yf³

et al. 2014

Pancreat Disord Ther

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To study the MRI findings and clinical features of pancreatic carcinoma with the first symptom of acute pancreatitis. Materials and Methods:Twelve patients with pancreatic carcinoma and the first symptom of acute pancreatitis were included in this study. Pancreatic carcinoma with acute pancreatitis was confirmed by pathology. The MRI findings and clinical features of pancreatic carcinoma combined with acute pancreatitis were noted.Results: In the 12 patients with acute pancreatitis, the pancreas appeared edematous and non-necrotic on MRI. The pancreatic carcinomas were mainly located in the head of the pancreas (83.33%, 10/12). Most patients showed a mass on T1-weighted and T2-weighted images. A dilated pancreatic duct and/or Common Bile Duct (CBD) was observed on MRI of 75% (9/12) of the patients. The results of laboratory tests demonstrated increased CA19-9 in 8 of the patients (66.67%), elevation of both ALP and AST in 11 of the patients (91.67%), and normal ALP and AST levels in 1 patient.Conclusions: Acute pancreatitis may be an indicator of pancreatic carcinoma. A pancreatic mass and a dilated pancreatic duct and/or CBD observed by MRI can provide evidence of the associated pancreatic carcinoma. Increased levels of ALT, AST or ALP and CA19-9 may aid the diagnosis of pancreatic carcinoma in cases of acute pancreatitis.

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“…MRI has become an increasingly important imaging technique for investigating patients with hepatic and biliary disorders [23,24]. Although MRI examination is more expensive in comparison with computed tomography and ultrasound, this modality is widely used due to higher spatial resolution [25] and absence of ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the fact that MRI and MRS have become increasingly important imaging techniques for investigation of patients with liver and biliary disease [23,24], there are few papers describing application of in vivo MR-techniques for studying liver fluke infection [32–35] and no papers depicting the use of these methods for investigating O . felineus .…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging and spectroscopy for differential assessment of liver abnormalities induced by Opisthorchis felineus in an animal model

et al. 2017

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BackgroundEuropean liver fluke Opisthorchis felineus, causing opisthorchiasis disease, is widespread in Russia, Ukraine, Kazakhstan and sporadically detected in the EU countries. O. felineus infection leads to hepatobiliary pathological changes, cholangitis, fibrosis and, in severe cases, malignant transformation of bile ducts. Due to absence of specific symptoms, the infection is frequently neglected for a long period. The association of opisthorchiasis with almost incurable bile duct cancer and rising international migration of people that increases the risk of the parasitic etiology of liver fibrosis in non-endemic regions determine high demand for development of approaches to opisthorchiasis detection.Methodology/Principal findingsIn vivo magnetic resonance imaging and spectroscopy (MRI and MRS) were applied for differential assessment of hepatic abnormalities induced by O. felineus in an experimental animal model. Correlations of the MR-findings with the histological data as well as the data of the biochemical analysis of liver tissue were found. MRI provides valuable information about the severity of liver impairments induced by opisthorchiasis. An MR image of O. felineus infected liver has a characteristic pattern that differs from that of closely related liver fluke infections. 1H and 31P MRS in combination with biochemical analysis data showed that O. felineus infection disturbed hepatic metabolism of the host, which was accompanied by cholesterol accumulation in the liver.ConclusionsA non-invasive approach based on the magnetic resonance technique is very advantageous and may be successfully used not only for diagnosing and evaluating liver damage induced by O. felineus, but also for investigating metabolic changes arising in the infected organ. Since damages induced by the liver fluke take place in different liver lobes, MRI has the potential to overcome liver biopsy sampling variability that limits predictive validity of biopsy analysis for staging liver fluke-induced fibrosis.

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MR Cholangiopancreatography at 3.0 T

Cited by 27 publications

References 11 publications

Towards controlling the crystallisation behaviour of fenofibrate melt: triggers of crystallisation and polymorphic transformation

Towards controlling the crystallisation behaviour of fenofibrate melt: triggers of crystallisation and polymorphic transformation

Pancreatic Carcinoma with the First Symptom of Acute Pancreatitis: MRI Findings and Clinical Features

Magnetic resonance imaging and spectroscopy for differential assessment of liver abnormalities induced by Opisthorchis felineus in an animal model

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